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Patent Foramen Ovale (PFO)

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Comprehensive Approach to Adult Congenital Heart Disease

Abstract

A patent foramen ovale (PFO) is an anatomical communication between two atria with a possibility for right-to-left shunt. PFO is a flap-like opening between the atrial septa primum and secundum at the site of the fossa ovalis that persists after 1 year of age. In utero, the foramen ovale helps as a physiologic conduit for right-to-left shunting. After birth, once the pulmonary circulation is established, left atrial (LA) pressure increases, permitting functional closure of the foramen ovale. This is followed by an anatomical closure by the age of 1 year [1, 2].

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References

  1. Kerut EK, Norfleet WT, Plotnick GD, et al. Patent foramen ovale: a review of associated conditions and the impact of physiological size. J Am Coll Cardiol. 2001;38(3):613–23.

    Article  CAS  PubMed  Google Scholar 

  2. Aslam F, Shirani J, Haque AA. Patent foramen ovale: assessment, clinical significance and therapeutic options. South Med J. 2006;99(12):1367–72.

    Article  PubMed  Google Scholar 

  3. Thaler DE, Ruthazer R, Di Angelantonio E, et al. Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale. Stroke. 2013;44(3):675–80.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Agostoni P, Gasparini G, Destro G. Acute myocardial infarction probably caused by paradoxical embolus in a pregnant woman. Heart. 2004;90(3):e12.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Sievert H, Taaffe M. Patent foramen ovale: the jury is still out. Eur Heart J. 2004;25(5):361–2.

    Article  PubMed  Google Scholar 

  6. Maffe S, Dellavesa P, Zenone F, et al. Transthoracic second harmonic two- and three-dimensional echocardiography for detection of patent foramen ovale. J Am Coll Cardiol Intv. 2010;3(9):968–73.

    Google Scholar 

  7. Shanks M, Manawadu D, Vonder Muhll I, Khan K, Becher H, Choy J. Detection of patent foramen ovale by 3D echocardiography. JACC Cardiovasc Imaging. 2012;5(3):329–31.

    Article  PubMed  Google Scholar 

  8. Danzi GB, Sesana M, Capuano C, et al. Percutaneous closure of patent foramen ovale: pathophysiology, indications, and technique. Neurol Sci. 2003;24 Suppl 1:S17–9.

    Article  PubMed  Google Scholar 

  9. Meier B, Lock JE. Contemporary management of patent foramen ovale. Circulation. 2003;107(1):5–9.

    Article  PubMed  Google Scholar 

  10. Khositseth A, Cabalka AK, Sweeney JP, Fortuin FD, Reeder GS, Connolly HM, et al. Transcatheter Amplatzer device closure of atrial septal defect and patent foramen ovale in patients with presumed paradoxical embolism. Mayo Clin Proc. 2004;79(1):35–41.

    Article  PubMed  Google Scholar 

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Correspondence to Azin Alizadehasl MD, FACC .

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Electronic Supplementary Material

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PFO in transesophageal echocardiography by 2D study in the middle area of the inter-atrial septum (MPG 4856 kb)

PFO in transesophageal echocardiography by color flow imaging (MPG 978 kb)

Agitated-saline injection into an ante-cubital vein showing many bubble passage from interatrial septum within three cardiac cycles of their appearance in the RA suggestive of PFO (MPG 4688 kb)

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© 2014 Springer-Verlag London

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Alizadehasl, A., Sadeghpour, A. (2014). Patent Foramen Ovale (PFO). In: Sadeghpour, A., Kyavar, M., Alizadehasl, A. (eds) Comprehensive Approach to Adult Congenital Heart Disease. Springer, London. https://doi.org/10.1007/978-1-4471-6383-1_54

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  • DOI: https://doi.org/10.1007/978-1-4471-6383-1_54

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6382-4

  • Online ISBN: 978-1-4471-6383-1

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