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Chapter Relative Effects of Vitamin D3 and Calcifediol

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Nutritional Influences on Bone Health

Abstract

This chapter evaluates differences between oral supplementation with calcifediol (25-hydroxyvitamin D) and vitamin D3 (cholecalciferol). Oral supplementation with calcifediol results in an immediate and sustained increase in serum 25-hydroxyvitamin D concentrations. This may be relevant in clinical care as higher circulating level of 25-hydroxyvitamin D can be reached much faster than on the standard supplementation with vitamin D3. However, whether calcifediol has additional benefits superior to vitamin D3 will need further investigation in an equivalent dose comparison trial.

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References

  1. Dawson-Hughes B, Mithal A, Bonjour JP, et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 2010;21:1151–4.

    Article  PubMed  CAS  Google Scholar 

  2. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.

    Article  PubMed  CAS  Google Scholar 

  3. Bischoff Ferrari HA, Burckhardt P, Quack-Loetscher K, et al. Vitamin D deficiency: evidence, safety, and recommendations for the Swiss population Report written by a group of experts on behalf of the Federal Commission for Nutrition (FCN) 2012 Approved by the Federal Commission for Nutrition on November 3, 2011. http://www.bag.admin.ch/themen/ernaehrung_bewegung/05207/13246/index.html?lang=en. Last accessed 16 Oct 2012.

  4. Bischoff-Ferrari HA, Orav EJ, Willett WC, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40–9.

    Article  PubMed  CAS  Google Scholar 

  5. Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int. 2010;21:1121–32.

    Article  PubMed  CAS  Google Scholar 

  6. Gallagher JC, Sai A, Templin 2nd T, Smith L. Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med. 2012;156:425–37.

    PubMed  Google Scholar 

  7. Haddad Jr JG, Rojanasathit S. Acute administration of 25-hydroxycholecalciferol in man. J Clin Endocrinol Metab. 1976;42:284–90.

    Article  PubMed  CAS  Google Scholar 

  8. Hahn TJ, Halstead LR, Teitelbaum SL, Hahn BH. Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration. J Clin Invest. 1979;64:655–65.

    Article  PubMed  CAS  Google Scholar 

  9. Stamp TC, Haddad JG, Twigg CA. Comparison of oral 25-hydroxycholecalciferol, vitamin D, and ultraviolet light as determinants of circulating 25-hydroxyvitamin D. Lancet. 1977;1:1341–3.

    Article  PubMed  CAS  Google Scholar 

  10. Colodro IH, Brickman AS, Coburn JW, Osborn TW, Norman AW. Effect of 25-hydroxy-vitamin D3 on intestinal absorption of calcium in normal man and patients with renal failure. Metabolism. 1978;27:745–53.

    Article  PubMed  CAS  Google Scholar 

  11. Stamp TC. Intestinal absorption of 25-hydroxycholecalciferol. Lancet. 1974;2:121–3.

    Article  PubMed  CAS  Google Scholar 

  12. Francis RM, Peacock M, Storer JH, Davies AE, Brown WB, Nordin BE. Calcium malabsorption in the elderly: the effect of treatment with oral 25-hydroxyvitamin D3. Eur J Clin Invest. 1983;13:391–6.

    Article  PubMed  CAS  Google Scholar 

  13. Bischoff-Ferrari HA, Dawson-Hughes B, Stöcklin E, et al. Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure and markers of innate immunity. J Bone Miner Res. 2011; [Epub ahead of print].

    Google Scholar 

  14. Cashman KD, Seamans KM, Lucey AJ, et al. Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. Am J Clin Nutr. 2012;95:1350–6.

    Article  PubMed  CAS  Google Scholar 

  15. Peacock M, Liu G, Carey M, et al. Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab. 2000;85:3011–9.

    Article  PubMed  CAS  Google Scholar 

  16. Sosa M, Lainez P, Arbelo A, Navarro MC. The effect of 25-dihydroxyvitamin D on the bone mineral metabolism of elderly women with hip fracture. Rheumatology (Oxford). 2000;39:1263–8.

    Article  CAS  Google Scholar 

  17. Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporos Int. 1998;8:222–30.

    Article  PubMed  CAS  Google Scholar 

  18. Smith JE, Goodman DS. The turnover and transport of vitamin D and of a polar metabolite with the properties of 25-hydroxycholecalciferol in human plasma. J Clin Invest. 1971;50:2159–67.

    Article  PubMed  CAS  Google Scholar 

  19. Garcia-Delgado I, Prieto S, Gil-Fraguas L, Robles E, Rufilanchas JJ, Hawkins F. Calcitonin, etidronate, and calcidiol treatment in bone loss after cardiac transplantation. Calcif Tissue Int. 1997;60:155–9.

    Article  PubMed  CAS  Google Scholar 

  20. Talalaj M, Gradowska L, Marcinowska-Suchowierska E, Durlik M, Gaciong Z, Lao M. Efficiency of preventive treatment of glucocorticoid-induced osteoporosis with 25-hydroxyvitamin D3 and calcium in kidney transplant patients. Transplant Proc. 1996;28:3485–7.

    PubMed  CAS  Google Scholar 

  21. Hillman LS, Hollis B, Salmons S, et al. Absorption, dosage, and effect on mineral homeostasis of 25-­hydroxycholecalciferol in premature infants: comparison with 400 and 800 IU vitamin D2 supplementation. J Pediatr. 1985;106:981–9.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Heike A. Bischoff-Ferrari MD, DrPH .

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Bischoff-Ferrari, H.A. (2013). Chapter Relative Effects of Vitamin D3 and Calcifediol. In: Burckhardt, P., Dawson-Hughes, B., Weaver, C. (eds) Nutritional Influences on Bone Health. Springer, London. https://doi.org/10.1007/978-1-4471-2769-7_18

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  • DOI: https://doi.org/10.1007/978-1-4471-2769-7_18

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