Abstract
Air Pollution has been associated with significant adverse health effects leading to increased morbidity and mortality. Cumulative epidemiological and experimental data have shown that exposure to air pollutants leads to increased cardiovascular ischemic events and enhanced atherosclerosis. The strongest associations are with the particulate matter (PM) components of air pollution, and it appears that the smaller particles are more pathogenic and have a greater ability to induce systemic vascular effects. Although it is unclear how the exposure to air pollutants can affect the systemic vasculature, it is likely that various mechanistic pathways participate including the induction of systemic pro-oxidant and pro-inflammatory responses which are now thought to play a central role. Air pollutants lead to oxidative alterations of plasma lipoproteins that increase the atherogenicity of low-density lipoproteins (LDL) and decrease the protective effects of high-density lipoproteins (HDL). This chapter reviews the epidemiological, clinical and experimental animal evidence that support the association of air pollutants with systemic pro-oxidant effects resulting in alteration of plasma lipoproteins and enhanced atherosclerosis.
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References
Adar SD, Klein R, Klein BE, Szpiro AA, Cotch MF, Wong TY, O’Neill MS et al (2010) Air pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based multi-ethnic study of atherosclerosis (MESA). PLoS Med 7:e1000372
Adar SD, Sheppard L, Vedal S, Polak JF, Sampson PD, Diez Roux AV, Budoff M, Jacobs DR Jr, Barr RG, Watson K, Kaufman JD (2013) Fine particulate air pollution and the progression of carotid intima-medial thickness: a prospective cohort study from the multi-ethnic study of atherosclerosis and air pollution. PLoS Med 10(4):e1001430
Alfaro-Moreno E, Martinez L, Garcia-Cuellar C, Bonner JC, Murray JC, Rosas I, Rosales SP et al (2002) Biologic effects induced in vitro by PM10 from three different zones of Mexico City. Environ Health Perspect 110:715–720
Allen RW, Criqui MH, Diez Roux AV, Allison M, Shea S, Detrano R, Sheppard L, Wong ND, Stukovsky KH, Kaufman JD (2009) Fine particulate matter air pollution, proximity to traffic, and aortic atherosclerosis. Epidemiology 20(2):254–264
Amakawa K, Terashima T, Matsuzaki T, Matsumaru A, Sagai M, Yamaguchi K (2003) Suppressive effects of diesel exhaust particles on cytokine release from human and murine alveolar macrophages. Exp Lung Res 29:149–164
Andre E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, Lentner B et al (2006) Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung. Eur Respir J 28:275–285
Ansell BJ, Navab M, Hama S, Kamranpour N, Fonarow G, Hough G, Rahmani S et al (2003) Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment. Circulation 108:2751–2756
Araujo J (2011) Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis. Air Qual Atmos Health 4:79–93
Araujo JA, Nel AE (2009) Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress. Part Fibre Toxicol 6:24
Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE (2008) Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res 102(5):589–596
Araujo JA, Zhang M, Yin F (2012) Heme oxygenase-1, oxidation, inflammation, and atherosclerosis. Front Pharmacol 3:119
Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM et al (2008) Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential. A workshop report and consensus statement. Inhal Toxicol 20:75–99
Bai Y, Suzuki AK, Sagai M (2001) The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species. Free Radic Biol Med 30:555–562
Bai N, Kido T, Suzuki H, Yang G, Kavanagh TJ, Kaufman JD, Rosenfeld ME, van Breemen C, Eeden SF (2011) Changes in atherosclerotic plaques induced by inhalation of diesel exhaust. Atherosclerosis 216(2):299–306
Bauer M, Moebus S, Mohlenkamp S, Dragano N, Nonnemacher M, Fuchsluger M, Kessler C, Jakobs H, Memmesheimer M, Erbel R, Jockel KH, Hoffmann B (2010) Urban particulate matter air pollution is associated with subclinical atherosclerosis: results from the HNR (Heinz Nixdorf Recall) study. J Am Coll Cardiol 56(22):1803–1808
Becker S, Mundandhara S, Devlin RB, Madden M (2005a) Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies. Toxicol Appl Pharmacol 207:269–275
Becker S, Dailey L, Soukup JM, Silbajoris R, Devlin RB (2005b) TLR-2 is involved in airway epithelial cell response to air pollution particles. Toxicol Appl Pharmacol 203:45–52
Bhatnagar A (2006) Environmental cardiology: studying mechanistic links between pollution and heart disease. Circ Res 99:692–705
Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, Luepker R et al (2004) Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation 109:2655–2671
Brook RD, Rajagopalan S, Pope CA III, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F et al (2010) Particulate matter air pollution and cardiovascular disease. An update to the scientific statement from the American Heart Association. Circulation 121:2331–2378
Brown DM, Donaldson K, Stone V (2004) Effects of PM10 in human peripheral blood monocytes and J774 macrophages. Respir Res 5:29
Campen MJ, Lund AK, Knuckles TL, Conklin DJ, Bishop B, Young D, Seilkop S, Seagrave J, Reed MD, McDonald JD (2010) Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(-/-) mice. Toxicol Appl Pharmacol 242(3):310–317
Chen LC, Nadziejko C (2005) Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal Toxicol 17(4–5):217–224
Chen LC, Quan C, Hwang JS, Jin X, Li Q, Zhong M, Rajagopalan S, Sun Q (2010) Atherosclerosis lesion progression during inhalation exposure to environmental tobacco smoke: a comparison to concentrated ambient air fine particles exposure. Inhal Toxicol 22(6):449–459
Chio C-P, Chen S-C, Chiang K-C, Chou W-C, Liao C-M (2007) Oxidative stress risk analysis for exposure to diesel exhaust particle-induced reactive oxygen species. Sci Total Environ 387:113–127
Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS (2007) The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med 176:370–376
Chuang GC, Yang Z, Westbrook DG, Pompilius M, Ballinger CA, White CR, Krzywanski DM et al (2009) Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol 297:L209–L216
Delfino RJ, Staimer N, Tjoa T, Polidori A, Arhami M, Gillen DL, Kleinman MT et al (2008) Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease. Environ Health Perspect 116:898–906
Diez Roux AV, Auchincloss AH, Franklin TG, Raghunathan T, Barr RG, Kaufman J, Astor B, Keeler J (2008) Long-term exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 167(6):667–675
Dubowsky SD, Suh H, Schwartz J, Coull BA, Gold DR (2006) Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation. Environ Health Perspect 114:992–998
Fujii T, Hayashi S, Hogg JC, Mukae H, Suwa T, Goto Y, Vincent R et al (2002) Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow. Am J Respir Cell Mol Biol 27:34–41
Goldsmith CA, Imrich A, Danaee H, Ning YY, Kobzik L (1998) Analysis of air pollution particulate-mediated oxidant stress in alveolar macrophages. J Toxicol Environ Health A 54:529–545
Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S et al (2007) Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biol 8:R149
Gunnison A, Chen LC (2005) Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. VI. Gene expression in heart and lung tissue. Inhal Toxicol 17:225–233
Heidenfelder BL, Reif DM, Harkema JR, Cohen Hubal EA, Hudgens EE, Bramble LA, Wagner JG et al (2009) Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates. Toxicol Sci 108:207–221
Hirano S, Furuyama A, Koike E, Kobayashi T (2003) Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells. Toxicology 187:161–170
Hiura TS, Kaszubowski MP, Li N, Nel AE (1999) Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 163:5582–5591
Hoffmann B, Moebus S, Mohlenkamp S, Stang A, Lehmann N, Dragano N, Schmermund A, Memmesheimer M, Mann K, Erbel R, Jockel KH (2007) Residential exposure to traffic is associated with coronary atherosclerosis. Circulation 116(5):489–496
Hoyert DL, Xu J (2012) Deaths: preliminary data for 2011. Natl Vital Stat Rep 61:1–52
Imrich A, Ning Y, Lawrence J, Coull B, Gitin E, Knutson M, Kobzik L (2007) Alveolar macrophage cytokine response to air pollution particles: oxidant mechanisms. Toxicol Appl Pharmacol 218:256–264
Ishii H, Hayashi S, Hogg JC, Fujii T, Goto Y, Sakamoto N, Mukae H et al (2005) Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment. Respir Res 6:87
Ito T, Suzuki T, Tamura K, Nezu T, Honda K, Kobayashi T (2008) Examination of mRNA expression in rat hearts and lungs for analysis of effects of exposure to concentrated ambient particles on cardiovascular function. Toxicology 243:271–283
Jimenez LA, Drost EM, Gilmour PS, Rahman I, Antonicelli F, Ritchie H, MacNee W et al (2002) PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha. Am J Physiol Lung Cell Mol Physiol 282:L237–L248
Kampfrath T, Maiseyeu A, Ying Z, Shah Z, Deiuliis JA, Xu X, Kherada N et al (2011) Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res 108(6):716–726
Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC et al (2011) Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med 364:127–135
Kunzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L, Gilliland F, Thomas D, Peters J, Hodis HN (2005) Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect 113(2):201–206
Kunzli N, Jerrett M, Garcia-Esteban R, Basagana X, Beckermann B, Gilliland F, Medina M, Peters J, Hodis HN, Mack WJ (2010) Ambient air pollution and the progression of atherosclerosis in adults. PLoS ONE 5(2):e9096
Lee CC, Kang JJ (2002) Extract of motorcycle exhaust particles induced macrophages apoptosis by calcium-dependent manner. Chem Res Toxicol 15:1534–1542
Lei YC, Chen MC, Chan CC, Wang PY, Lee CT, Cheng TJ (2004) Effects of concentrated ambient particles on airway responsiveness and pulmonary inflammation in pulmonary hypertensive rats. Inhal Toxicol 16:785–792
Lewis JG, Graham DG, Valentine WM, Morris RW, Morgan DL, Sills RC (1999) Exposure of C57BL/6 mice to carbon disulfide induces early lesions of atherosclerosis and enhances arterial fatty deposits induced by a high fat diet. Toxicol Sci 49:124–132
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M et al (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455–460
Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N et al (2004) Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol 173:3467–3481
Li Z, Hyseni X, Carter JD, Soukup JM, Dailey LA, Huang YC (2006) Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol 291:C357–C365
Li R, Ning Z, Majumdar R, Cui J, Takabe W, Jen N, Sioutas C et al (2010) Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling. Part Fibre Toxicol 7:6
Li R, Navab M, Pakbin P, Ning Z, Navab K, Hough G, Morgan TE, Finch CE, Araujo JA, Fogelman AM, Sioutas C, Hsiai T (2013) Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice. J Lipid Res 54(6):1608–1615
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, AlMazroa MA et al (2012) A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2224–2260
Lippmann M, Chen LC, Gordon T, Ito K, Thurston GD (2013) National Particle Component Toxicity (NPACT) Initiative: integrated epidemiologic and toxicologic studies of the health effects of particulate matter components. Res Rep Health Eff Inst 177:5–13
Liu L, Ruddy T, Dalipaj M, Poon R, Szyszkowicz M, You H, Dales RE et al (2009) Effects of indoor, outdoor, and personal exposure to particulate air pollution on cardiovascular physiology and systemic mediators in seniors. J Occup Environ Med 51:1088–1098
Lund AK, Knuckles TL, Obot Akata C, Shohet R, McDonald JD, Gigliotti A, Seagrave JC et al (2007) Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol Sci 95:485–494
Lund AK, Lucero J, Lucas S, Madden MC, McDonald JD, Seagrave JC, Knuckles TL, Campen MJ (2009) Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways. Arterioscler Thromb Vasc Biol 29(4):511–517
Lund AK, Lucero J, Harman M, Madden MC, McDonald JD, Seagrave JC, Campen MJ (2011) The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissions. Am J Respir Crit Care Med 184(1):82–91
Lusis AJ (2000) Atherosclerosis. Nature 407:233–241
Medina-Navarro R, Lifshitz A, Wacher N, Hicks JJ (1997) Changes in human serum antioxidant capacity and peroxidation after four months of exposure to air pollutants. Arch Med Res 28:205–208
Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, Kaufman JD (2007) Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 356:447–458
Mo Y, Wan R, Chien S, Tollerud DJ, Zhang Q (2009) Activation of endothelial cells after exposure to ambient ultrafine particles: the role of NADPH oxidase. Toxicol Appl Pharmacol 236:183–193
Moller P, Loft S (2010) Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution. Environ Health Perspect 118(8):1126–1136
Monn C, Becker S (1999) Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM2.5) and coarse particles (PM10-2.5) in outdoor and indoor air. Toxicol Appl Pharmacol 155:245–252
Montiel-Davalos A, Alfaro-Moreno E, Lopez-Marure R (2007) PM2.5 and PM10 induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells. Inhal Toxicol 19(Suppl 1):91–98
Montiel-Davalos A, Ibarra-Sanchez Mde J, Ventura-Gallegos JL, Alfaro-Moreno E, Lopez-Marure R (2010) Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter. Toxicol In Vitro 24:135–141
Morishita M, Keeler G, Wagner J, Marsik F, Timm E, Dvonch J, Harkema J (2004) Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit. Inhal Toxicol 16:663–674
Mustafic H, Jabre P, Caussin C, Murad MH, Escolano S, Tafflet M, Perier MC et al (2012) Main air pollutants and myocardial infarction: a systematic review and meta-analysis. JAMA 307:713–721
Mutlu GM, Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW et al (2007) Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest 117:2952–2961
Niwa Y, Hiura Y, Murayama T, Yokode M, Iwai N (2007) Nano-sized carbon black exposure exacerbates atherosclerosis in LDL-receptor knockout mice. Circ J 71(7):1157–1161
Ntziachristos L, Froines J, Cho A, Sioutas C (2007) Relationship between redox activity and chemical speciation of size-fractionated particulate matter. Part Fibre Toxicol 4:5
Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA (2004) Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 112:1299–1306
Nurkiewicz TR, Porter DW, Barger M, Millecchia L, Rao KM, Marvar PJ, Hubbs AF et al (2006) Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure. Environ Health Perspect 114:412–419
Ohyama M, Otake T, Adachi S, Kobayashi T, Morinaga K (2007) A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Inhal Toxicol 19(Suppl 1):157–160
Osornio-Vargas AR, Bonner JC, Alfaro-Moreno E, Martinez L, Garcia-Cuellar C, Ponce-de-Leon Rosales S, Miranda J et al (2003) Proinflammatory and cytotoxic effects of Mexico City air pollution particulate matter in vitro are dependent on particle size and composition. Environ Health Perspect 111:1289–1293
Patel PJ, Khera AV, Jafri K, Wilensky RL, Rader DJ (2011) The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease. J Am Coll Cardiol 58:2068–2075
Pope CA 3rd, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD (2002) Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 287:1132–1141
Pope CA 3rd, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ (2004) Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 109:71–77
Pozzi R, De Berardis B, Paoletti L, Guastadisegni C (2003) Inflammatory mediators induced by coarse (PM2.5-10) and fine (PM2.5) urban air particles in RAW 264.7 cells. Toxicology 183:243–254
Quan C, Sun Q, Lippmann M, Chen LC (2010) Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction. Inhal Toxicol 22(9):738–753
Ruckerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdorster G, Wichmann HE et al (2007) Ultrafine particles and platelet activation in patients with coronary heart disease – results from a prospective panel study. Part Fibre Toxicol 4:1
Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, Diaz E et al (2002) Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am J Respir Crit Care Med 165:1610–1617
Sanchez-Rodriguez MA, Retana-Ugalde R, Ruiz-Ramos M, Munoz-Sanchez JL, Vargas-Guadarrama LA, Mendoza-Nunez VM (2005) Efficient antioxidant capacity against lipid peroxide levels in healthy elderly of Mexico City. Environ Res 97:322–329
Shah ASV, Langrish JP, Nair H, McAllister DA, Hunter AL, Donaldson K, Newby DE et al (2013) Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet 382:1039–1048
Soares SR, Carvalho-Oliveira R, Ramos-Sanchez E, Catanozi S, da Silva LF, Mauad T, Gidlund M, Goto H, Garcia ML (2009) Air pollution and antibodies against modified lipoproteins are associated with atherosclerosis and vascular remodeling in hyperlipemic mice. Atherosclerosis 207(2):368–373
Sorensen M, Daneshvar B, Hansen M, Dragsted LO, Hertel O, Knudsen L, Loft S (2003) Personal PM2.5 exposure and markers of oxidative stress in blood. Environ Health Perspect 111:161–166
Soukup JM, Ghio AJ, Becker S (2000) Soluble components of Utah Valley particulate pollution alter alveolar macrophage function in vivo and in vitro. Inhal Toxicol 12:401–414
Stocker R, Keaney JF Jr (2004) Role of oxidative modifications in atherosclerosis. Physiol Rev 84:1381–1478
Sumanasekera WK, Ivanova MM, Johnston BJ, Dougherty SM, Sumanasekera GU, Myers SR, Ali Y et al (2007) Rapid effects of diesel exhaust particulate extracts on intracellular signaling in human endothelial cells. Toxicol Lett 174:61–73
Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, Aguinaldo JG, Fayad ZA, Fuster V, Lippmann M, Chen M, Rajagopalan S (2005) Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 294(23):3003–3010
Sun Q, Yue P, Kirk RI, Wang A, Moatti D, Jin X, Lu B, Schecter AD, Lippmann M, Gordon T, Chen LC, Rajagopalan S (2008) Ambient air particulate matter exposure and tissue factor expression in atherosclerosis. Inhal Toxicol 20(2):127–137
Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, Cai Y et al (2009) Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538–546
Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, van Eeden SF (2002) Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol 39(6):935–942
Tamagawa E, Bai N, Morimoto K, Gray C, Mui T, Yatera K, Zhang X et al (2008) Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. Am J Physiol Lung Cell Mol Physiol 295:L79–L85
Towfighi A, Saver JL (2011) Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke 42:2351–2355
U.S.EPA (2004) Air quality criteria for particulate matter, Final report, Oct 2004. U.S. Environmental Protection Agency, Washington, DC, EPA 600/P-99/002aF-bF
van Eeden SF, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T, Qui D et al (2001) Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)). Am J Respir Crit Care Med 164:826–830
Van Lenten BJ, Wagner AC, Navab M, Anantharamaiah GM, Hama S, Reddy ST, Fogelman AM (2007) Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits. J Lipid Res 48:2344–2353
Vedal S, Campen MJ, McDonald JD, Larson TV, Sampson PD, Sheppard L, Simpson CD et al (2013) National Particle Component Toxicity (NPACT) initiative report on cardiovascular effects. Res Rep Health Eff Inst 178:5–8
Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewardena SN, Grabavoy A et al (2008) Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. Environ Health Perspect 116:1500–1508
Wise H, Balharry D, Reynolds LJ, Sexton K, Richards RJ (2006) Conventional and toxicogenomic assessment of the acute pulmonary damage induced by the instillation of Cardiff PM10 into the rat lung. Sci Total Environ 360:60–67
World Health Organization (2013) World health statistics. World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
World Health Organization (2014) Burden of disease from ambient air pollution for 2012. Public Health, Social and Environmental Determinants of Health Department, World Health Organization, Geneva, Switzerland
Yatera K, Hsieh J, Hogg JC, Tranfield E, Suzuki H, Shih CH, Behzad AR, Vincent R, van Eeden SF (2008) Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques. Am J Physiol Heart Circ Physiol 294(2):H944–H953
Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA (2013) Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. Arterioscler Thromb Vasc Biol 33(6):1153–1161
Ying Z, Kampfrath T, Thurston G, Farrar B, Lippmann M, Wang A, Sun Q, Chen LC, Rajagopalan S (2009) Ambient particulates alter vascular function through induction of reactive oxygen and nitrogen species. Toxicol Sci 111(1):80–88
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Writing of this article was supported by the National Institute of Environmental Health Sciences, National Institutes of Health (ONES RO1 Award ES016959 to Jesus A. Araujo).
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Araujo, J.A., Rosenfeld, M.E. (2015). Air Pollution, Lipids and Atherosclerosis. In: Nadadur, S., Hollingsworth, J. (eds) Air Pollution and Health Effects. Molecular and Integrative Toxicology. Springer, London. https://doi.org/10.1007/978-1-4471-6669-6_9
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