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Air Pollution and Chronic Obstructive Airway Disease

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Air Pollution and Health Effects

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

Chronic obstructive airway disease (COPD) is a major cause of disability, and it’s the third leading cause of death in the United States. It is a progressive condition characterized by exacerbations and remissions of coughing, mucus production, shortness of breath, wheezing, chest tightness, and other symptoms. Pathologically, COPD is manifested in emphysema and/or chronic bronchitis. The leading cause of COPD is tobacco smoking. However, emerging epidemiologic evidence suggests that long-term exposure to air pollution also contributes to the symptoms of COPD. While the disease is progressive, it develops slowly and the underlying mechanisms are unclear. This chapter investigates the role of air pollution in COPD and the cellular-molecular pathways of pollutant-caused pathological changes.

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  1. Translational Lung Biology Center, Pulmonary, Critical Care and Sleep Medicine, University of California, 6510 GBSF, One Shields Avenue, Davis, CA, 95616, USA

    Angela Haczku M.D., Ph.D.

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  1. Imre Redai M.D., F.R.C.A.
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  1. Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Srikanth S. Nadadur

  2. Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Ohio State University, Columbus, Ohio, USA

    John W. Hollingsworth

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Redai, I., Haczku, A. (2015). Air Pollution and Chronic Obstructive Airway Disease. In: Nadadur, S., Hollingsworth, J. (eds) Air Pollution and Health Effects. Molecular and Integrative Toxicology. Springer, London. https://doi.org/10.1007/978-1-4471-6669-6_5

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