Skip to main content
SpringerLink
Log in

Hepatic Arterial Infusion Chemotherapy for Colorectal Cancer Metastasis to the Liver

  • Chapter
Liver Cancer

Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA))

Abstract

The liver is the most common site of distant organ metastasis in patients with colorectal carcinoma. Of the 160,000 patients who develop colorectal carcinoma each year in the United States, half develop a recurrence at some point in their lifetimes, with the liver being the most common site (70%). 1 Although we have developed a better understanding of the molecular determinants that lead to colorectal cancer progression and metastasis, little progress has been made in therapy for metastatic disease. Fewer than 10% of patients who develop liver metastasis can undergo potentially curative resection.2 Despite advances in surgical technology and imaging techniques, at least half of the patients who undergo liver resection for metastatic colorectal cancer suffer a recurrence. Systemic chemotherapy for liver metastasis from colorectal cancer results in only one-third of patients obtaining a partial response, with complete responses being anecdotal.3,4

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pestana C, Reitemeier RJ, Moertel CG, et al. The natural history of carcinoma of the colon and rectum. Am J Surg 108:826, 1964

    Article  PubMed  CAS  Google Scholar 

  2. Steele G Jr, Ravikumar TS. What’s new in general surgery: resection of hepatic metastases from colorectal cancer: biologic perspectives. Ann Surg 210:127, 1989

    Article  PubMed  Google Scholar 

  3. O’Dwyer PJ, Minnitti CJ. Randomized trials with 5-fluorouracil in the treatment of advanced colorectal cancer. In: Cohen AM, Winawer SJ (eds) Cancer of the Colon, Rectum, and Anus. New York, McGraw-Hill, 1995 pp. 993–947

    Google Scholar 

  4. Moertel CG. Chemotherapy for colorectal cancer. N Engl J Med 330:1136, 1994

    Article  PubMed  CAS  Google Scholar 

  5. Ridge JA, Bading JR, Gelbard AS, et al. Perfusion of colorectal hepatic metastases: relative distribution of flow from the hepatic artery and portal vein. Cancer 59:1547, 1987

    Article  PubMed  CAS  Google Scholar 

  6. Daly JM, Kemeny N, Sigurdson E, Oderman P, Thorn A. Regional infusion for colorectal hepatic metastases: a randomized trial comparing the hepatic artery with the portal vein. Arch Surg 122:1273, 1987

    Article  PubMed  CAS  Google Scholar 

  7. Ensminger WD, Rosowsky A, Raso V, et al. A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2′-deoxyuridine and 5-fluorouracil. Cancer Res 38:3784, 1978

    PubMed  CAS  Google Scholar 

  8. Alexander HR, Bartlett DL, Fraker DL, Libutti SK. Regional treatment strategies for unresectable primary or metastatic cancer confined to the liver. In: PPO Updates. Principles & Practice of Oncology, Vol 10. Philadelphia, Lippincott-Raven, 1996 p. 19

    Google Scholar 

  9. Curley SA, Hohn DC, Roh MS. Hepatic artery infusion pumps: cannulation techniques and other surgical considerations. Langenbecks Arch Chir 375:119, 1990

    Article  PubMed  CAS  Google Scholar 

  10. Curley SA, Roh MS, Chase JL, Hohn DC. Adjuvant hepatic arterial infusion chemotherapy after curative resection of colorectal liver metastases. Am J Surg 166:743, 1993

    Article  PubMed  CAS  Google Scholar 

  11. Fordy C, Burke D, Earlam S. Twort P, Allen-Mersh TG. Treatment interruptions and complications with two continuous hepatic artery floxuridine infusion systems in colorectal liver metastases. Br J Cancer 72:1023, 1995

    Article  PubMed  CAS  Google Scholar 

  12. Curley SA, Chase JL, Roh MS, Hohn DC. Technical considerations and complications associated with the placement of 180 implantable hepatic arterial infusion devices. Surgery 114:928, 1993

    PubMed  CAS  Google Scholar 

  13. Campbell KA, Bums RC, Sitzmann JV, et al. Regional chemotherapy devices: effect of experience and anatomy on complications. J Clin Oncol 11:822, 1993

    PubMed  CAS  Google Scholar 

  14. Civelek AC, Sitzmann JV, Chin BB, et al. Misperfusion of the liver during hepatic artery infusion chemotherapy: value of preoperative angiography and postoperative pump scintigraphy. AJR 160:865, 1993

    PubMed  CAS  Google Scholar 

  15. Balch CM, Urist MM, Soong SJ, McGregor M. A prospective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg 198:567, 1983

    Article  PubMed  CAS  Google Scholar 

  16. Niederhuber JE, Ensminger W, Gyves J, et al. Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer 53:1336, 1984

    Article  PubMed  CAS  Google Scholar 

  17. Sterchi JM, Richards F, White DR, et al. Chemoinfusion of the hepatic artery for metastases to the liver. Surg Gynecol Obstet 168:291 1989

    PubMed  CAS  Google Scholar 

  18. Kemeny N, Daly J, Reichman B, et al. Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma: a randomized trial. Ann Intern Med 107:459, 1987

    PubMed  CAS  Google Scholar 

  19. Martin JK Jr, O’Connell MJ, Wieand HS, et al. Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer: a randomized trial. Arch Surg 125:1022, 1990

    Article  PubMed  Google Scholar 

  20. Rougier P, Laplanche A, Huguier M, et al. Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of a prospective randomized trial. J Clin Oncol 10:1112, 1992

    PubMed  CAS  Google Scholar 

  21. Hohn DC, Stagg RJ, Friedman MA, et al. A randomized trial of continuous intravenous versus hepatic intraarterial floxuridine in patients with colorectal cancer metastatic to the liver: the Northern California Oncology Group trial. J Clin Oncol 7:1646, 1989

    PubMed  CAS  Google Scholar 

  22. Chang AE, Schneider PD, Sugarbaker PH, et al. A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann Surg 206:685, 1987

    Article  PubMed  CAS  Google Scholar 

  23. Allen-Mersh TG, Earlam S, Fordy C, Abrams K, Houghton J. Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases. Lancet 344:1255, 1994

    Article  PubMed  CAS  Google Scholar 

  24. Harmantas A, Rotstein LE, Langer B. Regional versus systemic chemotherapy in the treatment of colorectal carcinoma metastatic to the liver: is there a survival difference? Meta-analysis of the published literature. Cancer 78:1639, 1996

    Article  PubMed  CAS  Google Scholar 

  25. Meta-Analysis Group in Cancer. Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer. J Natl Cancer Inst 88:252, 1996

    Article  Google Scholar 

  26. Kemeny N, Cohen A, Bertino JR, et al. Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma. Cancer 65:2446, 1989

    Article  Google Scholar 

  27. Sugihara K. Continuous hepatic arterial infusion of 5-fluorouracil for unresectable colorectal liver metastases: phase II study. Surgery 117:624, 1995

    Article  PubMed  CAS  Google Scholar 

  28. Stagg RJ, Venook AP, Chase JL, et al. Alternating hepatic intra-arterial floxuridine and fluorouracil: a less toxic regimen for treatment of liver metastases from colorectal cancer. J Natl Cancer Inst 83:423, 1991

    Article  PubMed  CAS  Google Scholar 

  29. Davidson BS, Izzo F, Chase JL, et al. Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity. Am J Surg 172:244, 1996

    Article  PubMed  CAS  Google Scholar 

  30. Kemeny N, Seiter K, Niedzwiecki D, et al. A randomized trial of intrahepatic infusion of fluorodeoxyuridine with dexamethasone versus fluorodeoxyuridine alone in the treatment of metastatic colorectal cancer. Cancer 69:327, 1992

    Article  PubMed  CAS  Google Scholar 

  31. Kemeny N, Seiter K, Conti JA, et al. Hepatic arterial floxuridine and leucovorin for unresectable liver metastases from colorectal carcinoma: new dose schedules and survival update. Cancer 73:1134, 1994

    Article  PubMed  CAS  Google Scholar 

  32. Cortesi E, Capussotti L, Di Tora P, et al. Bolus vs. continuous hepatic arterial infusion of cisplatin plus intravenous 5-fluorouracil chemotherapy for unresectable colorectal metastases. Dis Colon Rectum 37:S138, 1994

    Article  PubMed  CAS  Google Scholar 

  33. Warren HW, Anderson JH, O’Gorman P, et al. A phase II study of regional 5-fluorouracil infusion with intravenous folinic acid for colorectal liver metastases. Br J Cancer 70:677 1994

    Article  PubMed  CAS  Google Scholar 

  34. Kerr DJ, Ledermann JA, McArdle CS, et al. Phase I clinical and pharmacokinetic study of leucovorin and infusional hepatic arterial fluorouracil. J Clin Oncol 13:2968, 1995

    PubMed  CAS  Google Scholar 

  35. Hohenberger P, Schlag P, Herrmann R, Räth U. Intrahepatic 5-FU retreatment of liver metastases of colorectal cancer that were progressive under previous systemic chemotherapy. Am J Clin Oncol 12:447, 1989

    Article  PubMed  CAS  Google Scholar 

  36. Kemeny N, Cohen A, Seiter K, et al. Randomized trial of hepatic arterial floxuridine, mitomycin, and carmustine versus floxuridine alone in previously treated patients with liver metastases from colorectal cancer. J Clin Oncol 11:330, 1993

    PubMed  CAS  Google Scholar 

  37. Vaughty JN, March RDW, Cendan JC, Chu NM, Copeland EM. Arterial therapy of hepatic colorectal metastasis. Br J Surg 83:447, 1996

    Article  Google Scholar 

  38. Patt Y, Hoque A, Lozano R, et al. Phase II trial of hepatic arterial infusion of fluorouracil and recombinant human interferon alfa-2b for liver metastases of colorectal cancer refractory to systemic fluorouracil and leucovorin. J Clin Oncol 15:1432, 1997

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Lee M. Ellis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Judy Chase
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yehuda Patt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Steven A. Curley
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Gastrointestinal Tumor Surgery, Department of Surgical Oncology, Division of Surgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Steven A. Curley M.D. (Professor of Surgery, Chief) (Professor of Surgery, Chief)

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ellis, L.M., Chase, J., Patt, Y., Curley, S.A. (1998). Hepatic Arterial Infusion Chemotherapy for Colorectal Cancer Metastasis to the Liver. In: Curley, S.A. (eds) Liver Cancer. M.D. Anderson Solid Tumor Oncology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1666-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1666-7_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7236-6

  • Online ISBN: 978-1-4612-1666-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation