Skip to main content

PET Radiopharmaceuticals

  • Chapter
  • First Online:
Handbook of Nuclear Cardiology

Abstract

Cardiac PET perfusion and viability imaging has gained considerable acceptance in the cardiology and imaging communities due to the efficiency of testing procedures and excellent image quality. These attributes are in part due to the radiopharmaceuticals available for Cardiac PET. Most PET radiopharmaceuticals have radioisotopes with shorter half-lives than those of SPECT tracers. This enables patient imaging protocols to provide rapid repeat testing such as rest followed quickly by stress imaging (25–40 min). The short half-lives can also reduce radiation exposure for some PET agents. However the very short half-life for some PET perfusion agents means that exercise imaging is generally not possible. This may change with availability of newer slightly longer half-life PET tracers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Fowler JS, Wolf AP. Positron emission tomography and autoradiography principles and applications for the brain and heart. In: Phelps M, Mazziotta J, editors. Clinical cardiology. New York: Raven Press; 1986. p. 391–450.

    Google Scholar 

  2. Biersack H, Freeman L. Clinical nuclear medicine. Berlin/Heidelberg: Springer; 2007.

    Book  Google Scholar 

  3. IAEA. Cyclotron produced radionuclides: guidelines for setting up a facility. Vienna: IAEA; 2009. p. 213.

    Google Scholar 

  4. Herzog BA, Husmann L, Valenta I, Gaemperli O, Siegrist PT, Tay FM, Burkhard N, Wyss CA, Kaufmann PA. Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol. 2009;54:150–6.

    Article  PubMed  Google Scholar 

  5. Ziadi MC, Beanlands R, DeKemp R, Renaud J, Tee RE, Guo A, Williams K, Chow B, Ruddy TD, Hessian R, Garrard L, Davies RA, Etele J. Impaired mfr measured using Rb-82 predicts outcomes in patients with suspected ischemia. Circulation. 2009;120:S320.

    Google Scholar 

  6. Love WD, Burch GE. Influence of the rate of coronary plasma flow on the extraction of Rb86 from coronary blood. Circ Res. 1959;7:24–30.

    Article  PubMed  CAS  Google Scholar 

  7. Lortie M, Beanlands RS, Yoshinaga K, Klein R, Dasilva JN, DeKemp RA. Quantification of myocardial blood flow with 82Rb dynamic pet imaging. Eur J Nucl Med Mol Imaging. 2007;34:1765–74.

    Article  PubMed  Google Scholar 

  8. El Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, Fischman A, Coughlan M, Yasuda T, Di Carli MF. Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb pet: comparison with (13)N-ammonia pet. J Nucl Med. 2009;50:1062–71.

    Article  PubMed  Google Scholar 

  9. Klein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, deKemp RA. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program. J Nucl Cardiol. 2010;17:600–16.

    Article  PubMed  Google Scholar 

  10. Di Carli MF, Hachamovitch R. New technology for noninvasive evaluation of coronary artery disease. Circulation. 2007;115:1464–80.

    Article  PubMed  Google Scholar 

  11. Sampson UK, Dorbala S, Limaye A, Kwong R, Di Carli MF. Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease. J Am Coll Cardiol. 2007;49:1052–8.

    Article  PubMed  CAS  Google Scholar 

  12. Schelbert H. Quantifying myocardial perfusion for the assessment of preclinical cad. In: Cardiac PET and PET/CT. New York: Springer; 2007. p. 166–77.

    Google Scholar 

  13. Takala T, Nuutila P, Katoh C, Luotolahti M, Bergman J, Maki M, Oikonen V, Ruotsalainen U, Gronroos T, Haaparanta M, Kapanen J, Knuuti J. Myocardial blood flow, oxygen consumption and fatty acid uptake in endurance athletes during insulin stimulation. Am J Physiol. 1999;4(Pt 1):E585–90.

    Google Scholar 

  14. Hickey KT, Sciacca RR, Bokhari S, Rodriguez O, Chou RL, Faber TL, Cooke CD, Garcia EV, Nichols K, Bergmann SR. Assessment of cardiac wall motion and ejection fraction with gated pet using N-13 ammonia. Clin Nucl Med. 2004;29:243–8.

    Article  PubMed  Google Scholar 

  15. Maddahi J, Czernin J, Lazewatsky J, Huang SC, Dahlbom M, Schelbert H, Sparks R, Ehlgen A, Crane P, Zhu Q, Devine M, Phelps M. Phase I, first-in-human study of BMS747158, a novel 18F-labeled tracer for myocardial perfusion PET: dosimetry, biodistribution, safety, and imaging characteristics after a single injection at rest. J Nucl Med. 2011;52:1490–8.

    Article  PubMed  CAS  Google Scholar 

  16. Dilsizian V, Pohost GM, editors. Cardiac PET, CT and MR. Oxford: Wiley-Blackwell; 2010. p. 120–2.

    Google Scholar 

  17. Fuller RW, Snoddy HD, Perry KW, Bernstein JR, Murphy PJ. Formation of alpha-methylnorepinephrine as a metabolite of metaraminol in guinea pigs. Biochem Pharmacol. 1981;30:2831–6.

    Article  PubMed  CAS  Google Scholar 

  18. Matsunari I, Aoki H, Nomura Y, Takeda N, Chen WP, Taki J, Nakajima K, Nekolla SG, Kinuya S, Kajinami K. Iodine-123 metaiodobenzylguanidine imaging and carbon-11 hydroxyephedrine positron emission tomography compared in patients with left ventricular dysfunction. Circ Cardiovasc Imaging. 2010;3:595–603.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jean N. DaSilva Ph.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag London

About this chapter

Cite this chapter

DaSilva, J.N., Valadiva, A.C., Mylonas, I., Hadizad, T., deKemp, R.A., Beanlands, R.S.B. (2013). PET Radiopharmaceuticals. In: Heller, G., Hendel, R. (eds) Handbook of Nuclear Cardiology. Springer, London. https://doi.org/10.1007/978-1-4471-2945-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-2945-5_13

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2944-8

  • Online ISBN: 978-1-4471-2945-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics