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Kaposi’s Sarcoma—Associated Human Herpes Virus Eight: Localization of Viral Gene Expression and Viral Latency

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Techniques in Quantification and Localization of Gene Expression

Abstract

Kaposi’s sarcoma (KS) is recognized as an AIDS-associated malignancy among male homosexuals. Epidemiological evidence suggests that human immunodeficiency virus type 1 (HIV)-associated KS may be due to a sexually transmitted pathogen distinct from HIV and associated with homosexual transmission [1]. While HIV infection strongly predisposes to KS, HIV itself is not a likely candidate for this agent because KS occurs in individuals who are not infected with HIV [2, 3].

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References

  1. Peterman TA, Jaffe HW, Beral V. Epidemiologic clues to the etiology of Kaposi’s sarcoma. AIDS 1993; 7: 605–611.

    Article  PubMed  CAS  Google Scholar 

  2. Taylor JF, Smith PG, Bull D, Pike MC. Kaposi’s sarcoma in Uganda: geographic and ethnic destribution. Br J Cancer 1972; 2: 483–497.

    Article  Google Scholar 

  3. Harwood AR, Osoba D, Hofstader SL, Goldstein MB, Cardella CJ, Holecek MJ, Kunynetz R, Giammarco RA. Kaposi’s sarcoma in recipients of renal transplants. Am J Med 1979; 67: 759–765.

    Article  PubMed  CAS  Google Scholar 

  4. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related boby cavity-based lymphoma. N Engl J Med 1995; 332: 1186–1191.

    Article  PubMed  CAS  Google Scholar 

  5. Moore PS, Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma in patients with and those without HIV infection. N Engl J Med 1995; 332: 1181–1185.

    Article  PubMed  CAS  Google Scholar 

  6. Moore PS, Gao SJ, Dominguez G, Cesarman E, Lungu O, Knowles DM, Barber R, Pellett PE, McGeoch DJ, Chang Y. Primary characterization of a herpesvirus agent associated with Kaposi’s sarcomae. J Virol 1996; 70: 549–558.

    PubMed  CAS  Google Scholar 

  7. Miller G, Rigsby MO, Heston L, Grogan E, Sun R, Metroka C, Levy JA, Gao SJ, Chang Y, Moore P. Antibodies to butyrate-inducible antigens of Kaposi’s sarcoma associated herpesvirus in patients with HIV-1 infection. N Engl J Med 1996; 334: 1292–1297.

    Article  PubMed  CAS  Google Scholar 

  8. Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nature Med 1996; 2: 918–924.

    Article  PubMed  CAS  Google Scholar 

  9. Weiss RA. Human herpesvirus 8 in lymphoma and Kaposi’s sarcoma: now the virus can be propagated. Nature Med 1996; 2: 277–278.

    Article  PubMed  CAS  Google Scholar 

  10. Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi’s sarcoma associated herpesvirus-related latent nuclear antigens before the development of Kaposi’s sarcoma. N Engl J Med 1996; 335: 233–241.

    Article  PubMed  CAS  Google Scholar 

  11. Whitby D, Howard MR, Tenant-Flowers M, Brink NS, Copas A, Boshoff C, Hatzioannou T, Suggett FE, Aldam DM, Denton AS, Miller RF, Weller IVD, Weiss RA, Tedder RS, Schulz TS. Detection of Kaposi’s sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi’s sarcoma. Lancet 1995; 346: 799–802.

    Article  PubMed  CAS  Google Scholar 

  12. Koelle DM, Huang M-L, Chandran B, Vieira J, Piepkorn M, Corey L. Frequent detection of Kaposi’s sarcoma associated herpesvirus (HHV-8) in saliva of human immunodeficiency virus infected men: clinical and immunologic correlates. J Infect Dis 1997; 176: 94–102.

    Article  PubMed  CAS  Google Scholar 

  13. Cone R, Huang ML, Ashley R, Corey L. Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. J Clin Microbiol 1993; 31: 1262–1267.

    PubMed  CAS  Google Scholar 

  14. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266: 1865–1869.

    Article  PubMed  CAS  Google Scholar 

  15. Smith MS, Bloomer C, Horvat R, Goldstein E, Casparian JM, Chandran B. Detection of human herpesvirus 8 DNA in Kaposi’s sarcoma lesions and peripheral blood of human immunodeficiency virus-positive patients and correlation with serologic results. J Infect Dis 1997; 176: 84–93.

    Article  PubMed  CAS  Google Scholar 

  16. Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D. Lytic growth of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nature Med 1996; 2: 342–346.

    Article  PubMed  CAS  Google Scholar 

  17. Foreman KE, Friborg J Jr, Kong WP, Woffendin C, Polverini PJ, Nickoloff BJ, Nabel GJ. Propagation of a human herpesvirus from AIDS-associated Kaposi’s sarcoma. N Engl J Med 1997; 336: 163–171.

    Article  PubMed  CAS  Google Scholar 

  18. Brodie SJ, Bardsley KD, Mecham JO, Diem K, Norelius SE, Wilson WC. Epizootic hemorrhagic disease: analysis of tissues by amplification and in situ hybridization reveals widespread orbivirus infection at low copy number. J Virol 1998; 72: 3863–3871.

    PubMed  CAS  Google Scholar 

  19. Zhong W, Wang H, Herndier B, Ganem D. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci USA 1996; 93: 6641–6646.

    Article  PubMed  CAS  Google Scholar 

  20. Beral V, Bull D, Darby S, Weller I, Carne C, Beecham M, Jaffe H. Risk of Kaposi’s sarcoma and sexual practices associated with faecal contact in homosexual or bisexual men with AIDS. Lancet 1992; 339: 632–635.

    Article  PubMed  CAS  Google Scholar 

  21. Ambroziak JA, Blackbourn DJ, Herndier BG, Glogau RG, Gullett JH, McDonald AR, Lennette ET, Levy JA. Herpes-like sequences in HIV-infected and uninfected Kaposi’s sarcoma patients. Science 1995; 268: 582–583.

    Article  PubMed  CAS  Google Scholar 

  22. Huang YQ, Li JJ, Kaplan MH, Poiesz B, Katabira E, Zhang WC, Feiner D, Friedman-Kien AE. Human herpesvirus-like nucleic acid in various forms of Kaposi’s sarcoma. Lancet 1995; 345: 759–761.

    Article  PubMed  CAS  Google Scholar 

  23. Schalling M, Ekman M, Kaaya EE, Linde A, Biberfeld P. A role for a new herpesvirus (KSHV) in different forms of Kaposi’s sarcoma. Nature Med 1995; 1: 707–708.

    Article  PubMed  CAS  Google Scholar 

  24. Rettig MB, Ma HJ, Vescio RA, Pold M, Schiller G, Belson D, Savage A, Nishikubo C, Wu C, Fraser J, Said JW, Berenson JR. Kaposi’s sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 1997; 276: 1851–1854.

    Article  PubMed  CAS  Google Scholar 

  25. Zhong W, Ganem D. Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8). J Virol 1997; 71: 1207–1212

    PubMed  CAS  Google Scholar 

  26. Staskus KA, Zhong W, Gebhard K, Herndier B, Wang H, Renne R, Beneke J, Pudney J, Anderson DJ, Ganem D, Haase AT. Kaposi’s sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 1997; 71: 715–719.

    PubMed  CAS  Google Scholar 

  27. Monini P, De Lellis L, Fabris M, Rigolin F, Cassai E. Kaposi’s sarcoma-associated herpesvirus DNA sequences in prostate tissue and human semen. N Engl J Med 1996; 334: 1168–1172.

    Article  PubMed  CAS  Google Scholar 

  28. Blackbourn DJ, Levy JA. Human herpesvirus 8 in semen and prostate. AIDS 1997; 11: 249–250.

    Article  PubMed  CAS  Google Scholar 

  29. Lebbe C, Pellet C, Tatoud R, Agbalika F, Dosquet P, Desgrez JP, Morel P, Calvo F. Absence of human herpesvirus 8 sequences in prostate specimens. AIDS 1997; 11: 270.

    PubMed  CAS  Google Scholar 

  30. Griffiths PD. Herpesviruses and AIDS. J Antimicrob Chemother 1996; 37: 87–95.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Scott J. Brodie
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  2. John N. Krieger
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  3. Catherine Diamond
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  4. Kurt Diem
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  5. Lawrence Corey
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Editor information

Editors and Affiliations

  1. Laboratory of Viral Pathogenesis, Department of Pediatrics, Division of Special Infectious Diseases, Children’s Memorial Hospital, 2300 Children’s Plaza, Chicago, IL, 60614, USA

    Bruce K. Patterson M.D.

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Brodie, S.J., Krieger, J.N., Diamond, C., Diem, K., Corey, L. (2000). Kaposi’s Sarcoma—Associated Human Herpes Virus Eight: Localization of Viral Gene Expression and Viral Latency. In: Patterson, B.K. (eds) Techniques in Quantification and Localization of Gene Expression. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1342-0_7

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  • DOI: https://doi.org/10.1007/978-1-4612-1342-0_7

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-7103-1

  • Online ISBN: 978-1-4612-1342-0

  • eBook Packages: Springer Book Archive

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