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Impacts of Air Pollution on Reproductive Health

  • Chapter
Air Pollution and Health Effects

Abstract

Epidemiologic and experimental evidences converge to indicate that air pollution, at the current levels, play a deleterious role on reproductive health. Higher levels of air pollution are found in developing and underdeveloped countries in regions with high population density and higher fertility rates and although the risks associated with the negative reproductive outcomes tend to be small, the number of people that might be affected is significantly large. In this chapter we review the major epidemiological findings (decreased fertility, adverse gestational outcomes, reproductive system cancer, low vitamin D and immune system alterations), current experimental evidence, and possible molecular mechanisms involved in the impairment of the reproductive health and gestation associated with exposures to common urban air pollution.

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References

  • Amdur MO, Corn M (1963) The irritant potency of zinc ammonium sulfate of different particle sizes. Am Ind Hyg Assoc J 24:326–333

    Google Scholar 

  • Amdur MO, Creasia DA (1966) The irritant potency of m-terphenyl of different particle sizes. Am Ind Hyg Assoc J 27(4):349–352

    CAS  PubMed  Google Scholar 

  • Andrysík Z, Vondráček J, Marvanová S, Ciganek M, Neča J, Pěnčíková K, Mahadevan B, Topinka J, Baird WM, Kozubík A, Machala M (2011) Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons. Mutat Res 714(1–2):53–62

    PubMed  Google Scholar 

  • Baïz N, Dargent-Molina P, Wark JD, Souberbielle JC, Slama R, Annesi-Maesano I, EDEN Mother-Child Cohort Study Group (2012) Gestational exposure to urban air pollution related to a decrease in cord blood vitamin D levels. J Clin Endocrinol Metab 97(11):4087–4095

    PubMed  Google Scholar 

  • Bako G, Dewar R, Hanson J, Hill G (1984) Population density as an indicator of urban-rural differences in cancer incidence, Alberta, Canada, 1969–73. Can J Public Health 75(2):152–156

    CAS  PubMed  Google Scholar 

  • Baskurt OK, Levi E, Caglayan S, Dikmenoglu N, Kutman MN (1990) Hematological and hemorheological effects of air pollution. Arch Environ Health 45:224–228

    CAS  PubMed  Google Scholar 

  • Bilinski MJ, Thorne JG, Oh MJ, Leonard S, Murrant C, Tayade C, Croy BA (2008) Uterine NK cells in murine pregnancy. Reprod Biomed Online 16(2):218–226

    CAS  PubMed  Google Scholar 

  • Bobak M, Leon DA (1999) Pregnancy outcomes and outdoor air pollution: an ecological study in districts of the Czech Republic 1986–8. Occup Environ Med 56(8):539–543

    PubMed Central  CAS  PubMed  Google Scholar 

  • Bonner MR, Han D, Nie J, Rogerson P, Vena JE, Muti P, Trevisan M, Edge SB, Freudenheim JL (2005) Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measure. Cancer Epidemiol Biomarkers Prev 14(1):53–60

    CAS  PubMed  Google Scholar 

  • Borgeest C, Miller KP, Gupta R, Greenfeld C, Hruska KS, Hoyer P, Flaws JA (2004) Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol. Biol Reprod 70(6):1828–1835

    CAS  PubMed  Google Scholar 

  • Brot C, Jorgensen NR, Sorensen OH (1999) The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr 53:920–926

    CAS  PubMed  Google Scholar 

  • Brown JS, Zeman KL, Bennett WD (2002) Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 166(9):1240–1247

    PubMed  Google Scholar 

  • Burch WM (2002) Passage of inhaled particles into the blood circulation in humans. Circulation 106(20):141–142

    Google Scholar 

  • Castro KR, Ribeiro R, Peres M, Saldiva P, Matsuda M, Veras M (2013) Murine uterine receptivity markers are affected by particulate air pollution in a dose response manner. Placenta 34(2):A10

    Google Scholar 

  • Chen J, Tan M, Nemmar A, Song W, Dong M, Zhang G, Li Y (2006) Quantification of extrapulmonary translocation of intratracheal-instilled particles in vivo in rats: effect of lipopolysaccharide. Toxicology 222:195–201

    CAS  PubMed  Google Scholar 

  • Chen TM, Shofer S, Gokhale J, Kuschner WG (2007) Outdoor air pollution: overview and historical perspective. Am J Med Sci 333(4):230–234

    PubMed  Google Scholar 

  • Chen H, Goldberg MS, Villeneuve PJ (2008) A systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases. Rev Environ Health 23(4):243–297

    CAS  PubMed  Google Scholar 

  • Colbeck I, Lazaridis M (2010) Aerosols and environmental pollution. Naturwissenschaften 97(2):117–131

    CAS  PubMed  Google Scholar 

  • Coyle YM (2004) The effect of environment on breast cancer risk. Breast Cancer Res Treat 84(3):273–288

    CAS  PubMed  Google Scholar 

  • Crouse DL, Goldberg MS, Ross NA, Chen H, Labrèche F (2010) Postmenopausal breast cancer is associated with exposure to traffic-related air pollution in Montreal, Canada: a case-control study. Environ Health Perspect 118(11):1578–1583

    PubMed Central  PubMed  Google Scholar 

  • Davis DL, Gottlieb MB, Stampnitzky JR (1998) Reduced ratio of male to female births in several industrial countries: a sentinel health indicator? JAMA 279(13):1018–1023

    CAS  PubMed  Google Scholar 

  • De Rosa M, Zarrilli S, Paesano L, Carbone U, Boggia B, Petretta M et al (2003) Traffic pollutants affect fertility in men. Hum Reprod 18(5):1055–1061

    PubMed  Google Scholar 

  • Dejmek J, Jelinek R, Benes I, Sram RJ (1998) Impact of air pollution on human fertility: acute effects of SO2, NOx and PM. Epidemiology 9(4):148

    Google Scholar 

  • Dejmek J, Selevan SG, Benes I, Solanský I, Srám RJ (1999) Fetal growth and maternal exposure to particulate matter during pregnancy. Environ Health Perspect 107(6):475–480

    PubMed Central  CAS  PubMed  Google Scholar 

  • Dejmek J, Jelínek R, Solansky’ I, Benes I, Srám RJ (2000) Fecundability and parental exposure to ambient sulfur dioxide. Environ Health Perspect 108(7):647–654

    PubMed Central  CAS  PubMed  Google Scholar 

  • Dockery DW (2009) Health effects of particulate air pollution. Ann Epidemiol 19(4):257–263

    PubMed Central  PubMed  Google Scholar 

  • EPA (1996) Guidelines for reproductive toxicity risk assessment. http://www.epa.gov/raf/publications/pdfs/REPRO51.PDF. Accessed 15 June 2013

  • EPA (2011) Report to congress: the benefits and costs of the Clean Air Act 1990 to 2020. U.S. http://www.epa.gov/oar/sect812/feb11/fullreport_rev_a.pdf. Accessed 2 Aug 2013

  • Faiz AS, Rhoads GG, Demissie K, Lin Y, Kruse L, Rich DQ (2013) Does ambient air pollution trigger stillbirth? Epidemiol 24(4):538–544

    Google Scholar 

  • Fajersztajn L, Veras M, Barrozo LV, Saldiva P (2013) Air pollution: a potentially modifiable risk factor for lung cancer. Nat Rev Cancer 13(9):674–678

    CAS  PubMed  Google Scholar 

  • Ferin J, Oberdörster G, Penney DP (1992) Pulmonary retention of ultrafine and fine particles in rats. Am J Respir Cell Mol Biol 6(5):535–542

    CAS  PubMed  Google Scholar 

  • Gibbons AF, Chang MC (1972) Number of mast cells in the rat uterus with special reference to its relation to hormonal treatment and decidual response. Biol Reprod 6:193–203

    CAS  PubMed  Google Scholar 

  • Gilbert WM, Young AL, Danielsen B (2007) Pregnancy outcomes in women with chronic hypertension: a population-based study. J Reprod Med 52(11):1046–1051

    PubMed  Google Scholar 

  • Glinianaia SV, Rankin J, Bell R, Pless-Mulloli T, Howel D (2004) Particulate air pollution and fetal health: a systematic review of the epidemiologic evidence. Epidemiol 15:36–45

    Google Scholar 

  • Gluckman PD, Hanson MA (2004) Maternal constraint of fetal growth and its consequences. Semin Fetal Neonatal Med 9(5):419–425

    PubMed  Google Scholar 

  • Gouveia N, Bremner SA, Novaes HM (2004) Association between ambient air pollution and birth weight in São Paulo, Brazil. J Epidemiol Community Health 58(1):11–17

    PubMed Central  CAS  PubMed  Google Scholar 

  • Guven A, Kayikci A, Cam K, Arbak P, Balbay O, Cam M (2008) Alterations in semen parameters of toll collectors working at motorways: does diesel exposure induce detrimental effects on semen? Andrologia 40(6):346–351

    CAS  PubMed  Google Scholar 

  • Ha EH, Hong YC, Lee BE, Woo BH, Schwartz J, Christiani DC (2001) Is air pollution a risk factor for low birth weight in Seoul? Epidemiol 12(6):643–648

    CAS  Google Scholar 

  • Hall SA, Kaufman JS, Millikan RC, Ricketts TC, Herman D, Savitz DA (2005) Urbanization and breast cancer incidence in North Carolina, 1995–1999. Ann Epidemiol 15(10):796–803

    PubMed  Google Scholar 

  • Hammoud A, Carrell DT, Gibson M, Sanderson M, Parker-Jones K, Peterson CM (2010) Decreased sperm motility is associated with air pollution in Salt Lake City. Fertil Steril 93(6):1875–1879

    PubMed  Google Scholar 

  • Han Y, Xia Y, Zhu P, Qiao S, Zhao R, Jin N, Wang S, Song L, Fu G, Wang X (2010) Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males. Sci Total Environ 408(4):768–773

    CAS  PubMed  Google Scholar 

  • Hansen C, Neller A, Williams G, Simpson R (2006) Maternal exposure to low levels of ambient air pollution and preterm birth in Brisbane, Australia. BJOG 113(8):935–941

    CAS  PubMed  Google Scholar 

  • Hansen C, Luben TJ, Sacks JD, Olshan A, Jeffay S, Strader L, Perreault SD (2010) The effect of ambient air pollution on sperm quality. Environ Health Perspect 118(2):203–209

    PubMed Central  CAS  PubMed  Google Scholar 

  • Heal MR, Kumar P, Harrison RM (2012) Particles, air quality, policy and health. Chem Soc Rev 41:6606–6630

    CAS  PubMed  Google Scholar 

  • Helfand WH, Lazarus J, Theerman P (2001) Donora, Pennsylvania: an environmental disaster of the 20th century. Am J Public Health 91:553

    PubMed Central  CAS  PubMed  Google Scholar 

  • Herr CE, Dostal M, Ghosh R, Ashwood P, Lipsett M, Pinkerton KE, Sram R, Hertz-Picciotto I (2010) Air pollution exposure during critical time periods in gestation and alterations in cord blood lymphocyte distribution: a cohort of livebirths. Environ Health 9:46

    PubMed Central  PubMed  Google Scholar 

  • Herr CE, Ghosh R, Dostal M, Skokanova V, Ashwood P, Lipsett M, Joad JP, Pinkerton KE, Yap PS, Frost JD, Sram R, Hertz-Picciotto I (2011) Exposure to air pollution in critical prenatal time windows and IgE levels in newborns. Pediatr Allergy Immunol 22(1):75–84

    PubMed  Google Scholar 

  • Hirshfield AN (1997) Overview of ovarian follicular development: considerations for the toxicologist. Environ Mol Mutagen 29(1):10–15

    CAS  PubMed  Google Scholar 

  • Hood RD (2006) Developmental and reproductive toxicology: a practical approach, 2nd edn. CRC Press, Boca Raton

    Google Scholar 

  • Hosseinpanah F, Pour SH, Heibatollahi M, Moghbel N, Asefzade S, Azizi F (2010) The effects of air pollution on vitamin D status in healthy women: a cross sectional study. BMC Public Health 10:519

    PubMed Central  PubMed  Google Scholar 

  • Hoyer PB, Sipes IG (1996) Assessment of follicle destruction in chemical-induced ovarian toxicity. Annu Rev Pharmacol Toxicol 36:307–331

    CAS  PubMed  Google Scholar 

  • Hung LJ, Chan TF, Wu CH, Chiu HF, Yang CY (2012) Traffic air pollution and risk of death from ovarian cancer in Taiwan: fine particulate matter (PM2.5) as a proxy marker. J Toxicol Environ Health A 75(3):174–182

    CAS  PubMed  Google Scholar 

  • Huo Q, Zhang N, Wang X, Jiang L, Ma T, Yang Q (2013) Effects of ambient particulate matter on human breast cancer: is xenogenesis responsible? PLoS One 8(10):e76609. doi:10.1371/journal.pone.0076609. eCollection 2013

    PubMed Central  CAS  PubMed  Google Scholar 

  • Huynh M, Woodruff TJ, Parker JD, Schoendorf KC (2006) Relationships between air pollution and preterm birth in California. Paediatr Perinat Epidemiol 20(6):454–461

    PubMed  Google Scholar 

  • Iwai K, Mizuno S, Miyasaka Y, Mori T (2005) Correlation between suspended particles in the environmental air and causes of disease among inhabitants: cross-sectional studies using the vital statistics and air pollution data in Japan. Environ Res 99(1):106–117

    CAS  PubMed  Google Scholar 

  • Izawa H, Kohara M, Watanabe G, Taya K, Sagai M (2007) Diesel exhaust particle toxicity on spermatogenesis in the mouse is aryl hydrocarbon receptor dependent. J Reprod Dev 53(5):1069–1078

    CAS  PubMed  Google Scholar 

  • Jafarabadi M (2007) Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality. Hum Reprod 22(12):3263

    PubMed  Google Scholar 

  • Jedrychowski W, Bendkowska I, Flak E, Penar A, Jacek R, Kaim I, Spengler JD, Camann D, Perera FP (2004) Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environ Health Perspect 112(14):1398–1402

    PubMed Central  PubMed  Google Scholar 

  • Kannan S, Misra DP, Dvonch T, Krishnakumar A (2006) Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition. Environ Health Perspect 114(11):1636–1642

    PubMed Central  CAS  PubMed  Google Scholar 

  • Kannan S, Misra DP, Dvonch JT, Krishnakumar A (2007) Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential. Cien Saude Colet 12(6):1591–1602

    PubMed  Google Scholar 

  • Kelishadi R, Sharifi-Ghazvini F, Poursafa P, Mehrabian F, Farajian S, Yousefy H, Movahedian M, Sharifi-Ghazvini S (2013) Determinants of hypovitaminosis D in pregnant women and their newborns in a sunny region. Int J Endocrinol 2013:1–6

    Google Scholar 

  • Kim DH, Sabour S, Sagar UN, Adams S, Whellan DJ (2008) Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). Am J Cardiol 102:1540–1544

    CAS  PubMed  Google Scholar 

  • Knottnerus JA, Delgado LR, Knipschild PG, Essed GG, Smits F (1990) Haematologic parameters and pregnancy outcome: a prospective cohortstudy in the third trimester. J Clin Epidemiol 43:461–466

    CAS  PubMed  Google Scholar 

  • Kok TM, Driece HA, Hogervorst JG, Briedé JJ (2006) Toxicological assessment of ambient and traffic-related particulate matter: a review of recent studies. Mutat Res 613(2–3):103–122

    PubMed  Google Scholar 

  • Kristensen P, Eilertsen E, Einarsdóttir E, Haugen A, Skaug V, Ovrebø S (1995) Fertility in mice after prenatal exposure to benzo[a]pyrene and inorganic lead. Environ Health Perspect 103(6):588–590

    PubMed Central  CAS  PubMed  Google Scholar 

  • Lange NE, Litonjua A, Hawrylowicz CM, Weiss S (2009) Vitamin D, the immune system and asthma. Expert Rev Clin Immunol 5:693–702

    PubMed Central  CAS  PubMed  Google Scholar 

  • Laumbach RJ (2010) Outdoor air pollutants and patient health. Am Fam Physician 81(2):175–180

    PubMed Central  PubMed  Google Scholar 

  • Lee PC, Roberts JM, Catov JM, Talbott EO, Ritz B (2013) First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA. Matern Child Health J 17(3):545–555

    PubMed Central  PubMed  Google Scholar 

  • Leem JH, Kaplan BM, Shim YK, Pohl HR, Gotway CA, Bullard SM, Rogers JF, Smith MM, Tylenda CA (2006) Exposures to air pollutants during pregnancy and preterm delivery. Environ Health Perspect 114(6):905–910

    PubMed Central  CAS  PubMed  Google Scholar 

  • Lewis-Michl EL, Melius JM, Kallenbach LR, Ju CL, Talbot TO, Orr MF, Lauridsen PE (1996) Breast cancer risk and residence near industry or traffic in Nassau and Suffolk Counties, Long Island, New York. Arch Environ Health 51(4):255–265

    CAS  PubMed  Google Scholar 

  • Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111(4):455–460

    PubMed Central  CAS  PubMed  Google Scholar 

  • Lichtenfels AJ, Gomes JB, Pieri PC, El Khouri Miraglia SG, Hallak J, Saldiva PH (2007) Increased levels of air pollution and a decrease in the human and mouse male-to-female ratio in São Paulo, Brazil. Fertil Steril 87(1):230–232

    PubMed  Google Scholar 

  • Lloyd OL, Smith G, Lloyd MM et al (1985) Raised mortality from lung cancer and high sex ratios of births associated with industrial pollution. Br J Ind Med 42(7):475–480

    PubMed Central  CAS  PubMed  Google Scholar 

  • Logan WP (1953) Mortality in the London fog incident, 1952. Lancet 1:336–338

    CAS  PubMed  Google Scholar 

  • Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K, on behalf of the International Agency for Research on Cancer Monograph Working Group IARC, Lyon, France, on behalf of the International Agency for Research on Cancer Monograph Working Group IARC, Lyon, France (2013) The carcinogenicity of outdoor air pollution. Lancet Oncol 14(13):1262–1263

    Google Scholar 

  • Maisonet M, Bush TJ, Correa A, Jaakkola JJ (2001) Relation between ambient air pollution and low birth weight in the Northeastern United States. Environ Health Perspect 109(3):351–356

    PubMed Central  CAS  PubMed  Google Scholar 

  • Maisonet M, Correa A, Misra D, Jaakkola JJ (2004) A review of the literature on the effects of ambient air pollution on fetal growth. Environ Res 95(1):106–115

    CAS  PubMed  Google Scholar 

  • Mamatsashvili MI (1970) Detrimental effect of carbon monoxide and sulfur dioxide on fertility of female rats. Hyg Sanit 35(4–6):277–279

    Google Scholar 

  • Mannes T, Jalaludin B, Morgan G, Lincoln D, Sheppeard V, Corbett S (2005) Impact of ambient air pollution on birth weight in Sydney, Australia. Occup Environ Med 62(8):524–530

    PubMed Central  CAS  PubMed  Google Scholar 

  • Marx L, Arck P, Kieslich C, Mitterlechner S, Kapp M, Dietl J (1999) Decidual mast cells might be involved in the onset of human first-trimester abortion. Am J Reprod Immunol 41:34–40

    CAS  PubMed  Google Scholar 

  • Mattison DR, Thomford PJ (1989) The mechanisms of action of reproductive toxicants. Toxicol Pathol 17(2):364–376

    CAS  PubMed  Google Scholar 

  • McLachlan JA, Arnold SF (1996) Environmental estrogens. Am Sci 84:452–461

    Google Scholar 

  • Menzel DB (1994) The toxicity of air pollution in experimental animals and humans: the role of oxidative stress. Toxicol Lett 72(1–3):269–277

    CAS  PubMed  Google Scholar 

  • Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, de la Fuente JM, Cassee FR, Boon NA, Macnee W, Millar AM, Donaldson K, Newby DE (2006) Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am J Respir Crit Care Med 173(4):426–431

    PubMed  Google Scholar 

  • Miraglia SG, Veras MM, Amato-Lourenço LF, Rodrigues-Silva F, Saldiva PH et al (2013) Follow-up of the air pollution and the human male-to-female ratio analysis in Sao Paulo, Brazil: a times series study. BMJ Open 3(7). pii: e002552. doi:10.1136/bmjopen-2013-002552

  • Mohallem SV, de Araújo Lobo DJ, Pesquero CR, Assunção JV, de Andre PA, Saldiva PH, Dolhnikoff M (2005) Decreased fertility in mice exposed to environmental air pollution in the city of Sao Paulo. Environ Res 98(2):196–202

    CAS  PubMed  Google Scholar 

  • Möller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Häussinger K, Kreyling WG (2008) Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 177(4):426–432

    PubMed  Google Scholar 

  • Morello-Frosch R, Jesdale BM, Sadd JL, Pastor M (2010) Ambient air pollution exposure and full-term birth weight in California. Environ Health 28(9):44

    Google Scholar 

  • Need AG, Kemp A, Giles N, Morris HA, Horowitz M, Nordin BE (2002) Relationships between intestinal calcium absorption, serum vitamin metabolites and smoking in postmenopausal women. Osteoporos Int 13:83–88

    CAS  PubMed  Google Scholar 

  • O’Neill MS, Jerrett M, Kawachi I et al (2003) Health, wealth, and air pollution: advancing theory and methods. Environ Health Perspect 111:1861–1870

    PubMed Central  PubMed  Google Scholar 

  • Oberdorster G, Utell MJ (2002) Ultrafine particles in the urban air: to the respiratory tract – and beyond? Environ Health Perspect 110:440–441

    Google Scholar 

  • Olsson D, Mogren I, Forsberg B (2013) Air pollution exposure in early pregnancy and adverse pregnancy outcomes: a register-based cohort study. BMJ Open 3(2):1–8

    Google Scholar 

  • Ono Y, Takagi K, Seki H, Takai Y, Samejima K, Matsunaga S, Matsumura H (2013) Neonatal outcome in infants of chronically hypertensive mothers. J Obstet Gynaecol Res 39(6):1142–1146

    PubMed  Google Scholar 

  • Osmond C, Barker DJ (2000) Fetal, infant, and childhood growth are predictors of coronary heart disease, diabetes, and hypertension in adult men and women. Environ Health Perspect 108 Suppl 3:545–553

    CAS  PubMed  Google Scholar 

  • Parent MÉ, Goldberg MS, Crouse DL, Ross NA, Chen H, Valois MF, Liautaud A (2013) Traffic-related air pollution and prostate cancer risk: a case-control study in Montreal, Canada. Occup Environ Med 70(7):511–518

    PubMed  Google Scholar 

  • Parker JD, Woodruff TJ (2008) Influences of study design and location on the relationship between particulate matter air pollution and birthweight. Paediatr Perinat Epidemiol 22(3):214–227

    PubMed  Google Scholar 

  • Pekkanen J, Brunner EJ, Anderson HR, Tiittanen P, Atkinson RW (2000) Daily concentrations of air pollution and plasma fibrinogen in London. Occup Environ Med 57:818–822

    PubMed Central  CAS  PubMed  Google Scholar 

  • Pereira LAA, Loomis D, Conceicao GMS et al (1998) Association between air pollution and intrauterine mortality in Sao Paulo, Brazil. Environ Health Perspect 106:325–329

    PubMed Central  CAS  PubMed  Google Scholar 

  • Perin PM, Maluf M, Czeresnia CE, Januário DA, Saldiva PHN (2010a) Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET). J Assist Reprod Genet 27(7):371–382

    PubMed Central  PubMed  Google Scholar 

  • Perin PM, Maluf M, Czeresnia CE, Nicolosi Foltran Januário DA, Saldiva PHN (2010b) Effects of exposure to high levels of particulate air pollution during the follicular phase of the conception cycle on pregnancy outcome in couples undergoing in vitro fertilization and embryo transfer. Fertil Steril 93(1):301–303

    PubMed  Google Scholar 

  • Peters A, Döring A, Wichmann HE, Koenig W (1997) Increased plasma viscosity during an air pollution episode: a link to mortality? Lancet 349(9065):1582–1587

    CAS  PubMed  Google Scholar 

  • Ponce NA, Hoggatt KJ, Wilhelm M, Ritz B (2005) Preterm birth: the interaction of traffic-related air pollution with economic hardship in Los Angeles neighborhoods. Am J Epidemiol 162(2):140–148

    PubMed Central  PubMed  Google Scholar 

  • Pope CA 3rd (2000) Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who’s at risk? Environ Health Perspect 108 Suppl 4:713–723

    PubMed  Google Scholar 

  • Pope CA 3rd, Ezzati M, Dockery DW (2009) Fine-particulate air pollution and life expectancy in the United States. N Engl J Med 360(4):376–386

    PubMed Central  CAS  PubMed  Google Scholar 

  • Rahman I, MacNee W (2000) Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 16(3):534–554

    CAS  PubMed  Google Scholar 

  • Ren C, Tong S (2008) Health effects of ambient air pollution-recent research development and contemporary methodological challenges. Environ Health 7:56

    PubMed Central  PubMed  Google Scholar 

  • Reynolds P, Hurley S, Goldberg DE, Anton-Culver H, Bernstein L, Deapen D et al (2004) Regional variations in breast cancer among California teachers. Epidemiol 15(6):746–754

    Google Scholar 

  • Ritz B, Wilhelm M (2008) Ambient air pollution and adverse birth outcomes: methodologic issues in an emerging field. Basic Clin Pharmacol Toxicol 102(2):182–190

    PubMed Central  CAS  PubMed  Google Scholar 

  • Ritz B, Yu F, Chapa G, Fruin S (2000) Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiol 11(5):502–511

    CAS  Google Scholar 

  • Rocha E, Silva IR, Lichtenfels AJ, Amador Pereira LA, Saldiva PH (2008) Effects of ambient levels of air pollution generated by traffic on birth and placental weights in mice. Fertil Steril 90(5):1921–1924

    Google Scholar 

  • Rowe T (2006) Fertility and a woman’s age. J Reprod Med 51:157–163

    PubMed  Google Scholar 

  • Rubes J, Selevan SG, Evenson DP, Zudova D, Vozdova M, Zudova Z, Robbins WA, Perreault SD (2005) Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality. Hum Reprod 20(10):2776–2783

    CAS  PubMed  Google Scholar 

  • Rudel RA, Attfield KA, Schifano JN et al (2007) Chemicals causing mammary gland tumors in animals signal new directions for epidemiology, chemicals testing, and risk assessment for breast cancer prevention. Cancer 109:2635–2666

    CAS  PubMed  Google Scholar 

  • Rudra CB, Williams MA, Sheppard L, Koenig JQ, Schiff MA (2011) Ambient carbon monoxide and fine particulate matter in relation to preeclampsia and preterm delivery in western Washington State. Environ Health Perspect 119(6):886–892

    PubMed Central  CAS  PubMed  Google Scholar 

  • Sadeu JC, Hughes CL, Agarwal S, Foster WG (2010) Alcohol, drugs, caffeine, tobacco, and environmental contaminant exposure: reproductive health consequences and clinical implications. Crit Rev Toxicol 40(7):633–652

    CAS  PubMed  Google Scholar 

  • Saldiva PHN, Clarke RW, Coull BA, Stearns RC, Lawrence J, Krishna Murthy GG, Diaz E, Koutrakis P, Suh H, Tsuda A, Godleski JJ (2002) Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am J Respir Crit Care Med 165:1610–1617

    PubMed  Google Scholar 

  • Schnorr TM, Lawson CC, Whelan EA et al (2001) Spontaneous abortion, sex ratio, and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 109(11):1127–1132

    PubMed Central  CAS  PubMed  Google Scholar 

  • Schwartz J (2006) Long-term effects of exposure to particulate air pollution. Clin Occup Environ Med 5(4):837–848

    PubMed  Google Scholar 

  • Scoriza J, Saldiva PHN, Caldini EG, Veras MM (2009) Effects of pre-gestational and gestational exposure to air pollution (particulate matter) on mast cell density in implantation sites of mice. In: Abstracts of the II symposium on reproductive immunology, Rio de Janeiro, 2009

    Google Scholar 

  • Seaton A, Macnee W, Donald K, Godden D (1995) Particulate air pollution and acute health effects. Lancet 345:176–178

    CAS  PubMed  Google Scholar 

  • Selevan SG, Borkovec L, Slott VL, Zudová Z, Rubes J, Evenson DP, Perreault SD (2000) Semen quality and reproductive health of young Czech men exposed to seasonal air pollution. Environ Health Perspect 108(9):887–894

    PubMed Central  CAS  PubMed  Google Scholar 

  • Sioutas C, Delfino R, Singh M (2005) Exposure assessment for atmospheric ultrafine particles (UFPs) and implications for epidemiologic research. Environ Health Perspect 113:947–955

    PubMed Central  PubMed  Google Scholar 

  • Slama R, Darrow L, Parker J, Woodruff TJ, Strickland M, Nieuwenhuijsen M, Glinianaia S, Hoggatt KJ, Kannan S, Hurley F, Kalinka J, Srám R, Brauer M, Wilhelm M, Heinrich J, Ritz B (2008) Meeting report: atmospheric pollution and human reproduction. Environ Health Perspect 116(6):791–798

    PubMed Central  PubMed  Google Scholar 

  • Slama R, Bottagisi S, Solansky I, Lepeule J, Giorgis-Allemand L, Sram R (2013) Short-term impact of atmospheric pollution on fecundability. Epidemiology 24(6):871–879

    PubMed  Google Scholar 

  • Sokol RZ, Kraft P, Fowler IM, Mamet R, Kim E, Berhane KT (2006) Exposure to environmental ozone alters semen quality. Environ Health Perspect 114(3):360–365

    PubMed Central  CAS  PubMed  Google Scholar 

  • Soll-Johanning H, Bach E (2004) Occupational exposure to air pollution and cancer risk among Danish urban mail carriers. Int Arch Occup Environ Health 77(5):351–356

    CAS  PubMed  Google Scholar 

  • Somers CM (2011) Ambient air pollution exposure and damage to male gametes: human studies and in situ ‘sentinel’ animal experiments. Syst Biol Reprod Med 57:63–71

    CAS  PubMed  Google Scholar 

  • Somers CM, Cooper DN (2009) Air pollution and mutations in the germline: are humans at risk? Hum Genet 125(2):119–130

    CAS  PubMed  Google Scholar 

  • Somers CM, Yauk CL, White PA, Parfett CLJ, Quinn JS (2002) Air pollution induces heritable DNA mutations. Proc Natl Acad Sci 99:15904–15907

    PubMed Central  CAS  PubMed  Google Scholar 

  • Somers CM, McCarry BE, Malek F, Quinn JS (2004) Reduction of particulate air pollution lowers the risk of heritable mutations in mice. Science 304:1008–1010

    CAS  PubMed  Google Scholar 

  • Sørensen M, Daneshvar B, Hansen M, Dragsted LO, Hertel O, Knudsen L, Loft S (2003) Personal PM2.5 exposure and markers of oxidative stress in blood. Environ Health Perspect 111:161–166

    PubMed Central  PubMed  Google Scholar 

  • Squadrito GL, Cueto R, Dellinger B, Pryor WA (2001) Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter. Free Radic Biol Med 31(9):1132–1138

    CAS  PubMed  Google Scholar 

  • Srám RJ, Binková B, Dejmek J, Bobak M (2005) Ambient air pollution and pregnancy outcomes: a review of the literature. Environ Health Perspect 113(4):375–382

    PubMed Central  PubMed  Google Scholar 

  • Sriramachari S (2005) Bhopal gas tragedy: scientific challenges and lessons for future. J Loss Prev Process Ind 18(4–6):264–267

    Google Scholar 

  • Stillerman KP, Mattison DR, Giudice LC, Woodruff TJ (2008) Environmental exposures and adverse pregnancy outcomes: a review of the science. Reprod Sci 15(7):631–650

    PubMed  Google Scholar 

  • Takeda K, Tsukue N, Yoshida S (2004) Endocrine-disrupting activity of chemicals in diesel exhaust and diesel exhaust particles. Environ Sci 11(1):33–45

    CAS  PubMed  Google Scholar 

  • Takenaka S, Dornhofer-Takenaka H, Muhle H (1986) Alveolar distribution of fly ash and of titanium dioxide after long-term inhalation by Wistar rats. J Aerosol Sci 17:361–364

    Google Scholar 

  • Telisman S, Colak B, Pizent A, Jurasović J, Cvitković P (2007) Reproductive toxicity of low-level lead exposure in men. Environ Res 105(2):256–266

    CAS  PubMed  Google Scholar 

  • Terrell ML, Hartnett KP, Marcus M (2011) Can environmental or occupational hazards alter the sex ratio at birth? A systematic review. Emerg Health Threats J 4:1–18

    Google Scholar 

  • Thurston GD, Balmes JR (2012) Particulate matter and the environmental protection agency setting the right standard. Am J Respir Cell Mol Biol 47(6):727–728

    CAS  PubMed  Google Scholar 

  • Tragaki A, Lasaridi K (2009) Temporal and spatial trends in the sex ratio at birth in Greece, 1960–2006: exploring potential environmental factors. Popul Environ 30(3):114–128

    Google Scholar 

  • Tsukue N, Toda N, Tsubone H, Sagai M, Jin WZ, Watanabe G, Taya K, Birumachi J, Suzuki AK (2001) Diesel exhaust (DE) affects the regulation of testicular function in male Fischer 344 rats. J Toxicol Environ Health A 63(2):115–126

    CAS  PubMed  Google Scholar 

  • Vahlsing C, Smith KR (2012) Global review of national ambient air quality standards for PM10 and SO2 (24 h). Air Qual Atmos Health 5:393–399

    PubMed Central  CAS  PubMed  Google Scholar 

  • Valavanidis A, Fiotakis K, Vlachogianni T (2008) Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26(4):339–362

    CAS  PubMed  Google Scholar 

  • van den Hooven EH, Pierik FH, de Kluizenaar Y, Willemsen SP, Hofman A, van Ratingen SW, Zandveld PY, Mackenbach JP, Steegers EA, Miedema HM, Jaddoe VW (2012a) Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: a prospective cohort study. Environ Health Perspect 120(1):150–156

    PubMed Central  PubMed  Google Scholar 

  • van den Hooven EH, Pierik FH, Kluizenaar Y, Hofman A, van Ratingen SW, Zandveld PY, Russcher H, Lindemans J, Miedema HM, Steegers EA, Jaddoe VW (2012b) Air pollution exposure and markers of placental growth and function: the generation R study. Environ Health Perspect 120(12):1753–1759

    PubMed Central  PubMed  Google Scholar 

  • Van Erp AM, O’Keefe R, Cohen AJ, Warren J (2008) Evaluating the effectiveness of air quality interventions. J Toxicol Environ Health A 71:583–587

    PubMed  Google Scholar 

  • Veras MM, Damaceno-Rodrigues NR, Caldini EG, Maciel Ribeiro AA, Mayhew TM, Saldiva PH, Dolhnikoff M (2008) Particulate urban air pollution affects the functional morphology of mouse placenta. Biol Reprod 79:578–584

    CAS  PubMed  Google Scholar 

  • Veras MM, Damaceno-Rodrigues NR, Guimarães Silva RM, Scoriza JN, Saldiva PH, Caldini EG, Dolhnikoff M (2009) Chronic exposure to fine particulate matter emitted by traffic affects reproductive and fetal outcomes in mice. Environ Res 109(5):536–543

    CAS  PubMed  Google Scholar 

  • Veras MM, Guimarães-Silva RM, Caldini EG, Saldiva PH, Dolhnikoff M, Mayhew TM (2012) The effects of particulate ambient air pollution on the murine umbilical cord and its vessels: a quantitative morphological and immunohistochemical study. Reprod Toxicol 34(4):598–606

    CAS  PubMed  Google Scholar 

  • Vorherr H (1982) Factors influencing fetal growth. Am J Obstet Gynecol 142:577–588

    CAS  PubMed  Google Scholar 

  • Vrijheid M, Martinez D, Manzanares S, Dadvand P, Schembari A, Rankin J, Nieuwenhuijsen MJ (2011) Ambient air pollution and risk of congenital anomalies: a systematic review. Environ Health Perspect 119:598–606

    PubMed Central  CAS  PubMed  Google Scholar 

  • Wang X, Ding H, Ryan L, Xu X (1997) Association between air pollution and low birth weight: a community-based study. Environ Health Perspect 105(5):514–520

    PubMed Central  CAS  PubMed  Google Scholar 

  • Wenger D, Gerecke AC, Heeb NV, Schmid P, Hueglin C, Naegeli H, Zenobi R (2009) In vitro estrogenicity of ambient particulate matter: contribution of hydroxylated polycyclic aromatic hydrocarbons. J Appl Toxicol 29(3):223–232

    CAS  PubMed  Google Scholar 

  • WHO (2005) Air quality guidelines – global update 2005. http://www.euro.who.int/__data/assets/pdf_file/0005/78638/E90038.pdf. Accessed 10 July 2013

  • Wiebert P, Sanchez-Crespo A, Falk R, Philipson K, Lundin A, Larsson S, Möller W, Kreyling WG, Svartengren M (2006a) No significant translocation of inhaled 35-nm carbon particles to the circulation in humans. Inhal Toxicol 18(10):741–747

    Google Scholar 

  • Wiebert P, Sanchez-Crespo A, Seitz J, Falk R, Philipson K, Kreyling WG, Möller W, Sommerer K, Larsson S, Svartengren M (2006b) Negligible clearance of ultrafine particles retained in healthy and affected human lungs. Eur Respir J 28(2):286–290

    CAS  PubMed  Google Scholar 

  • Wilhelm M, Ritz B (2003) Residential proximity to traffic and adverse birth outcomes in Los Angeles county, California, 1994–1996. Environ Health Perspect 111(2):207–216

    PubMed Central  PubMed  Google Scholar 

  • Williams FL, Lawson AB, Lloyd OL (1992) Low sex ratios of births in areas at risk from air pollution from incinerators, as shown by geographical analysis and 3-dimensional mapping. Int J Epidemiol 21(2):311–319

    CAS  PubMed  Google Scholar 

  • Woodruff TK, Walker CL (2008) Fetal and early postnatal environmental exposures and reproductive health effects in the female. Fertil Steril 89:47–51

    Google Scholar 

  • Woodruff TJ, Parker JD, Kyle AD, Schoendorf KC (2003) Disparities in exposure to air pollution during pregnancy. Environ Health Perspect 111(7):942–946

    PubMed Central  PubMed  Google Scholar 

  • Woodruff TJ, Carlson A, Schwartz JM, Giudice LC (2008) Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary. Fertil Steril 89(2 Suppl):e1–e20

    PubMed  Google Scholar 

  • World Bank (2013a) Fertility rate (total births per women). http://data.worldbank.org/indicator/SP.DYN.TFRT.IN. Accessed 15 July 2013.

  • World Bank (2013b) PM10, country level (micrograms per cubic meter). http://data.worldbank.org/indicator/EN.ATM.PM10.MC.M3. Accessed 15 July 2013.

  • Wu J, Ren C, Delfino RJ, Chung J, Wilhelm M, Ritz B (2009) Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California. Environ Health Perspect 117(11):1773–1779

    PubMed Central  CAS  PubMed  Google Scholar 

  • Yang CY, Chang CC, Chuang HY, Ho CK, Wu TN, Tsai SS (2003) Evidence for increased risks of preterm delivery in a population residing near a freeway in Taiwan. Arch Environ Health 58(10):649–654

    CAS  PubMed  Google Scholar 

  • Yauk CL, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ et al (2008) Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc Natl Acad Sci 105:605–610

    PubMed Central  CAS  PubMed  Google Scholar 

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Veras, M.M., de Souza Xavier Costa, N., Fajersztajn, L., Saldiva, P.H.N. (2015). Impacts of Air Pollution on Reproductive Health. In: Nadadur, S., Hollingsworth, J. (eds) Air Pollution and Health Effects. Molecular and Integrative Toxicology. Springer, London. https://doi.org/10.1007/978-1-4471-6669-6_2

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