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Membranoproliferative Glomerulonephritis and C3 Glomerulopathy

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Practical Nephrology

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Abstract

The terms membranoproliferative glomerulonephritis (MPGN) and mesangiocapillary glomerulonephritis (MCGN) are interchangeable and refer to the light microscopic appearances of cellular proliferation in the mesangial regions of the glomeruli, with expansion of both cells and mesangial matrix, accompanied by thickening of the glomerular capillary walls. Rather than being a specific disease, MPGN is a morphological pattern which is associated with a wide range of distinct (and usually systemic) diseases. Recent developments in the understanding of these conditions emphasise the importance of establishing underlying disorder.

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Notes

  1. 1.

    Complement haemolytic activity: patient serum across a range of dilutions is used to lyse antibody-coated sheep erythrocytes. Lack of haemolysis at a given dilution suggests deficiency of complement component(s).

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  • Sethi S, Fervenza FC. Membranoproliferative glomerulonephritis: pathogenetic heterogeneity and proposal for a new classification. Semin Nephrol. 2011;31(4):341–8.

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  • Pickering M, Cook HT. Complement and glomerular disease: new insights. Curr Opin Nephrol Hypertens. 2011;20(3):271–7.

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Author information

Authors and Affiliations

  1. UCL Centre for Nephrology, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK

    Daniel P. Gale MA, MBBChir, MRCP(UK) PhD

  2. Histopathology Department, Betsi Cadwaladar University Health Board, Croesnewydd Road, Wrexham, LL13 7TD, UK

    Mared Owen-Casey MBBCh, FRCPath

Authors
  1. Daniel P. Gale MA, MBBChir, MRCP(UK) PhD
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  2. Mared Owen-Casey MBBCh, FRCPath
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Corresponding author

Correspondence to Daniel P. Gale MA, MBBChir, MRCP(UK) PhD .

Editor information

Editors and Affiliations

  1. UCL Department of Nephrology, Royal Free London NHS Foundation Trust, London, United Kingdom

    Mark Harber

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© 2014 Springer-Verlag London

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Gale, D.P., Owen-Casey, M. (2014). Membranoproliferative Glomerulonephritis and C3 Glomerulopathy. In: Harber, M. (eds) Practical Nephrology. Springer, London. https://doi.org/10.1007/978-1-4471-5547-8_18

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  • DOI: https://doi.org/10.1007/978-1-4471-5547-8_18

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-5546-1

  • Online ISBN: 978-1-4471-5547-8

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