Abstract
Transcranial Doppler (TCD) provides visible and audible real-time feedback during carotid stent procedures as otherwise clinically silent small embolic particles reflect microembolic signals (MESs) during their egress from the extracranial carotid artery lesion through the middle cerebral artery en route to the ipsilateral hemisphere. During the formative years of carotid stenting, TCD was an important tool for many pioneers in the field as high-risk anatomic carotid access and lesion characteristics were being defined. In addition, TCD helped us understand the flow dynamics related to distal and proximal occlusive embolic protection platforms. Also, the disturbing storm of microembolic signals (MESs) at different stages during distal filter protection led to optimization of these system designs and procedural technique. One cannot argue the contribution TCD made to the art and science of carotid stenting through amplifying the embolization signal from the devastating clinical event of stroke seen in less than 10% of patients to the silent smaller microembolic signals ubiquitous to every procedure. While the MES data seems to have more of an academic value, the contemporary CAS program should have access to TCD and consider following peri-procedural MCA flow patterns during stenting with proximal flow reversal or flow arrest protection systems. In addition, TCD provides significant insight into the physiology of reperfusion syndrome, and changes in MCA flow velocities in patients at high risk for reperfusion syndrome in the early postprocedure time period may be helpful. The objective of this monograph is to expose the reader to some of the lessons learned from adjuvant transcranial Doppler during carotid stent-supported angioplasty while also providing insight into current clinically relevant applications.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg. 1982;57(6):769–74.
Bogdahn U, Becker G, Winkler J, et al. Transcranial color-coded real-time sonography in adults. Stroke. 1990;21:1680–8.
North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–53.
European Carotid Surgery Trialists’ Group. MRC European carotid surgery trial: interim results for symptomatic patients with severe or with mild carotid stenosis. Lancet. 1991;337:1235–43.
AbuRahma AF, Hannay RS. A study of 510 carotid endarterectomies and a review of the recent carotid endarterectomy trials. W V Med J. 2001;97(4):197–200.
Bond R, Rerkasem K, AbuRahma AF, Naylor AR, Rothwell PM. Patch angioplasty versus primary closure for carotid endarterectomy. Cochrane Database Syst Rev. 2004;(2):CD000160.
Diethrich EB. Indications for carotid artery stenting: a preview of the potential derived from early clinical experience. J Endovasc Surg. 1996;3:132–9.
Naylor AR, Bolia A, Abbott RJ, Pye IF, Smith J, Lennard N, Lloyd AJ, London NJ, Bell PR. Randomized study of carotid angioplasty and stenting versus carotid endarterectomy: a stopped trial. J Vasc Surg. 1998;28(2):326.
Leisch F, Kerschner K, Hofman R, Bibl D, Engleder C, Bergmann H. Carotid stenting: acute results and complications. Z Kardiol. 1999;88:661–8.
Bettman MA, Katzen BT, Whisnant J, Brant-Zawadski MB, Broderick JP, Furlan AJ, Hershey LA, Howard V, Kuntz R, Loftus CM, Pearce W, Roberts A, Roubin G. Carotid stenting and angioplasty. A statement for healthcare professionals from the councils on cardiovascular radiology, stroke, cardio-thoracic and vascular surgery, epidemiology and prevention, and clinical cardiology, American Heart Association. Stroke. 1998;29:336–48.
Theron JG, Peyelle GG, Coskun O, et al. Carotid artery stenosis: treatment with protected balloon angioplasty and stent placement. Radiology. 1996;201:627–36.
Wholey MH, Al-Mubarak N, Wholey MH. Updated review of the global carotid artery stent registry. Catheter Cardiovasc Interv. 2003;60:259–66.
Ohki T, Veith FJ. Carotid artery stenting: utility of cerebral protection devices. J Invasive Cardiol. 2001;13:47–55.
Henry M, Amor M, Klonaris C, et al. Angioplasty and stenting of the extracranial carotid arteries. Tex Heart Inst J. 2000;27:150–8.
Reimers B, Corvaja N, Moshiri S, et al. Cerebral protection with filter devices during carotid artery stenting. Circulation. 2001;104:12–5.
Parodi JC, Mura RL, Ferreira LM, et al. Initial evaluation of carotid angioplasty and stenting with three different cerebral protection devices. J Vasc Surg. 2000;32:1127–36.
Al-Mubarak N, Colombo A, Gaines PA, et al. Multicenter evaluation of carotid artery stenting with a filter protection system. J Am Coll Cardiol. 2002;39:841–6.
Mathur A, Roubin GS, Iyer SS, et al. Predictors of stroke complicating carotid artery stenting. Circulation. 1998;97:1239–45.
Yadav JS, Roubin GS, Iyer S, et al. Elective stenting of the extracranial carotid arteries. Circulation. 1997;95:376–81.
Al-Moubarak N, Roubin GS, Vitek JJ, et al. Effect of the distal-balloon protection system on microembolization during carotid stenting. Circulation. 2001;104:199–2002.
Mantese VA, Timaran CH, Chiu D, Begg RJ, Brott TG, CREST Investigators. The carotid revascularization endarterectomy versus stenting trial (CREST): stenting versus carotid endarterectomy for carotid disease. Stroke. 2010;41(10 Suppl):S31–4.
Zarins CK. Carotid endarterectomy: the gold standard. J Endovasc Surg. 1996;3:10–5.
Yadav JS, Wholey MH, Kuntz RE, Fayed P, Katzen BT, Mishkel GJ, Bajwa TK, Whitlow P, Strickman NE, Jaff MR, Popma JJ, Snead DB, Cutlilp DE, Firth BG, Ouriel K. Stenting and angioplasty with protection in patients at high risk for Endarterectomy Investigators. N Engl J Med. 2004;351(15):1493–501.
Ireland JK, Chaloupka JC, Weigele JB, et al. Potential utility of carotid stent assisted percutaneous transluminal angioplasty in the treatment of symptomatic carotid occlusive disease in patients with high neurological risk. Stroke. 2003;34:308.
Qureshi AI, Boulos AS, Kim SH, et al. Carotid angioplasty and stent placement using the FilterWire for distal protection: an international multicenter study. Stroke. 2003;34:307.
Roubin GS, New G, Iyer SS, et al. Immediate and late clinical outcomes of carotid artery stenting in patients with symptomatic and asymptomatic carotid artery stenosis: a 5-year prospective analysis. Circulation. 2001;103:532–7.
MacDonald S, Venables GS, Cleveland TJ, et al. Protected carotid stenting: safety and efficacy of the MedNova NeuroShield filter. J Vasc Surg. 2002;35:966–72.
Benichou H, Bergeron P. Carotid angioplasty and stenting: will periprocedural transcranial Doppler monitoring be important? J Endovasc Surg. 1996;3:217–23.
Hartmann A, Mast H, Thompson JL, Sia RM, Mohr JP. Transcranial Doppler waveform blunting in severe extracranial carotid artery stenosis. Cerebrovasc Dis. 2000;10(1):33–8.
Gomez CR, Brass LM, Tegeler CH, et al. The transcranial Doppler standardization project. J Neuroimaging. 1993;3:190–2.
Visser GH, Wieneke GH, van Huffelen AC, Eikelboom BC. The use of preoperative transcranial Doppler variables to predict which patients do not need a shunt during carotid endarterectomy. Stroke. 2003;34:813–9.
Reinhard M, Muller T, Roth M, Guschlbauer B, Timmer J, Hetzel A. Bilateral severe carotid artery stenosis or occlusion – cerebral autoregulation dynamics and collateral flow patterns. Acta Neurochir (Wien). 2003;145(12):1053–9.
Niesen WD, Rosenkranz M, Eckert B, Meissner M, Weiller C, Sliwka U. Hemodynamic changes of the cerebral circulation after stent-protected carotid angioplasty. AJNR Am J Neuroradiol. 2004;25(7):1162–7.
Mori T, Fukuoka M, Kazita K, Mima T, Mori K. Intraventricular hemorrhage after carotid stenting. J Endovasc Surg. 1999;6(4):337–41.
Sfyroeras GS, Karkos CD, Arsos G, Liasidis C, Dimitriadis AS, Papazoglou KO, Gerassimidis TS. Cerebral hyperperfusion after carotid stenting: a transcranial Doppler and SPECT study. Vasc Endovascular Surg. 2009;43(2):150–6. Epub 2008 Sep 30.
Tan W, Bates MC, Wholey M. Cerebral protection systems for distal emboli during carotid artery interventions. J Interv Cardiol. 2001;14(4):465–74.
Al-Mubarak N, Roubin GS, Vitek JJ, Iyer SS. Microembolization during carotid artery stenting with the distal-balloon antiemboli system. Int Angiol. 2002;21(4):344–8.
Parodi JC, Bates MC. Angioplasty and stent with reversal of internal carotid flow as a cerebral protection device. In: Greenhalgh RM, editor. ATLAS: vascular and endovascular surgical techniques. 4th ed. London: W.B. Saunders; 2001. p. 198–213.
Gossetti B, Gattuso R, Irace L, Faccenna F, Venosi S, Bozzao L, Fiorelli M, Andreoli R, Gossetti C. Embolism to the brain during carotid stenting and surgery. Acta Chir Belg. 2007;107(2):151–4.
Kindel M, Spiller P. Transient occlusion of an angioguard protection system by massive embolization during angioplasty of a degenerated coronary saphenous vein graft. Catheter Cardiovasc Interv. 2002;55:2501–4.
Moehring MA, Ritcey JA. Microembolus sizing in a blood mimicking fluid using a novel dual-frequency pulsed Doppler. Echocardiography. 1996;13(5):567–71.
Moehring MA, Ritcey JA. Sizing emboli in blood using pulse Doppler ultrasound – II: effects of beam refraction. IEEE Trans Biomed Eng. 1996;43(6):581–8.
Moehring MA, Klepper JR. Pulse Doppler ultrasound detection, characterization and size estimation of emboli in flowing blood. IEEE Trans Biomed Eng. 1994;41(1):35–44.
Crawley F, et al. Comparison of hemodynamic cerebral ischemia and microembolic signals detected during carotid endarterectomy and carotid angioplasty. Stroke. 1997;28(12):2460–4.
Devuyst G, Darbellay GA, Vesin JM, Kemeny V, Ritter M, Droste DW, Molina C, Serena J, Sztajzel R, Ruchat P, Lucchesi C, Dietler G, Ringelstein EB, Despland PA, Bogousslavsky J. Automatic classification of HITS into artifacts or solid or gaseous emboli by a wavelet representation combined with dual-gate TCD. Stroke. 2001;32(12):2803–9.
Georgiadis D, Uhlmann F, Lindner A, Zierz S. Differentiation between true microembolic signals and artifacts using an arbitrary sample volume. Ultrasound Med Biol. 2000;26(3):493–6.
Rodriguez RA, Giachino A, Hosking M, Nathan HJ. Transcranial Doppler characteristics of different embolic materials during in vivo testing. J Neuroimaging. 2002;12(3):259–66.
Ohki T, Roubin GS, Veith FJm, et al. The efficacy of a filter in preventing embolic events during carotid artery stenting. An ex-vivo analysis. J Vasc Surg. 1999;30:1034–44.
Coggia M, Goeau-Brissonniere O, Duval JL, et al. Embolic risk of the different stages of carotid bifurcation balloon angioplasty: an experimental study. J Vasc Surg. 2000;31:550–7.
Antonius Carotid Endarterectomy, Angioplasty, and Stenting Study Group. Transcranial Doppler monitoring in angioplasty and stenting of the carotid bifurcation. J Endovasc Ther. 2003;10(4):702–10.
Orlandi G, Fanucchi S, Fioretti C, Acerbi G, Puglioli M, Padolecchia R, Sartucci F, Murri L. Characteristics of cerebral microembolism Âduring carotid stenting and angioplasty alone. Arch Neurol. 2001;58(9):1410–3.
Ackerstaff RG, Suttorp MJ, van den Berg JC, Overtoom TT, Vos JA, Bal ET, Zanen P, Antonius Carotid Endarterectomy, Angioplasty, and Stenting Study Group. Prediction of early cerebral outcome by transcranial Doppler monitoring in carotid bifurcation angioplasty and stenting. J Vasc Surg. 2005;41(4):618–24.
Garami ZF, Bismuth J, Charlton-Ouw KM, Davies MG, Peden EK, Lumsden AB. Feasibility of simultaneous pre- and postfilter transcranial Doppler monitoring during carotid artery stenting. J Vasc Surg. 2009;49(2):340–4, 345.e1–2; discussion 345.
Abou-Chebl A, Yadav JS, Reginelli JP, Bajzer C, Bhatt D, Krieger DW. Intracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment. J Am Coll Cardiol. 2004;43(9):1596–601.
Dalman JE, Beenakkers IC, Moll FL, Leusink JA, Ackerstaff RG. Transcranial Doppler monitoring during carotid endarterectomy helps to identify patients at risk of postoperative hyperperfusion. Eur J Vasc Endovasc Surg. 1999;18(3):222–7.
Morrish W, Grahovac S, Douen A. Intracranial hemorrhage after stenting and angioplasty of extracranial carotid stenosis. AJNR Am J Neuroradiol. 2000;21:1911–6.
Censori B, Camerlingo M, Casto L, Partziguian T, Caverni L, Bonaldi G, Mamoli A. Carotid stents are not a source of microemboli late after deployment. Acta Neurol Scand. 2000;102(1):27–30.
Gaunt ME, Martin PJ, Smith JL, Bell PR, Naylor AR. Clinical relevance of intraoperative embolization detected by transcranial Doppler ultrasonography during carotid endarterectomy: a prospective study of 100 patients. Br J Surg. 1994;81:1435–9.
van Heesewijk HP, Vos JA, Louwerse ES, Van Den Berg JC, Overtoom TT, Ernst SM, Mauser HW, Moll FL, Ackerstaff RG, Carotid PTA and Stenting Collaborative Research Group. New brain lesions at MR imaging after carotid angioplasty and stent placement. Radiology. 2002;224(2):361–5.
Jaeger H, Mathias K, Drescher R, Hauth E, Bockisch G, Demirel E, Gissler HM. Clinical results of cerebral protection with a filter device during stent implantation of the carotid artery. Cardiovasc Intervent Radiol. 2001;24(4):249–56.
Wilkinson ID, Griffiths PD, Hoggard N, Cleveland TJ, Gaines PA, Macdonald S, McKevitt F, Venables GS. Short-term changes in cerebral microhemodynamics after carotid stenting. AJNR Am J Neuroradiol. 2003;24(8):1497–9.
Jaeger HJ, Mathias KD, Drescher R, Hauth E, Bockish G, Demirel E, Gissler HM. Diffusion-weighted MR imaging after angioplasty or angioplasty plus stenting of arteries supplying the brain. AJNR Am J Neuroradiol. 2001;22(7):1234–5.
Schluter M, Tubler T, Steffens JC, Mathey DG, Schofer J. Focal ischemia of the brain after neuroprotected carotid artery stenting. J Am Coll Cardiol. 2003;42(6):1014–6.
Crawley F, Stygall J, Lunn S, et al. Comparison of microembolism detected by transcranial Doppler and neuropsychological sequelae of carotid surgery and percutaneous transluminal angioplasty. Stroke. 2000;31:1329–34.
Sadoshima S, Heistad DD. Regional cerebral blood flow during hypotension in normotensive and stroke-prone spontaneously hypertensive rats: effect of sympathetic denervation. Stroke. 1983;14(4):575–9.
Moody DM, Brown WR, Challa VR, Stump DA, Reboussin DM, Legault C. Brain microemboli associated with cardiopulmonary bypass: a histologic and magnetic resonance imaging study. Ann Thorac Surg. 1995;59(5):1304–7.
Bettman MA, Katzen BT, Whisnant J, Brant-Zawadzki M, Broderick JP. Carotid stenting and angioplasty: a statement for healthcare professionals from the Councils on Cardiovascular Radiology, Stroke, Cardio-Thoracic and Vascular Surgery, Epidemiology, and Prevention, and Clinical Cardiology, American Heart Association. Circulation. 1998;97(1):121–3.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
Bates, M.C. (2013). Use of TCD in Monitoring Patients During Carotid Artery Stenting. In: AbuRahma, A., Bandyk, D. (eds) Noninvasive Vascular Diagnosis. Springer, London. https://doi.org/10.1007/978-1-4471-4005-4_14
Download citation
DOI: https://doi.org/10.1007/978-1-4471-4005-4_14
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-4004-7
Online ISBN: 978-1-4471-4005-4
eBook Packages: MedicineMedicine (R0)