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Vincristine Local Delivery for Renal Artery Denervation

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Renal Denervation

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Abstract

The contribution of renal sympathetic nerve activity to the development and progression of resistant hypertension, has been convincingly demonstrated in both preclinical and human experiments. Preclinical experiments in hypertension models of hypertension [5, 6, 14], have successfully used renal denervation as both an experimental tool and a therapeutic strategy, but even earlier, in the absence of appropriate drugs to pharmacologically reduce blood pressure in severely hypertensive patients, therapeutic splanchnicectomy and even radical surgical sympathectomy were used since the 1930s. These surgical techniques have been abandoned due to their severe side effects. Recent studies have further investigated the close relationship between kidneys and brain, and gave light to some important parameters of this transaction. Low frequency stimulation of the sympathetic system resulted in renin excretion only, intermediate frequency stimulation results on decreased urinary sodium excretion and high frequency stimulation, results on direct renal artery vasoconstriction, decrease in renal blood flow and decrease glomerular filtration rate [2, 5, 10].

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References

  1. Arndt C, Tefft M, Gehan E, Anderson J, Jenson M, Link M, Donaldson S, Breneman J, Wiener E, Webber B, Maurer H. A feasibility, toxicity, and early response study of etoposide, ifosfamide, and vincristine for the treatment of children with rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study (IRS) IV pilot study. J Pediatr Hematol Oncol. 1997;19(2):124–9.

    Article  CAS  PubMed  Google Scholar 

  2. Barajas L, Muller J. The innervation of the juxtaglomerular apparatus and surrounding tubules: a quantitative analysis by serial section electron microscopy. J Ultrastruct Res. 1973;43(1):107–32.

    Article  CAS  PubMed  Google Scholar 

  3. Carbone PP, Bono V, Frei 3rd E, Brindley CO. Clinical studies with vincristine. Blood. 1963;21:640–7.

    CAS  PubMed  Google Scholar 

  4. Consigny PM, Davalian D, Donn R, Hu J, Rieser M, Stolarik D. Chemical renal denervation in the rat. Cardiovasc Intervent Radiol. 2013;37(1):218–23.

    Article  PubMed  Google Scholar 

  5. DiBona GF. The sympathetic nervous system and hypertension: recent developments. Hypertension. 2004;43(2):147–50.

    Article  CAS  PubMed  Google Scholar 

  6. Doumas M, Papademetriou V, Douma S, Faselis C, Tsioufis K, Gkaliagkousi E, Petidis K, Zamboulis C. Benefits from treatment and control of patients with resistant hypertension. Int J Hypertens. 2010;2011:318549.

    Google Scholar 

  7. Earl HM, Connolly S, Latoufis C, Eagle K, Ash CM, Fowler C, Souhami RL. Long-term neurotoxicity of chemotherapy in adolescents and young adults treated for bone and soft tissue sarcomas. Sarcoma. 1998;2:97–105.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Egbelakin A, Ferguson MJ, MacGill EA, Lehmann AS, Topletz AR, Quinney SK, Li L, McCammack KC, Hall SD, Renbarger JL. Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011;56(3):361–7.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2011;9756:1903–9.

    Google Scholar 

  10. Gewirtz JR, Bisognano JD. Catheter-based renal sympathetic denervation: a targeted approach to resistant hypertension. Cardiol J. 2011;1:97–102.

    Google Scholar 

  11. Holland JF, Scharlau C, Gailani S, Krant MJ, Olson KB, Horton J, Shnider BI, Lynch JJ, Owens A, Carbone PP, Colsky J, Grob D, Miller SP, Hall TC. Vincristine treatment of advanced cancer: a cooperative study of 392 cases. Cancer Res. 1973;33(6):1258–64.

    CAS  PubMed  Google Scholar 

  12. Ja'afer FM, Hamdan FB, Mohammed FH. Vincristine-induced neuropathy in rat: electrophysiological and histological study. Exp Brain Res. 2006;173(2):334–45.

    Article  PubMed  Google Scholar 

  13. Kaltenbach B, Id D, Franke JC, Sievert H, Hennersdorf M, Maier J, Bertog SC. Renal artery stenosis after renal sympathetic denervation. J Am Coll Cardiol. 2012;60(25):2694–5.

    Article  PubMed  Google Scholar 

  14. Kato T, Kassab S, Wilkins Jr FC, Kirchner KA, Granger JP. Decreased sensitivity to renal interstitial hydrostatic pressure in Dahl salt-sensitive rats. Hypertension. 1994;23(6 Pt 2):1082–6.

    Article  CAS  PubMed  Google Scholar 

  15. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;9671:1275–81.

    Article  Google Scholar 

  16. LeQuesne. Neuropathy due to drugs; diseases of the peripheral nervous system. Peripheral neuropathy. 2nd ed. Philadelphia: WB Saunders Co; 1984. p. 2173–4.

    Google Scholar 

  17. Mabin T, Sapoval M, Cabane V, Stemmett J, Iyer M. First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension. Eur Interv. 2012;​8(1):57–61.

    Google Scholar 

  18. Manning PT, Powers CW, Schmidt RE, Johnson Jr EM. Guanethidine-induced destruction of peripheral sympathetic neurons occurs by an immune-mediated mechanism. J Neurosci. 1983;3(4):714–24.

    CAS  PubMed  Google Scholar 

  19. Mantadakis E, Amoiridis G, Kondi A, Kalmanti M. Possible increase of the neurotoxicity of vincristine by the concurrent use of posaconazole in a young adult with leukemia. J Pediatr Hematol Oncol. 2007;29(2):130.

    Article  PubMed  Google Scholar 

  20. Medtronic pr (2014) http://newsroom.medtronic.com/phoenix.zhtml?c=251324&p=irol-newsArticle&ID=1889335&highlight=.

  21. Moore AS, Norris R, Price G, Nguyen T, Ni M, George R, van Breda K, Duley J, Charles B, Pinkerton RV. Vincristine pharmacodynamics and pharmacogenetics in children with cancer: a limited-sampling, population modelling approach. J Paediatr Child Health.

    Google Scholar 

  22. Pal PK. Clinical and electrophysiological studies in vincristine induced neuropathy. Electromyogr Clin Neurophysiol. 1999;39(6):323–30.

    CAS  PubMed  Google Scholar 

  23. Rosenthal S, Kaufman S. Vincristine neurotoxicity. Ann Intern Med. 1974;80(6):733–7.

    Article  CAS  PubMed  Google Scholar 

  24. Stefanadis C. Renal denervation in resistant hypertension: radiofrequency ablation and chemical denervation. Hellenic J Cardiol. 2011;52(6):481–2.

    PubMed  Google Scholar 

  25. Stefanadis C, Synetos A, Toutouzas K, Tsioufis C, Drakopoulou M, Tsiamis E, Agrogiannis G, Patsouris E, Tousoulis D. Barodenervation of the sympathetic nervous system of the renal artery. A new concept. Int J Cardiol. 2013;168(4):4443–4.

    Article  PubMed  Google Scholar 

  26. Stefanadis C, Synetos A, Toutouzas K, Tsioufis C, Drakopoulou M, Tsiamis E, Agrogiannis G, Patsouris E, Tousoulis D. New double balloon delivery catheter for chemical denervation of the renal artery with vincristine. Int J Cardiol. 2013;168(4):4346–8.

    Article  PubMed  Google Scholar 

  27. Stefanadis C, Toutouzas K, Synetos A, Tsioufis C, Karanasos A, Agrogiannis G, Stefanis L, Patsouris E, Tousoulis D. Chemical denervation of the renal artery by vincristine in swine. A new catheter based technique. Int J Cardiol. 2013;167(2):421–5.

    Google Scholar 

  28. Stefanadis C, Toutouzas K, Synetos A, Tsioufis C, Karanasos A, Agrogiannis G, Stefanis L, Patsouris E, Tousoulis D. Effectiveness of the denervation of the renal sympathetic nervous system by vincristine, by a constant flow rate delivery catheter. Int J Cardiol Subm. 2014.

    Google Scholar 

  29. Stefanadis C, Toutouzas K, Vlachopoulos C, Tsioufis C, Synetos A, Pietri P, Tousoulis D, Tsiamis E. Chemical denervation of the renal artery with vincristine for the treatment of resistant arterial hypertension: first-in-man application. Hellenic J Cardiol. 2013;54(4):318–21.

    PubMed  Google Scholar 

  30. Verstappen CC, Koeppen S, Heimans JJ, Huijgens PC, Scheulen ME, Strumberg D, Kiburg B, Postma TJ. Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening. Neurology. 2005;64(6):1076–7.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. First Department of Cardiology, Athens Medical School, Hippokration Hospital, Vas. Sofias 114, Athens, Greece

    Konstantinos Toutouzas MD, FESC, FACC, Andreas Synetos MD, FESC & Christodoulos Stefanadis MD, FESC, FACC

Authors
  1. Konstantinos Toutouzas MD, FESC, FACC
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  2. Andreas Synetos MD, FESC
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  3. Christodoulos Stefanadis MD, FESC, FACC
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Corresponding author

Correspondence to Konstantinos Toutouzas MD, FESC, FACC .

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Editors and Affiliations

  1. St. Luke's Medical Center, Phoenix, Arizona, USA

    Richard R. Heuser

  2. Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

    Markus Schlaich

  3. CardioVascular Center Frankfurt Sankt Katharinen, Frankfurt, Germany

    Horst Sievert

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Toutouzas, K., Synetos, A., Stefanadis, C. (2015). Vincristine Local Delivery for Renal Artery Denervation. In: Heuser, R., Schlaich, M., Sievert, H. (eds) Renal Denervation. Springer, London. https://doi.org/10.1007/978-1-4471-5223-1_14

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  • DOI: https://doi.org/10.1007/978-1-4471-5223-1_14

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  • Print ISBN: 978-1-4471-5222-4

  • Online ISBN: 978-1-4471-5223-1

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