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Angiogenesis in Mammary Tumors: Quantitation and Relation to Prognosis

  • Chapter
Vascular Morphogenesis in the Female Reproductive System

Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

Abstract

Angiogenesis is the generation of new vessels from the existing vasculature and is essential for tumor growth and metastasis. This requisite increase in tumor vascularity has been recognized for many centuries. Indeed the tumor vasculature was described posthumously by John Hunter in 1794 who noted, “In a disease in which there is an increase in the part, as in tumors, the increase in the vessels is conspicuous.” However, it is only since Folkman’s (1971) hypothesis on antiangiogenesis that a quantitative method for measuring angiogenesis has been pursued.

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  1. Stephen B. Fox
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Editors and Affiliations

  1. Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, D-79106, Germany

    Hellmut G. Augustin

  2. Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria, 3168, Australia

    Peter A. W. Rogers

  3. Molecular Biology Institute, University of California, Los Angeles, CA, 90095-1570, USA

    M. Luisa Iruela-Arispe

  4. Department of Obstetrics and Gynaecology, Rosie Maternity Hospital, Cambridge, CB2 2SW, England

    Stephen K. Smith

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Fox, S.B. (2001). Angiogenesis in Mammary Tumors: Quantitation and Relation to Prognosis. In: Augustin, H.G., Rogers, P.A.W., Iruela-Arispe, M.L., Smith, S.K. (eds) Vascular Morphogenesis in the Female Reproductive System. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0213-4_4

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