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Growth Hormone: The Visible Difference in Burn Care

  • Conference paper
GHRH, GH, and IGF-I

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

The response to a large burn is characterized by increased basal metabolic rate, elevated core temperature, hyperdynamic circulation, protein catabolism, futile substrate cycling, marked lipolysis, loss of lean body mass, increased susceptibility to infection, and poor wound healing. This is known as the stress response, and the nervous system plays a major role in its pathophysiology (1-14). The limbic system is activated by fear, emotion, and thalamic relay of peripheral nocioceptive stimuli (15). Inflammatory mediators and various cytokines, such as bacterial endotoxin, interleukin-1, and tumor necrosis factor a, stimulate the hypothalamus directly (16-20). They increase the thermoregulatbry set point and alter endocrine function (21-23).

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Authors
  1. Michael J. Muller
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  2. Thomas C. Rutan
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  3. David N. Herndon
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Editor information

Editors and Affiliations

  1. Division of Endocrinology and Metabolism Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA

    Marc R. Blackman M.D.

  2. Division of Geriatric Medicine and Gerontology Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA

    Jesse Roth M.D.  & Jay R. Shapiro M.D.  & 

  3. Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    S. Mitchell Harman M.D., Ph.D.

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© 1995 Springer Science+Business Media New York

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Muller, M.J., Rutan, T.C., Herndon, D.N. (1995). Growth Hormone: The Visible Difference in Burn Care. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_8

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  • DOI: https://doi.org/10.1007/978-1-4612-0807-5_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6908-3

  • Online ISBN: 978-1-4612-0807-5

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