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Arterial Changes in Renal Transplantation

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Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

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Abstract

Renal transplantation is the best renal replacement modality for patients with end-stage renal disease in terms of patient survival and quality of life. Despite substantial improvement in recipient outcome, stiffness of the large arterial system and cardiovascular (CV) mortality remain high compared to age- and sex-matched subjects in the general population. In addition to traditional CV risk factors, transplantation-specific parameters emerge and are related to immune interactions, drug specifications, and donor characteristics. Some of these parameters appear to be modulators of risk factors and graft and recipient outcome. Acute rejection, for example, appears as a major and independent determinant of high arterial stiffness in recipients of kidney grafts. Furthermore, past history of CV events, low graft filtration function, and donor age determine long-term patient and graft outcome. Living kidney donors, on the other hand, are normally protected especially that they are carefully selected prior to transplantation. Despite a similar long-term outcome compared to the general population, donors may be at higher risk for stiffening of the large arterial system, especially if they cluster with time, CV comorbidities.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, University Medical Center – Rizk Hospital, May Zahhar Street, Ashrafieh, Beirut, 11-3288, Lebanon

    Sola Aoun Bahous MD, PhD

  2. Department of Medicine, Gilbert and Rose Marie Chagoury School of Medicine, University Medical Center – Rizk Hospital, May Zahhar Str., Ashafieh, Beirut, 11-3288, Lebanon

    Serge Korjian MSc & Yazan Daaboul MSc

  3. Department of Medicine, Paris Descartes University, Assistance Publique des Hôpitaux de Paris, Hôtel-Dieu Hospital, Diagnosis and Therapeutics Center, 1 Place du Parvis Notre- Dame, 75004, Paris, France

    Jacques Blacher MD, PhD & Michel E. Safar MD

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  1. Sola Aoun Bahous MD, PhD
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  2. Serge Korjian MSc
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  3. Yazan Daaboul MSc
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  4. Jacques Blacher MD, PhD
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  5. Michel E. Safar MD
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Correspondence to Sola Aoun Bahous MD, PhD .

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Editors and Affiliations

  1. Hôtel-Dieu Hospital Diagnosis and Therapeutics Center, Paris Descartes University, Paris, Paris, France

    Michel E. Safar

  2. St Vincent Clinic and Hospital, University of New South Wales, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia

    Michael F. O'Rourke

  3. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

    Edward D. Frohlich

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Bahous, S.A., Korjian, S., Daaboul, Y., Blacher, J., Safar, M.E. (2014). Arterial Changes in Renal Transplantation. In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_28

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  • DOI: https://doi.org/10.1007/978-1-4471-5198-2_28

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