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Sinonasal Cancer

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Occupational Cancers

Abstract

Sinonasal cancer, the cancer of the nose and paranasal cavities is a rare type of cancer. Its incidence varies between men (0.5–1.5 new cases annually per 100,000) and women (0.1–0.6/100,000) and also from country to country. These variations in incidence are mostly explained by differences in occupational exposure, in particular exposure to wood dust, which is by far the major risk factor. This chapter gives an overview of studies on sinonasal cancer dealing with epidemiological findings and various occupational risk factors, exposure levels and other exposure characteristics, tumor pathology, the molecular cancer mechanisms likely to be involved in the development of the disease, and, finally, molecular alterations observed in tumors and available as potential molecular markers. The main studies and their findings as well as the principal pathological features of sinonasal tumors are summarized in tables and exemplified in illustrations.

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Acknowledgements

We thank all our colleagues who participated in the research collaboration in connection with the EU 5 FW project WOODRISK (QLK-2000-00573) and afterwards. Dr. Ewen MacDonald, University of Eastern Finland, Kuopio, is thanked for language revision and Ms. Ritva Järnström, Finnish Institute of Occupational Health, Helsinki, for technical assistance.

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Authors and Affiliations

  1. Health and Work Ability, Systems Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41a A, FI-00250, Helsinki, Finland

    Kirsti Husgafvel-Pursiainen PhD

  2. UMS 011, Population-based Epidemiologic Cohorts Unit, Inserm – Versailles St-Quentin University, Villejuif, France

    Matthieu Carton MD

  3. Inserm UMR 1085 – Irset, Inserm (French National Institute of Health and Medical Research), Pointe-à-Pitre, Guadeloupe, French West Indies

    Danièle Luce PhD

  4. Health and Work Ability, Systems Toxicology/Pathology, Finnish Institute of Occupational Health, Helsinki, Finland

    C. Henrik J. Wolff MD

  5. Section of Molecular Carcinogenesis, International Agency for Research on Cancer, Lyon, France

    Reetta Holmila PhD

  6. Department of Public Health, Section for Environmental and Occupational Medicine, Aarhus University, Aarhus, Denmark

    Vivi Schlünssen MD, PhD

  7. Department of Biology, The Bioinformatics Centre, University of Copenhagen, Copenhagen, Denmark

    Jette Bornholdt PhD

  8. Research Center, Danish Cancer Society, Copenhagen, Denmark

    Johnni Hansen PhD

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  1. Kirsti Husgafvel-Pursiainen PhD
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  2. Matthieu Carton MD
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  6. Vivi Schlünssen MD, PhD
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  8. Johnni Hansen PhD
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Correspondence to Kirsti Husgafvel-Pursiainen PhD .

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Editors and Affiliations

  1. Helsinki University Central Hospital and Finnish Institute of Occupational Health, Helsinki, Finland

    Sisko Anttila

  2. Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Paolo Boffetta

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Husgafvel-Pursiainen, K. et al. (2014). Sinonasal Cancer. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_7

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