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Extrinsic Factors Affecting Sperm Motility: Immunological and Infectious Factors and Reactive Oxygen Species

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Male Sterility and Motility Disorders

Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Sperm motility requires the interaction of intracellular factors, including an adequate level of adenosine triphosphate (ATP), functional axonemal dynein ATPases, and an intact axoneme bathing in a proper ionic environment. These factors also represent the minimal conditions required to initiate and maintain the motility of modeled spermatozoa (i.e., spermatozoa demembranated by a detergent treatment in which motility is initiated by the addition of ATP and ions (1-4). Extracellular factors that affect these minimal requirements will cause an arrest in sperm motility. Factors such as sperm agglutinating antibodies that act at the surface of cells by forming a physical network of spermatozoa bound to each other obviously act via different mechanisms. This chapter will not cover the effects of sperm immobilizing or agglutinating antibodies on sperm motility, but it will focus on the actions of factors, such as infections, proteins of the immune system, polymorphonuclear leukocytes, and reactive oxygen species (ROS).

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Authors
  1. Claude Gagnon
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  2. Eve De Lamirande
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Editor information

Editors and Affiliations

  1. Service de FIV, Hôpital A. Béclère, 92141, Clamart cedex, France

    Samir Hamamah Ph.D.

  2. Service de Gynéco-Obstétrique, Hôpital A. Béclère, 157, rue de la Porte-de-Trivaux, 92141, Clamart cedex, France

    François Olivennes M.D., Ph.D.  & René Frydman Ph.D.  & 

  3. Centre de Stérilité Masculine, Hôpital de la Grave, 31052, Toulouse cedex, France

    Roger Mieusset M.D.

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© 1999 Springer Science+Business Media New York

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Gagnon, C., De Lamirande, E. (1999). Extrinsic Factors Affecting Sperm Motility: Immunological and Infectious Factors and Reactive Oxygen Species. In: Hamamah, S., Olivennes, F., Mieusset, R., Frydman, R. (eds) Male Sterility and Motility Disorders. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1522-6_3

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  • DOI: https://doi.org/10.1007/978-1-4612-1522-6_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7177-2

  • Online ISBN: 978-1-4612-1522-6

  • eBook Packages: Springer Book Archive

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