Skip to main content

The Biology of the Major Histocompatibility Complex

  • Chapter
Transplantation Surgery

Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

  • 216 Accesses

Abstract

The rejection of tissues transplanted between two individuals of the same species (e.g. mouse to mouse or human to human) is the consequence of the immune recognition of the so-called “transplantation antigens”. These antigens, expressed on the surface of cells and tissues, have two functions. They stimulate the rejection response and act as target molecules for the various effector mechanisms of rejecton.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Further Reading

  • Auchincloss H, Sultan M. Antigen processing and presentation in transplantation. Curr Opin Immunol 1996; 8: 681–687.

    Article  PubMed  CAS  Google Scholar 

  • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. Structure of the human histocompatibility antigen, HLA-A2. Nature 1987; 329: 506–512.

    Article  PubMed  CAS  Google Scholar 

  • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 1987; 329: 512–518.

    Article  PubMed  CAS  Google Scholar 

  • Bodmer JG, Marsh SCE, Albert ED, Bodmer WF, Bontrop RE, Charron D, Dupont B, Erlich HA, Fauchet R, Mach B, Mayr WR, Parham P, Sasazuki T, Schreuder GMT, Strominger JL, Svejgaard A, Terasaki PI. Nomenclature for factors of the HLA system. Hum Immunol 1996; 53: 9–128.

    Google Scholar 

  • Brown JH, Jardetzky TS, Gorga JC, Stren JL, Urban RG, Strominger JL, Wiley DC. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993; 364: 33–39.

    Article  PubMed  CAS  Google Scholar 

  • Campbell RD, Trowsdale JT. Map of the human MHC. Immunology Today 1993; 14: 1353–1357.

    Article  Google Scholar 

  • Davis MM, Bjorkman PJ. T-cell antigen receptor genes and T-cell recognition. Nature 334: 95–102.Garrett TP, Saper MA, Bjorkman PJ, Strominger JL, Wiley DC (1989). Specificty pockets for the side chains of peptide antigens in HLAAw68. Nature 1998; 342: 692–696.

    Google Scholar 

  • Ghosh P, Amaya M, Mellins E, Wiley DC. The structure of an intermediate in class II MHC maturation: CLIP bound to HLADR3. Nature 1995; 378: 457–462.

    Article  PubMed  CAS  Google Scholar 

  • Lehner PJ, Cresswell P. Processing and delivery of peptides presented by MHC class I molecules. Curr Opin Immunol 1996; 8: 59–67.

    Article  PubMed  CAS  Google Scholar 

  • Neefjes JJ, Ploegh HL. Intracellular transport of MHC class II molecules. Immunology Today 1992; 13: 179–183.

    Article  PubMed  CAS  Google Scholar 

  • Olerup 0, Zetterquist H. HLA-DR typing by PCR with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39: 225–235.

    Article  PubMed  CAS  Google Scholar 

  • Roopenian DC. What are minor histocompatibility loci? A new look at an old question. Immunology Today 1992; 13: 7–10.

    Article  PubMed  CAS  Google Scholar 

  • Sloan VS, Cameron P, Porter G, Gammon M, Amaya M Mellins E, Zaller DM. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 1995; 375: 802–806.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag London

About this chapter

Cite this chapter

Hutchinson, I.V. (2001). The Biology of the Major Histocompatibility Complex. In: Hakim, N.S., Danovitch, G.M. (eds) Transplantation Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-4471-3689-7_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3689-7_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-859-1

  • Online ISBN: 978-1-4471-3689-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics