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Paget’s Disease of the Nipple-Areola Complex

  • Chapter
Breast Cancer

Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA))

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Abstract

The characteristic erythema and scaly eczematous change of the nipple seen with Paget’s disease of the breast were first described by Velpeau in 1856.1 It was not until 1874, however, that Sir James Paget described the relation between these characteristic nipple-areola changes and the association with underlying infiltrating or intraductal carcinoma of the breast. In the series reported by Paget, all patients ultimately developed underlying breast carcinoma within 1 year of the nipple changes.2

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References

  1. Velpeau S. Treatise on Diseases of the Breast and Mammary Region. London: Sydenham Society, 1856.

    Google Scholar 

  2. Paget J. On the disease of the mammary areola preceding cancer of the mammary gland. St. Bartholomew Hosp Rep 1874;10:87–89.

    Google Scholar 

  3. Ascensao AC, Marques MSJ, Capitao-Mor M. Paget’s disease of the nipple: clinical and pathological review of 109 female patients. Dermatologica 1985;170:170–179.

    Article  Google Scholar 

  4. Ashikari R, Park K, Huvos AG, et al. Paget’s disease of the breast. Cancer 1970;26:680–685.

    Article  PubMed  CAS  Google Scholar 

  5. Chaudary MA, Millis RR, Lane EB, et al. Paget’s disease of the nipple: a ten year review including clinical, pathological, and immunohistochemical findings. Breast Cancer Res Treat 1986;8:139–146.

    Article  PubMed  CAS  Google Scholar 

  6. Nance FC, DeLoach DH, Welsh RA, et al. Paget’s disease of the breast. Ann Surg 1970;171:864–874.

    Article  PubMed  CAS  Google Scholar 

  7. Desai DC, Brennan EJ, Carp NZ. Paget’s disease of the male breast. Am Surg 1996;62:1068–1072.

    PubMed  CAS  Google Scholar 

  8. Osther PJ, Balslev E, Blichert-Toft M. Paget’s disease of the nipple: a continuing enigma. Acta Chir Scand 1990;156:343–352.

    PubMed  CAS  Google Scholar 

  9. Masters RK, Robertson JFR, Blarney RW. Healed Paget’s disease of the nipple. Lancet 1993;341:253.

    Article  PubMed  CAS  Google Scholar 

  10. Stomper PC, Penetrante RB, Carson WE. Sensitivity of mammography on patients with Paget’s disease of the nipple. Breast Dis 1995;8:173–178.

    Google Scholar 

  11. Sawyer RH, Asbury DL. Mammographic appearances in Paget’s disease of the breast. Clin Radiol 1994;49:185–188.

    Article  PubMed  CAS  Google Scholar 

  12. Ikeda DM, Helvie MA, Frank TS, et al. Paget’s disease of the nipple: radiologie-pathologie correlation. Radiology 1993;189:89–94.

    PubMed  CAS  Google Scholar 

  13. Samarasinghe D, Frost F, Sterrett G, et al. Cytological diagnosis of Paget’s disease of the nipple by scrape smears: a report of five cases. Diagn Cytopathol 1993;9:2915.

    Google Scholar 

  14. Hitchcock A, Topham S, Bell J, et al. Routine diagnosis of mammary Paget’s disease: a modern approach. Am J Surg Pathol 1992;16:58–61.

    Article  PubMed  CAS  Google Scholar 

  15. Ramachandra S, Gillett CE, Millis RR. A comparative immunohistochemical study of mammary and extra-mammary Paget’s disease and superficial spreading melanoma, with particular emphasis on melanocytic markers. Virchows Arch 1996;429:371–376.

    Article  PubMed  CAS  Google Scholar 

  16. Vielh P, Validire P, Kheirallah S, et al. Paget’s disease of the nipple without clinically and radiologically detectable breast tumor: histochemical and immunohistochemical study of 44 cases. Pathol Res Pract 1993;189:150–155.

    PubMed  CAS  Google Scholar 

  17. Muir R. The pathogenesis of Paget’s disease of the nipple and associated lesions. Br J Surg 1935;22:728–737.

    Article  Google Scholar 

  18. Muir R. Further observations on Paget’s disease on the nipple and associated lesions. J Pathol 1939;49:299–312.

    Article  Google Scholar 

  19. Sagami S. Electron microscopic studies in Paget’s disease. Med J Osaka Univ 1963;14:173.

    PubMed  CAS  Google Scholar 

  20. Sagebiel RW. Ultrastructural observations on epidermal cells in Paget’s disease of the breast. Am J Pathol 1969;57:49–64.

    PubMed  CAS  Google Scholar 

  21. DePotter CR, Eeckhout I, Schelfhout A-M, et al. Keratinocyte-induced Chemotaxis in the pathogenesis of Paget’s disease of the breast. Histopathology 1994;24:349–356.

    Article  CAS  Google Scholar 

  22. Lagios MD, Westdahl PR, Rose MR, et al. Paget’s disease of the nipple: alternative management in cases without or with minimal extent of underlying breast carcinoma. Cancer 1984;54:545–551.

    Article  PubMed  CAS  Google Scholar 

  23. Banerjee SN, Estabrook A, Schnabel FR. Surgical treatment of Paget’s disease. In: Silverstein MJ (ed) Ductal Carcinoma In Situ of the Breast. Baltimore: Williams & Wilkins, 1997;551–554.

    Google Scholar 

  24. Fourquet A, Campana F, Vielh P, et al. Paget’s disease of the nipple without detectable breast tumor: conservative management with radiation therapy. Int J Radiat Oncol Biol Phys 1987;13:1463–1465.

    Article  PubMed  CAS  Google Scholar 

  25. Bulens P, Vanuytsel L, Rijnders A, et al. Breast conserving treatment of Paget’s disease. Radiother Oncol 1990;17:305–309.

    Article  PubMed  CAS  Google Scholar 

  26. Stockdale AD, Brierley JD, White WF, et al. Radiotherapy for Paget’s disease of the nipple: a conservative alternative. Lancet 1989;2:664–666.

    Article  PubMed  CAS  Google Scholar 

  27. El-Sharkawi A, Waters JS. The place for conservative treatment in the management of Paget’s disease of the nipple. Eur J Surg Oncol 1992;18:301–303.

    PubMed  CAS  Google Scholar 

  28. Paone JF, Baker RR. Pathogenesis and treatment of Paget’s disease of the breast. Cancer 1981;48:825–829.

    Article  PubMed  CAS  Google Scholar 

  29. Dixon AR, Galea MH, Ellis IO, et al. Paget’s disease of the nipple. Br J Surg 1991;78:722–723.

    Article  PubMed  CAS  Google Scholar 

  30. EORTC 10873. Phase II study. Breast conserving therapy in Paget’s disease of the nipple. (Trial ongoing).

    Google Scholar 

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Authors
  1. Kelly K. Hunt
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  2. Merrick I. Ross
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Editors and Affiliations

  1. Surgical Breast Section, Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Box 106, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    S. Eva Singletary M.D., FACS (Professor of Surgery, Chief) (Professor of Surgery, Chief)

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© 1999 Springer-Verlag New York, Inc.

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Hunt, K.K., Ross, M.I. (1999). Paget’s Disease of the Nipple-Areola Complex. In: Singletary, S.E. (eds) Breast Cancer. M.D. Anderson Solid Tumor Oncology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2146-3_20

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  • DOI: https://doi.org/10.1007/978-1-4612-2146-3_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7432-2

  • Online ISBN: 978-1-4612-2146-3

  • eBook Packages: Springer Book Archive

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