Abstract
Zinc’s role in metabolism has been studied at many different levels, from its crucial presence at the active site of various enzymes to its more dubious efficacy in the treatment of various diseases. Somewhere between is its physiological role in normal growth. Cell biologists have established that zinc is essential for cell replication. In every animal species so far studied, growth failure is one of the earliest signs of experimental zinc deficiency. Paediatricians recognize failure to thrive as a major sign of zinc deficiency, inherited or dietary.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Ashworth A (1969) Growth rates in children recovering from protein—calorie malnutrition. Br J Nutr 23: 835–845
Brook OG, Wheeler EF (1976) High energy feeding in protein—energy malnutrition. Arch Dis Child 51: 968–971
Brooks CGD (1971) Determination of body composition of children from skinfold measurements. Arch Dis Child 46: 182–184
Brown ED, Chan W, Smith JC (1978) Bone mineralization during a developing zinc deficiency. Proc Soc Exp Biol Med 157: 211–214
Calhoun NR, McDaniel EG, Howard MP, Smith JC (1978) Loss of zinc from bone during deficiency state. Nutr Rep Intern 17: 299–306
Cheek DB, Hill DE, Cordano A, Graham GG (1970) Malnutrition in infancy: changes in muscle and adipose tissue before and after rehabilitation. Pediatr Res 4: 135–144
Chesters JK, Quarterman J (1970) Effects of zinc deficiency on food intake and feeding patterns of rats. Br J Nutr 24: 1061–1069
Chesters JK, Will M (1973) Some factors controlling food intake by zinc-deficient rats. Br J Nutr 30: 555–566
Diem K, Lentner C (1970) Scientific tables, 7th edn. Geigy, Basle, pp 517, 518
Flanagan PR (1984) A model to produce pure zinc deficiency in rats and its use to demonstrate that dietary phytate increases the excretion of endogenous zinc. J Nutr 114: 493–502
Garn SM (1963) Human biology and research in body composition. In: Brozek J (ed) Body composition, part II. Ann NY Acad Sci 10: 429–446
Golden BE, Golden MHN (1979) Plasma zinc and the clinical features of malnutrition. Am J Clin Nutr 32: 2490–2494
Golden BE, Golden MHN (1981a) Plasma zinc, rate of weight gain, and the energy cost of tissue deposition in children recovering from severe malnutrition on a cow’s milk or soya protein based diet. Am J Clin Nutr 34: 892–899
Golden BE, Golden MHN (1985) Effect of zinc supplementation on the composition of newly synthesized tissue in children recovering from malnutrition. Proc Nutr Soc 44: 110A
Golden MHN, Golden BE (1981b) Effect of zinc supplementation on the dietary intake, rate of weight gain, and energy cost of tissue deposition in children recovering from severe malnutrition. Am J Clin Nutr 34: 900–908
Golden MHN, Golden BE (1981c) Trace elements. Potential importance in human nutrition with particular reference to zinc and vanadium. Br Med Bull 37: 31–36
Golden M, Waterlow JC, Picou D (1977) The relationship between dietary intake, weight change, nitrogen balance and protein turnover in man. Am J Clin Nutr 30: 1345–1348
Golden MHN, Golden BE, Harland PSEG, Jackson AA (1978) Zinc and immunocompetence in protein-energy malnutrition. Lancet I: 1226–1228
Golden MHN, Golden BE, Jackson AA (1980) Skin breakdown in kwashiorkor responds to zinc. Lancet I: 1057 (letter)
Guigliano R, Millward DJ (1984) Growth and zinc homeostasis in the severely Zn-deficient rat. Br J Nutr 52: 545–560
Hambidge KM, Walravens PA, Neldner KH (1977) The role of zinc in the pathogenesis and treatment of acrodermatitis enteropathica. In: Brewer GJ, Prasad AS (eds) Zinc metabolism: current aspects in health and disease. Alan R. Liss Inc, New York, pp 329–340
Hansen-Smith FM, Picou D, Golden MH (1979) Growth of muscle fibres during recovery from severe malnutrition in Jamaican infants. Br J Nutr 41: 275–282
Harland BF, Spivey Fox MR, Fry BE Jr (1975) Protection against zinc deficiency by prior excess dietary zinc in young Japanese quail. J Nutr 105: 1509–1518
Harris PM, Widdowson EM (1978) Deposition of fat in the body of the rat during rehabilitation after early undernutrition. Br J Nutr 39: 201–211
Hurley LS, Tao S (1972) Alleviation of teratogenic effects of zinc deficiency by simultaneous lack of calcium. Am J Physiol 222: 322–325
Jackson AA, Picou D, Reeds PJ (1977) The energy cost of repleting tissue deficits during recovery from protein—energy malnutrition. Am J Clin Nutr 30: 1514–1517
Karlberg P (1976) The somatic development of children in a Swedish urban community. Acta Paediatr Scand Suppl 258: 48–55
Kerr D, Ashworth A, Picou D et al. (1973) Accelerated recovery from infant malnutrition with high calorie feeding. In: Gardner LI, Amacher P (eds) Endocrine aspects of malnutrition. The Kroc Foundation, California, pp 467–486
MacLean WC, Graham GG (1980) The effect of energy intake on nitrogen content of weight gained by recovering malnourished infants. Am J Clin Nutr 33: 903–909
Masters DG, Keen CL, Lönnerdal B, Hurley LS (1983) Zinc deficiency teratogenicity: the protective role of maternal tissue catabolism. J Nutr 113: 905–912
Miller ER, Luecke RW, Ullrey DE, Baltzer BV, Bradley BL, Hoefer JA (1968) Biochemical, skeletal and allometric changes due to zinc deficiency in the baby pig. J Nutr 95: 278–286
Mills CF, Dalgarno AC, Williams RB, Quarterman J (1967) Zinc deficiency and the zinc requirements of calves and lambs. Br J Nutr 21: 751–768
Montgomery RD (1962) Muscle morphology in infantile protein malnutrition. J Clin Pathol 15: 511–521
Morgan PN, Cardinet GC Jr, Keen CL, Lönnerdal B (1987) Effects of dietary zinc intake during recovery from undernutrition on mouse gastrocnemius muscle (GM). Fed Proc 46: 885 (abstract)
Murray EJ, Messer HH (1981) Turnover of bone zinc during normal and accelerated bone loss in rats. J Nutr 111: 1641–1647
National Research Council. Subcommittee on Zinc (1979) University Park Press, Baltimore, p 124
Park JHY, Grandjean CJ, Antonson DL, Vanderhoof JA (1986) Effects of isolated zinc deficiency on the composition of skeletal muscle, liver and bone during growth in rats. J. Nutr 116: 610–617
Reeds PJ, Jackson AA, Picou D, Poulter N (1978) Muscle mass and composition in malnourished infants and children and changes seen after recovery. Pediatr Res 12: 613–618
Swenerton H, Hurley LS (1968) Severe zinc deficiency in male and female rats. J Nutr 95: 8–18
Walravens PA, Hambidge KM (1976) Growth of infants fed a zinc supplemented formula. Am J Clin Nutr 29: 1114–1121
Walravens PA, Krebs NF, Hambidge KM (1983) Linear growth of low income preschool children receiving a zinc supplement. Am J Clin Nutr 38: 195–201
Waterlow JC (1961) The rate of recovery of malnourished infants in relation to the protein and calorie levels of the diet. J Trop Pediatr 7: 16–22
Widdowson EM (1974) Changes in pigs due to undernutrition before birth and for one, two and three years afterwards, and the effect of rehabilitation. Adv Exp Med Biol 49: 165–181
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Golden, B.E. (1989). Zinc in Cell Division and Tissue Growth: Physiological Aspects. In: Mills, C.F. (eds) Zinc in Human Biology. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-3879-2_8
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3879-2_8
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3881-5
Online ISBN: 978-1-4471-3879-2
eBook Packages: Springer Book Archive