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Bovine Spongiform Encephalopathy Distribution and Update on Some Transmission and Decontamination Studies

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Bovine Spongiform Encephalopathy

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

A report (1) of a scrapie-like disease in a captive nyala (Tragelaphus angasi) in England heralded the start of the epidemic of bovine spongiform encephalopathy (BSE). In November 1986 the first cases of BSE were confirmed by histologic examination of the brain from affected cattle from two areas of southern England (2). Subsequently it was reported that clinical cases of BSE, unrecognized at the time, had probably occurred as early as April 1985 and that the origin of infection, in the first 190 cases or so, was feed in the form of ruminant-derived meat and bone meal (MBM) (3). Nothing has occurred since to alter this view (4).

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References

  1. Anon. Scrapie-like disease in a captive nyala. Animal Health 1986 report of the chief veterinary officer. London: HMSO, 1987.

    Google Scholar 

  2. Wells GAH, Scott AC, Johnson CT, Gunning RF, Hancock RD, Jeffrey M, et al. A novel progressive spongiform encephlaopathy in cattle. Vet Rec 1987;121:419–420.

    Article  PubMed  CAS  Google Scholar 

  3. Wilesmith JW, Wells GAH, Cranwell MP, Ryan JBM. Bovine spongiform encephalopathy: epidemiological studies. Vet Rec 1988;123:638–644.

    PubMed  CAS  Google Scholar 

  4. Wilesmith JW, Ryan JBM, Hueston WD. Bovine spongiform encephalopathy: case-control studies of calf feeding practices and meat and bone meal inclusion in proprietary concentrates. Res Vet Sci 1992;52:325–331.

    Article  PubMed  CAS  Google Scholar 

  5. Wilesmith JW, Ryan JBM, Atkinson MJ. Bovine spongiform encephalopathy: epidemiological studies on the origin. Vet Rec 1991;128:199–203.

    Article  PubMed  CAS  Google Scholar 

  6. Woodgate SL. Rendering systems and BSE agent deactivation. Livestock Prod Sci 1994;38:47–50.

    Article  Google Scholar 

  7. Wrathall AE, Brown KFD. Embryo transfer, semen, scrapie and BSE. In: Bradley R, Savey M, Marchant B, eds. Sub-acute spongiform encephalopathies. Proceedings of a seminar held in Brussels, November 12–14, 1990. Dordrecht: Kluwer Academic, 1991:243–253.

    Google Scholar 

  8. Commission Decision—94/381/EC. Concerning certain protection measures with regard to bovine spongiform encephalopathy and the feeding of mammalian derived protein. Official Journal of the European Communities, No. L 172/23, July 7, 1994, Brussels.

    Google Scholar 

  9. Wood JLN, Lund LJ, Done SH. The natural occurrence of scrapie in moufflon. Vet Rec 1992;130:25–27.

    Article  PubMed  CAS  Google Scholar 

  10. Kirkwood JW, Cunningham AA. Epidemiological observations on spongiform encephalopathies in captive wild animals in the British Isles. Vet Rec 1994; 135:296–303.

    Article  PubMed  CAS  Google Scholar 

  11. Kirkwood JW, Wells GAH, Cunningham AA, Jackson SI, Scott AC, Dawson M, et al. Scrapie-like encephalopathy in a greater kudu (Tragelaphus strepsiceros) which had not been fed ruminant-derived protein. Vet Rec 1992;130:365–367.

    Article  PubMed  CAS  Google Scholar 

  12. Wyatt JM, Pearson GR, Smerdon TN, Gruffydd-Jones TJ. Wells GAH. Spongiform encephalopathy in a cat. Vet Rec 1990;126:513.

    Google Scholar 

  13. Willoughby K, Kelly DF, Lyon DG, Wells GAH. Spongiform encephalopathy in a captive puma (Felis concolor). Vet Rec 1992;131:431–434.

    Article  PubMed  CAS  Google Scholar 

  14. Office International des Epizooties. Spongiform encephalopathy in an imported cheetah in Australia. Dis Inform 1992;5:52.

    Google Scholar 

  15. Peet RJ, Curran JM. Spongiform encephalopathy in an imported cheetah (Acinonyx jubatus). Aust Vet J 1992;69:171.

    Article  PubMed  CAS  Google Scholar 

  16. Kelly DF, Pearson H, Wright AI, Greenham LW. Morbidity in captive white tigers. In: The proceedings of a symposium on comparative pathology of zoo animals. Washington, DC: National Zoological Park, October 1978.

    Google Scholar 

  17. Schoon HA, Brunckhorst D, Pohlenz J. A contribution to the neuropathology of the red-necked ostrich (Struthio camelus)—spongiform encephalopathy [in German]. Verh Erkrank Zootiere 1991;33:309–314.

    Google Scholar 

  18. Schoon HA, Brunckhorst D, Pohlenz J. Spongiform encephalopathy in an ostrich (Struthio camelus). A case report [in German]. Tierarztl Prax 1991; 19:263–265.

    PubMed  CAS  Google Scholar 

  19. Fraser H, McConnell I, Wells GAH, Dawson M. Transmission of bovine spongiform encephalopathy to mice. Vet Rec 1988;123:472.

    Article  PubMed  CAS  Google Scholar 

  20. Dawson M, Wells GAH, Parker BNJ. Preliminary evidence of the experimental transmissibility of bovine spongiform encephalopathy to cattle. Vet Rec 1990;126:112–113.

    PubMed  CAS  Google Scholar 

  21. Dawson M, Wells GAH, Parker BNJ, Scott AC. Primary parenteral transmission of bovine spongiform encephalopathy to the pig. Vet Rec 1990;127:338.

    PubMed  CAS  Google Scholar 

  22. Foster JD, Hope J, Fraser H. Transmission of bovine spongiform encephalopathy to sheep and goats. Vet Rec 1993;133:339–341.

    Article  PubMed  CAS  Google Scholar 

  23. Baker HF, Ridley RM, Wells GAH. Experimental transmission of BSE and scrapie to the common marmoset. Vet Rec 1993;132:403–406.

    Article  PubMed  CAS  Google Scholar 

  24. Robinson MM, Hadlow WJ, Huff TP, Wells GAH, Dawson M, Marsh RF, et al. Experimental infection of mink with bovine spongiform encephalopathy. J Gen Virol 1994;75:2151–2155.

    Article  PubMed  Google Scholar 

  25. Barlow RM, Middleton DJ. Dietary transmission of bovine spongiform encephalopathy to mice. Vet Rec 1990;126:111–112.

    PubMed  CAS  Google Scholar 

  26. Barlow RM, Middleton DJ. Is BSE simply scrapie in cattle? Vet Rec 1990;126:295.

    PubMed  CAS  Google Scholar 

  27. Middleton DJ, Barlow RM. Failure to transmit bovine spongiform encephalopathy to mice by feeding them with extraneural tissues of affected cattle. Vet Rec 1993;132:545–547.

    Article  PubMed  CAS  Google Scholar 

  28. Bruce M, Chree A, McConnell I, Foster J, Pearson G, Fraser H. Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier. Philos Trans R Soc Lond [Biol] 1994;343:405–411.

    Article  CAS  Google Scholar 

  29. Kimberlin RH, Walker CA, Fraser H. The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. J Gen Virol 1989;70:2017–2025.

    Article  PubMed  Google Scholar 

  30. Pattison IH, Hoare MN, Jebbett JN, Watson WA. Further observations on the production of scrapie in sheep by oral dosing with foetal membranes from scrapie-affected sheep. Br Vet J 1974;130:lxv–lxvii.

    PubMed  CAS  Google Scholar 

  31. Fraser H, Foster JD. Transmission to mice, sheep and goats and bioassay of bovine tissues. In: Bradley R, Marchant B, eds. Transmissible spongiform encephalopathies. Proceedings of a consultation on BSE with the Scientific Veterinary Committee of the Commision of the European Communities held in Brussels, September 14–15, 1993. Brussels: CEC, 1994:145–159.

    Google Scholar 

  32. Report of the Working Party on Bovine Spongiform Encephalopathy. Department of Health, Ministry of Agriculture, Fisheries and Food. February 1989, London (The Southwood Report).

    Google Scholar 

  33. Wilesmith JW. The epidemiology of bovine spongiform encephalopathy. Semin Virol 1991;2:239–245.

    Google Scholar 

  34. Bradley R, Wilesmith JW. Epidemiology and control of bovine spongiform encephalopathy (BSE). Br Med Bull 1993;49:932–959.

    PubMed  CAS  Google Scholar 

  35. Foster JD, McKelvey WAC, Mylne MJA, Williams A, Hunter N, Hope J, et al. Studies on maternal transmission of scrapie in sheep by embryo transfer. Vet Rec 1992;130:341–343.

    Article  PubMed  CAS  Google Scholar 

  36. Bradley R. Embryo transfer and its potential role in control of scrapie and bovine spongiform encephalopathy (BSE). Livestock Prod Sci 1994;38:51–59.

    Article  Google Scholar 

  37. Hadlow WJ, Kennedy RC, Race RE. Natural infection of Suffolk sheep with scrapie virus. J Infect Dis 1982;146:657–664.

    Article  PubMed  CAS  Google Scholar 

  38. Hope J, Reekie LJD, Hunter N, Multhaup G, Beyreuther K, White H, et al. Fibrils from brains of cows with new cattle disease contain scrapie-associated protein. Nature 1988;336:390–392.

    Article  PubMed  CAS  Google Scholar 

  39. Scott AC, Wells GAH, Stack MJ, White H, Dawson M. Bovine spongiform encephalopathy: detection and quantitation of fibrils, fibril protein (PrP) and vacuolation in brain. Vet Micro 1990;23:295–304.

    Article  CAS  Google Scholar 

  40. Scott AC, Wells GAH, Chaplin MJ, Dawson M. Bovine spongiform encephalopathy: detection of fibrils in the central nervous system is not affected by autolysis. Res Vet Sci 1992;52:332–336.

    Article  PubMed  CAS  Google Scholar 

  41. Taylor DM, Fraser H, McConnell I, Brown DA, Brown KL, Lamza KA, et al. Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie. Arch Virol 1994;139:313–326.

    Article  PubMed  CAS  Google Scholar 

  42. Taylor DM. Deactivation of BSE and scrapie agents: rendering and other UK studies. In: Bradley R, Marchant B, eds. Transmissible spongiform encephalopathies. Proceedings of a consultation on BSE with the Scientific Veterinary Committee of the Commision of the European Communities held in Brussels, September 14–15, 1993. Brussels: CEC, 1994:205–223.

    Google Scholar 

  43. Commission Decision—94/382/EC. On the approval of alternative heat treatment systems for processing animal waste of ruminant origin, with a view to the inactivation of spongiform encephalopathy agents. Official Journal of the European Communities, No. L 172/25, 7 July 1994, Brussels.

    Google Scholar 

  44. Taylor DM, Woodgate SL, Atkinson MJ. Inactivation of the bovine spongiform encephalopathy agent by rendering procedures. Vet Rec 1995;137:605–610.

    PubMed  CAS  Google Scholar 

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Authors
  1. Ray Bradley
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Editors and Affiliations

  1. Laboratory of Central Nervous System Studies Basic Neurosciences Program Division of Intramural Research, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD, 20892-4122, USA

    Clarence J. Gibbs Jr. Ph.D.

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Bradley, R. (1996). Bovine Spongiform Encephalopathy Distribution and Update on Some Transmission and Decontamination Studies. In: Gibbs, C.J. (eds) Bovine Spongiform Encephalopathy. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2406-8_2

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  • DOI: https://doi.org/10.1007/978-1-4612-2406-8_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7527-5

  • Online ISBN: 978-1-4612-2406-8

  • eBook Packages: Springer Book Archive

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