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Transplantation of Human Fetal Liver Cells into Children or Human Fetuses

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Human Fetal Tissue Transplantation

Abstract

Because of the natural lack of T cells during the early phases of ontogeny, fetal liver stem cells can reconstitute the hemopoietic and lymphopoietic systems of experimental animals and humans without producing severe GVHD, even in cases of full donor-host incompatibility. From the transplanted stem cells, the various cell lineages develop progressively and uneventfully. Many patients can thus be fully cured of their congenital and severe immunodeficiency, or they can have some beneficial effect on their inborn error of matabolism. Since 1988, we have also initiated the first in utero treatment, in human fetuses with various diseases, using a similar mode of fetal liver transplantation. This prenatal cell therapy has been demonstrated to be feasibel and effective in the human fetus, when performed during the early stages of fetal development and immeadiatly after prenatal diagnosis.

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Authors and Affiliations

  1. Department of Transplantation and Clinical Immunology, Claude Bernard University, Pavillon P, Hôpital E. Herriot, Lyon, 69437, France

    Jean-Louis Touraine M.D., Ph.D.

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  1. Jean-Louis Touraine M.D., Ph.D.
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Correspondence to Jean-Louis Touraine M.D., Ph.D. .

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Editors and Affiliations

  1. Southend Park 55, Kolkata, 700029, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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Touraine, JL. (2013). Transplantation of Human Fetal Liver Cells into Children or Human Fetuses. In: Bhattacharya, N., Stubblefield, P. (eds) Human Fetal Tissue Transplantation. Springer, London. https://doi.org/10.1007/978-1-4471-4171-6_16

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  • DOI: https://doi.org/10.1007/978-1-4471-4171-6_16

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4170-9

  • Online ISBN: 978-1-4471-4171-6

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