Abstract
Plastic induration of the penis, referred to as Peyronie’s disease, was described in 1743 by the French physician François de la Peyronie1 when he reported on three patients with scar tissue that resulted in an upward curvature of the penis during erection. This fibrous inelastic scar involving the tunica albuginea of the corpora cavernosa is the distinguishing characteristic of this disease. The typical symptoms include a palpable scar (frequently referred to as a Peyronie’s plaque), on the shaft of the penis, complaints of pain and abnormal curvature during erection, and difficulty with coitus because of the deformity or diminished rigidity or both. This condition often leads to unsatisfactory sexual performance and profound psychological trauma.2
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
de La Peyronie F. Sur quelques obstacles qui s’opposent a l’éjaculation naturelle de la 19. semence. Mem de l’Acad Roy de Chir 1743; 1:425–434.
Gelbard MK, Dorey F, James K. The natural 20. history of Peyronie’s disease. J Urol 1990; 144:1376–1379. 21.
Lindsay MB, Schain DM, Grambsch P, et al. The incidence of Peyronie’s disease in Rochester, Minnesota, 1950 through 1984. J Urol 1991; 146:1007–1009.
Vorstman B, Lockhart J. Peyronie’s disease. 22. Probl Urol 1987; 1:507.
Hinman F. Etiologic factors in Peyronie’s dis- 23. ease. Urol Int 1980; 35:407–413.
Mira JG. Is it worthwhile to treat Peyronie’s disease. Urology 1980; 16:1–6. 24.
Williams JL, Thomas GG. The natural history of Peyronie’s disease. J Urol 1970; 103:75–76.
Smith BH. Peyronie’s disease. Am J Clin Pathol 25. 1966; 45:670–678.
Somers KD, Sismour EN, Wright GL, et al. Isolation and characterization of collagen in 26. Peyronie’s disease. J Urol 1989; 141:629–631.
Helvie WW, Ochsner SF. Radiation therapy in Peyronie’s disease. South Med J 1972; 65:1192–1196.
Blandy JP. Penis and scrotum. In: John Blandy, 27. ed. Urology, vol. 2. Oxford: Blackwell; 1976: 1049–1095.
Roddy MT, Goldstein I. Peyronie’s disease. Part I. AUA Update Series 1991; 10.
Devine CJ, Sommers KD, Wright GL Jr, et al. A working model for the genesis of Peyronie’s dis- 29. ease derived from its pathobiology. J Urol 1988; 139(part 2):286A, abstract 495.
Iacono F, Barva S, De Rosa G, et al. Microstructural disorders of tunica albuginea in patients affected by Peyronie’s disease with or without erection dysfunction. J Urol 1993; 150:1806–1809.
Akkus E, Carrier S, Rahman J, et al. Structural alterations in the tunica albuginea: relevance to Peyronie’s disease and impotence. Int J Impotence 1994; Res 6(suppl 1):D206.
Levine LA, Merrick PF, Lee RC. Intralesional verapamil injection for the treatment of Peyronie’s disease. J Urol 1994; 151:1522–1524.
Gelbard M. Peyronie’s disease. In: Hashmat AI, Das S, eds. The Penis. Malvern: Lea & Febiger; 1993:244–625.
Furlow WL, Swenson HE, Lee RE. Peyronie’s disease: a study of its natural history and treatment with orthovoltage radiotherapy. J Urol 1975; 114:69–71.
Williams G, Green NA. The nonsurgical treatment of Peyronie’s disease. Br J Urol 1980; 52:392–395.
Mazo VE. Nov metod za lschenie na bolestta na Peironi. Khirurgiia (Sofia) 1989; 42(4):30–31.
Bellorofonte C, Ruoppolo M, Tura M, et al. Possibilita di impiego del litotritore piezoelettrico nel trattamento delle fibrosi cavernose gravi. Arch Ital Urol Netrol Androl 1989; 61: 417–422.
Frank IN, Scott WW. The ultrasonic treatment of Peyronie’s diesease. J Urol 1971; 106:83–87.
Scott WW, Scardino PL. A new concept in the treatment of Peyronie’s disease. South Med J 1948; 41:173–177.
Zarafonetis CJD, Horrax TM. Treatment of Peyronie’s disease with Potaba. J Urol 1959; 81:770–772.
Ralph DJ, Brooks MD, Battazzo GF, et al. The treatment of Peyronie’s disease with tamoxifen. Br J Urol 1992; 70:648–651.
Colletta AA, Wakefield LM, Howell FV, et al. Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. Br J Cancer 1990; 62:405–409.
Wahl SM, McCartney-Francis N, Mergenhagen SE. Inflammatory and immunomodulatory roles of TGF-(3. Immunol Today 1989; 10:258–261.
Oosterlinck W, Renders G. Treatment of Peyronie’s disease with procarbazine Br J Urol 1975; 47:219–220.
Morgan RI, Pryor JP. Procarbazine (Natulan) in the treatment of Peyronie’s disease. Br J Urol 1978; 50:111–113.
Akkus E, Carrier S, Rehman J, et al. Is colchicine effective in Peyronie’s disease? A pilot study. Urology 1994; 44:291–295.
Kershenobich D, Vargas F, Garsia-Tsao G, et al. Colchicine in the treatment of cirrhosis of the liver. N Engl J Med 1988; 318:1709–1713.
Diegelmann RF, Peterkofsky B. Inhibition of collagen secretion from bone and cultured fibroblasts by microtubular disruptive drugs. Proc Natl Acad Sci USA 1972; 69:892–896.
Ehrlich HP, Bornstein P. Microtubules in transcellular movement of procollagen. Nature 1972; 238:257–260.
Harris ED Jr, Krane SM. Effects of colchicine on collagenase in culture of rheumatoid synovium. Arthritis Rheum 1971; 14:669–684.
Tearsley GH. Peyronie’s disease: the new approach. J Urol 1954; 105:523.
Bodner H, Howard AH, Kaplan JH. Peyronie’s disease: cortisone-hyaluronidase-hydrocortisone therapy. J Urol 1954; 134:400.
Winter CC, Khanna R. Peyronie’s disease: results with dermo-jet injection of dexamethasone. J Urol 1954; 72:400–403.
Pentland AP, Anderson TF. Plantar fibromatosis responds to intralesional steroids. J Am Acad Dermatol 1985; 2:212–214.
Uitto J, Santa-Cruz DJ, Eisen AZ, et al. Chromomycosis. Successful treatment with 5fluorocytosine. J Cutan Pathol 1979; 6:77–84.
Morales A, Bruce AW. The treatment of Peyronie’s disease with parathyroid hormone. J Urol 1975; 114:901–902.
Walker DG, Lapiere CM, Gross J. A collagenolytic factor in rat bone promoted by parathyroid extract. Biochem Biophys Res Commun 1964; 15:397.
Gelbard MK, Walsh R, Kaufman JJ. Collagenase for Peyronie’s disease experimental studies. Urol Res 1982; 10:135–140.
Gelbard MK, James N, Riach P, et al. Collagenase versus placebo in the treatment of Peyronie’s disease: a double blind study. J Urol 1993; 149:397–402.
Kelâmi A. Classification of congenital and acquired penile deviation. Urol Int 1983; 38:229–233.
Gustafson H, Johansson B, Edsmyr F. Peyronie’s disease: experience of local treatment with Orgotein. Eur Urol 1981; 7:346–348.
Bartsch C, Menander-Huber KB, Huber W, et al. Orgotein, a new drug for the treatment of Peyronie’s disease. Eur J Rheumatol Inflamm 1981; 4:250–259.
Verges J, Chateau A. Nouveau traitement dela maladie La Peyronie: la superoxyde desmutase par ionisations. Comparaison avec une serie ancienne classique. Ann Urol (Paris) 1988; 22:143–144.
Primus G. Orgotein in the treatment of plastic induration of the penis (Peyronie’s) disease. Int Urol Nephrol 1993; 25:169–172.
Kelly RB. Pathways of protein secretion in eukariots. Science 1985; 230:25–32.
Aggeler J, Frisch SM, Werb Z. Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts. J Cell Biol 1984; 98:1662–1671.
Gelbard M, Lindler A, Chvapil M, et al. Topical beta-aminopropionitrile in the treatment of Peyronie’s disease. J Urol 1983; 129:746–748.
Duncan MR, Berman B, Nseyo UO. Regulation of the proliferation and biosynthetic activities of cultured human Peyronie’s disease fibroblasts by interferons-alpha, -beta and -gamma. Scand J Urol Nephrol 1991; 25:89–94.
Berman R, Duncan MR. Short-term keloid treatment in vivo with human interferon alpha2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan and collagenase production in vitro. J Am Acad Dermatol 1989; 21:694–702.
Duncan MR, Berman B. Persistence of a reduced-collagen producing phenotype in cultured scleroderma fibroblasts after short-term exposure to interferons. J Clin Invest 1987; 79:1318–1324.
Kahari V-M, Heino J, Vuorio T, et al. Interferon-alpha and interferon-gamma reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture. Biochem Biophys Acta 1988; 968:45–50.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Levine, L.A., Elterman, L. (1997). Peyronie’s Disease and Its Medical Management. In: Hellstrom, W.J.G. (eds) Male Infertility and Sexual Dysfunction. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1848-7_35
Download citation
DOI: https://doi.org/10.1007/978-1-4612-1848-7_35
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7310-3
Online ISBN: 978-1-4612-1848-7
eBook Packages: Springer Book Archive