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The Growth Hormone Insulin-Like Growth Factor-I Axis

  • Chapter
Growth Factors and Wound Healing

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

Somatotropin or growth hormone (GH) is the most abundant hormone in the human pituitary. GH is a peptide synthesized and secreted by the anterior pituitary, and is an important regulator of growth and differentiated function. Human GH differs from that of other species, including primates, making it unique among pituitary hormones; whereas adrenocorticotropic hormone (ACTH), prolactin, and thyroid stimulating hormone extracted from other species have bioactivity in humans, GH from other species has no effect in humans (1). As opposed to all other anterior pituitary hormones, which act only on specific target organs, GH has effects on multiple target tissues throughout the body. Interestingly, GH exerts its effects directly on some tissues, and on other tissues the insulin-like growth factors (IGFs, particularly IGF-I) mediate the growth-promoting and anabolic effects of GH.

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Authors
  1. Arvind Y. Krishna
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  2. Lawrence S. Phillips
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Editor information

Editors and Affiliations

  1. Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Thomas R. Ziegler M.D.

  2. Department of Preclinical Development, PRIZM Pharmaceuticals, San Diego, CA, 92121, USA

    Glenn F. Pierce Ph.D., M.D.

  3. Shriners Burns Institute, The University of Texas Medical Branch, Galveston, TX, 77550, USA

    David N. Herndon M.D.

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© 1997 Springer Science+Business Media New York

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Krishna, A.Y., Phillips, L.S. (1997). The Growth Hormone Insulin-Like Growth Factor-I Axis. In: Ziegler, T.R., Pierce, G.F., Herndon, D.N. (eds) Growth Factors and Wound Healing. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1876-0_5

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