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Poststroke Aggressiveness

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Neuropsychiatric Symptoms of Cerebrovascular Diseases

Part of the book series: Neuropsychiatric Symptoms of Neurological Disease ((NSND))

Abstract

Aggressiveness is not a medical diagnosis. It corresponds to behavioral changes that patients display often in the acute, subacute, and chronic phases of stroke. These changes are related to the emotion of anger and associate variably with the anger trait, hostility, impulsivity, disruptiveness, confusion, agitation, anxiety, depression, and some cognitive changes which could be specific or not to the localization of the vascular lesion. For assessment purposes, it is important that poststroke aggressiveness represents a significant change in comparison to the prestroke condition and that it has sufficient clinical severity to be considered distressing and producing significant interference with personal and social patterns of functioning.

The link between aggressiveness and regional brain dysfunction remains still poorly understood.

In order to achieve a better comprehension of aggressiveness-related states and to finalize effective interventions, we propose to organize them in categories which are specific to poststroke disorders taxonomies (such as the dysexecutive syndrome; catastrophic reactions, aphasia and other left hemisphere syndromes; misoplegia, somatoparaphrenia, misidentification disorders, and other right hemisphere syndromes; poststroke delirium, mania, psychosis, and mood disorders; poststroke pain and fatigue conditions; and vascular dementia).

Additional studies with clinically meaningful long-term outcomes are required to identify and support pharmacological and behavioral interventions. Drug therapy for poststroke agitation and aggression remains a significant research issue.

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References

  1. Ghika-Schmid F, van Melle G, Guex P, Bogousslavsky J. Subjective experience and behavior in acute stroke: the Lausanne Emotion in Acute Stroke Study. Neurology. 1999;52(1):22–8.

    Article  PubMed  CAS  Google Scholar 

  2. Aybek S, Carota A, Ghika-Schmid F, Berney A, Melle GV, Guex P, Bogousslavsky J. Emotional behavior in acute stroke: the Lausanne emotion in stroke study. Cogn Behav Neurol. 2005;18(1):37–44.

    Article  PubMed  Google Scholar 

  3. Kim JS, Choi S, Kwon SU, Seo YS. Inability to control anger or aggression after stroke. Neurology. 2002;58(7):1106–8.

    Article  PubMed  CAS  Google Scholar 

  4. Buijck BI, Zuidema SU, Spruit-van Eijk M, Geurts AC, Koopmans RT. Neuropsychiatric symptoms in geriatric patients admitted to skilled nursing facilities in nursing homes for rehabilitation after stroke: a longitudinal multicenter study. Int J Geriatr Psychiatry. 2012;27(7):734–41.

    PubMed  Google Scholar 

  5. Barratt ES, Stanford MS, Dowdy L, Liebman MJ, Kent TA. Impulsive and premeditated aggression: a factor analysis of self-reported acts. Psychiatry Res. 1999;86(2):163–73.

    Article  PubMed  CAS  Google Scholar 

  6. Malone RP, Bennett DS, Luebbert JF, Rowan AB, Biesecker KA, Blaney BL, Delaney MA. Aggression classification and treatment response. Psychopharmacol Bull. 1998;34(1):41–5.

    PubMed  CAS  Google Scholar 

  7. Barrett AM. Rose-colored answers: neuropsychological deficits and patient-reported outcomes after stroke. Behav Neurol. 2010;22(1–2):17–23.

    PubMed  Google Scholar 

  8. Damasio AR. Descartes’ error: emotion, reason, and the human brain. Harper Perennial; 1995.

    Google Scholar 

  9. Hussey M. I’m no longer silent. Top Stroke Rehabil. 2010;17(1):6–9.

    Article  PubMed  Google Scholar 

  10. Greenop KR, Almeida OP, Hankey GJ, van Bockxmeer F, Lautenschlager NT. Premorbid personality traits are associated with post-stroke behavioral and psychological symptoms: a three-month follow-up study in Perth, Western Australia. Int Psychogeriatr. 2009;21(6):1063–71.

    Article  PubMed  Google Scholar 

  11. Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357–81.

    Article  PubMed  CAS  Google Scholar 

  12. Bonelli RM, Cummings JL. Frontal-subcortical circuitry and behavior. Dialogues Clin Neurosci. 2007;9(2):141–51.

    PubMed  Google Scholar 

  13. Luria AR. Frontal lobe syndromes. In: Vinken PJ, Bruyn GW, editors. Handbook of clinical neurology II. New York: Elsevier; 1969.

    Google Scholar 

  14. Stuss DT, Benson DF. The frontal lobes. New York: Raven; 1986.

    Google Scholar 

  15. Bogousslavsky J, Regli F. Anterior cerebral artery territory infarction in the Lausanne Stroke Registry. Clinical and etiologic patterns. Arch Neurol. 1990;47(2):144–50.

    Article  PubMed  CAS  Google Scholar 

  16. Borggreve F, De Deyn PP, Mariën P, Cras P, Dierckx RA. Bilateral infarction in the anterior cerebral artery vascular territory due to an unusual anomaly of the circle of Willis. Stroke. 1994;25(6):1279–81.

    Article  PubMed  CAS  Google Scholar 

  17. Kang SY, Kim JS. Anterior cerebral artery infarction: stroke mechanism and clinical-imaging study in 100 patients. Neurology. 2008;70:2386–93.

    Article  PubMed  Google Scholar 

  18. Starkstein SE, Robinson RG. Mechanism of disinhibition after brain lesions. J Nerv Ment Dis. 1997;185(2):108–14.

    Article  PubMed  CAS  Google Scholar 

  19. Mendez MF, Adams NL, Lewandowski KS. Neurobehavioral changes associated with caudate lesions. Neurology. 1989;39(3):349–54.

    Article  PubMed  CAS  Google Scholar 

  20. Bogousslavsky J, Ferrazzini M, Regli F, Assal G, Tanabe H, Delaloye-Bischof A. Manic delirium and frontal-like syndrome with paramedian infarction of the right thalamus. J Neurol Neurosurg Psychiatry. 1988;51(1):116–9.

    Article  PubMed  CAS  Google Scholar 

  21. Beer JS, John OP, Scabini D, Knight RT. Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions. J Cogn Neurosci. 2006;18(6):871–9.

    Article  PubMed  Google Scholar 

  22. Grafman J, Schwab K, Warden D, Pridgen A, Brown HR, Salazar AM. Frontal lobe injuries, violence, and aggression: a report of the Vietnam head injury study. Neurology. 1996;46(5):1231–8.

    Article  PubMed  CAS  Google Scholar 

  23. Best M, Williams JM, Coccaro EF. Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder. Proc Natl Acad Sci U S A. 2002;99(12):8448–53.

    Article  PubMed  CAS  Google Scholar 

  24. Damasio AR, Tranel D, Damasio H. Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav Brain Res. 1990;41(2):81–94.

    Article  PubMed  CAS  Google Scholar 

  25. Bechara A, Damasio H, Tranel D, Damasio AR. Deciding advantageously before knowing the advantageous strategy. Science. 1997;275(5304):1293–5.

    Article  PubMed  CAS  Google Scholar 

  26. Raine A, Yang Y. Neural foundations to moral reasoning and antisocial behavior. Soc Cogn Affect Neurosci. 2006;1(3):203–13.

    Article  PubMed  Google Scholar 

  27. Roelofs K, Minelli A, Mars RB, van Peer J, Toni I. On the neural control of social emotional behavior. Soc Cogn Affect Neurosci. 2009;4(1):50–8.

    Article  PubMed  Google Scholar 

  28. Kühn S, Gallinat J, Brass M. “Keep calm and carry on”: structural correlates of expressive suppression of emotions. PLoS One. 2011;6(1):e16569.

    Article  PubMed  Google Scholar 

  29. Stuss DT, Gow CA, Hetherington CR. “No longer Gage”: frontal lobe dysfunction and emotional changes. J Consult Clin Psychol. 1992;60(3):349–59.

    Article  PubMed  CAS  Google Scholar 

  30. Harmon-Jones E. Early Career Award. Clarifying the emotive functions of asymmetrical frontal cortical activity. Psychophysiology. 2003;40(6):838–48.

    Article  PubMed  Google Scholar 

  31. Carr L, Iacoboni M, Dubeau M-C, Mazziotta JC, Lenzi GL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci U S A. 2003;100(9):5497–502.

    Article  PubMed  CAS  Google Scholar 

  32. Happé F, Brownell H, Winner E. Acquired “theory of mind” impairments following stroke. Cognition. 1999;70(3):211–40.

    Article  PubMed  Google Scholar 

  33. Apperly IA, Samson D, Chiavarino C, Humphreys GW. Frontal and temporo-parietal lobe contributions to theory of mind: neuropsychological evidence from a false-belief task with reduced language and executive demands. J Cogn Neurosci. 2004;16(10):1773–84.

    Article  PubMed  Google Scholar 

  34. Apperly IA, Samson D, Chiavarino C, Bickerton W-L, Humphreys GW. Testing the domain-specificity of a theory of mind deficit in brain-injured patients: evidence for consistent performance on non-verbal, “reality-unknown” false belief and false photograph tasks. Cognition. 2007;103(2):300–21.

    Article  PubMed  Google Scholar 

  35. Samson D, Apperly IA, Humphreys GW. Error analyses reveal contrasting deficits in “theory of mind”: neuropsychological evidence from a 3-option false belief task. Neuropsychologia. 2007;45(11):2561–9.

    Article  PubMed  Google Scholar 

  36. Weed E, McGregor W, Feldbaek Nielsen J, Roepstorff A, Frith U. Theory of mind in adults with right hemisphere damage: what’s the story? Brain Lang. 2010;113(2):65–72.

    Article  PubMed  Google Scholar 

  37. Hoffmann M, Cases LB, Hoffmann B, Chen R. The impact of stroke on emotional intelligence. BMC Neurol. 2010;10:103.

    Article  PubMed  Google Scholar 

  38. Starkstein SE, Fedoroff JP, Price TR, Leiguarda R, Robinson RG. Catastrophic reaction after cerebrovascular lesions: frequency, correlates, and validation of a scale. J Neuropsychiatry Clin Neurosci. 1993;5(2):189–94.

    PubMed  CAS  Google Scholar 

  39. Carota A, Rossetti AO, Karapanayiotides T, Bogousslavsky J. Catastrophic reaction in acute stroke: a reflex behavior in aphasic patients. Neurology. 2001;57(10):1902–5.

    Article  PubMed  CAS  Google Scholar 

  40. Pia L, Neppi-Modona M, Ricci R, Berti A. The anatomy of anosognosia for hemiplegia: a meta-analysis. Cortex. 2004;40(2):367–77.

    Article  PubMed  Google Scholar 

  41. Vocat R, Staub F, Stroppini T, Vuilleumier P. Anosognosia for hemiplegia: a clinical-anatomical prospective study. Brain. 2010;133:3578–97.

    Article  PubMed  Google Scholar 

  42. Yang Z-H, Zhao X-Q, Wang C-X, Chen H-Y, Zhang Y-M. Neuroanatomic correlation of the post-stroke aphasias studied with imaging. Neurol Res. 2008;30(4):356–60.

    Article  PubMed  Google Scholar 

  43. Ogar JM, Baldo JV, Wilson SM, Brambati SM, Miller BL, Dronkers NF, Gorno-Tempinii ML. Semantic dementia and persisting Wernicke’s aphasia: linguistic and anatomical profiles. Brain Lang. 2011;117(1):28–33.

    Article  PubMed  CAS  Google Scholar 

  44. Liechty JA. The sounds of silence: relating to people with aphasia. J Psychosoc Nurs Ment Health Serv. 2006;44(8):53–5.

    PubMed  Google Scholar 

  45. van der Meulen I, van de Sandt-Koenderman WME, Duivenvoorden HJ, Ribbers GM. Measuring verbal and non-verbal communication in aphasia: reliability, validity, and sensitivity to change of the Scenario Test. Int J Lang Commun Disord. 2010;45((4):424–35.

    Article  PubMed  Google Scholar 

  46. Stone J, Townend E, Kwan J, Haga K, Dennis MS, Sharpe M. Personality change after stroke: some preliminary observations. J Neurol Neurosurg Psychiatry. 2004;75(12):1708–13.

    Article  PubMed  CAS  Google Scholar 

  47. Ferro JM, Caeiro L, Santos C. Poststroke emotional and behavior impairment: a narrative review. Cerebrovasc Dis. 2009;27 Suppl 1:197–203.

    Article  PubMed  Google Scholar 

  48. Berthier ML, Kulisevsky J, Gironell A, Fernández Benitez JA. Poststroke bipolar affective disorder: clinical subtypes, concurrent movement disorders, and anatomical correlates. J Neuropsychiatry Clin Neurosci. 1996;8(2):160–7.

    PubMed  CAS  Google Scholar 

  49. Mimura M, Nakagome K, Hirashima N, Ishiwata H, Kamijima K, Shinozuka A, Matsuda H. Left frontotemporal hyperperfusion in a patient with post-stroke mania. Psychiatry Res. 2005;139(3):263–7.

    Article  PubMed  Google Scholar 

  50. Hoffmann M. Isolated right temporal lobe stroke patients present with Geschwind Gastaut syndrome, frontal network syndrome and delusional misidentification syndromes. Behav Neurol. 2008;20(3):83–9.

    PubMed  Google Scholar 

  51. Santos CO, Caeiro L, Ferro JM, Figueira ML. Mania and stroke: a systematic review. Cerebrovasc Dis. 2011;32(1):11–21. Available from: 21576938.

    Article  PubMed  Google Scholar 

  52. Chemerinski E, Robinson RG. The neuropsychiatry of stroke. Psychosomatics. 2000;41(1):5–14.

    Article  PubMed  CAS  Google Scholar 

  53. Kumral E, Oztürk O. Delusional state following acute stroke. Neurology. 2004;62(1):110–3.

    Article  PubMed  Google Scholar 

  54. Förstl H, Almeida OP, Owen AM, Burns A, Howard R. Psychiatric, neurological and medical aspects of misidentification syndromes: a review of 260 cases. Psychol Med. 1991;21(4):905–10.

    Article  PubMed  Google Scholar 

  55. Lee K, Shinbo M, Kanai H, Nagumo Y. Reduplicative paramnesia after a right frontal lesion. Cogn Behav Neurol. 2011;24(1):35–9.

    Article  PubMed  Google Scholar 

  56. Spiegel DR, Laroia R, Samuels D. A possible case of Capgras syndrome after a right anterior cerebral artery cerebrovascular accident treated successfully with mirtazapine. J Neuropsychiatry Clin Neurosci. 2008;20(4):494.

    Article  PubMed  Google Scholar 

  57. de Pauw KW, Szulecka TK, Poltock TL. Frégoli syndrome after cerebral infarction. J Nerv Ment Dis. 1987;175(7):433–8.

    Article  PubMed  Google Scholar 

  58. Shi Q, Presutti R, Selchen D, Saposnik G. Delirium in acute stroke: a systematic review and meta-analysis. Stroke. 2012;43(3):645–9.

    Article  PubMed  Google Scholar 

  59. Carin-Levy G, Mead GE, Nicol K, Rush R, van Wijck F. Delirium in acute stroke: screening tools, incidence rates and predictors: a systematic review. J Neurol. 2012;259(8):1590–9.

    Article  PubMed  CAS  Google Scholar 

  60. Melkas S, Laurila JV, Vataja R, Oksala N, Jokinen H, Pohjasvaara T, Leppävuori A, Kaste M, Karhunen PJ, Erkinjuntti T. Post-stroke delirium in relation to dementia and long-term mortality. Int J Geriatr Psychiatry. 2012;27(4):401–8.

    PubMed  Google Scholar 

  61. Trzepacz PT, Baker RW, Greenhouse J. A symptom rating scale for delirium. Psychiatry Res. 1988;23(1):89–97.

    Article  PubMed  CAS  Google Scholar 

  62. Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990;113(12):941–8.

    Article  PubMed  CAS  Google Scholar 

  63. Critchley M. Misoplegia, or hatred of hemiplegia. Mt Sinai J Med. 1974;41(1):82–7.

    PubMed  CAS  Google Scholar 

  64. Baier B, Karnath H-O. Tight link between our sense of limb ownership and self-awareness of actions. Stroke. 2008;39(2):486–8.

    Article  PubMed  Google Scholar 

  65. Pearce JMS. Misoplegia. Eur Neurol. 2007;57(1):62–4.

    Article  PubMed  CAS  Google Scholar 

  66. Feinberg TE, Venneri A, Simone AM, Fan Y, Northoff G. The neuroanatomy of asomatognosia and somatoparaphrenia. J Neurol Neurosurg Psychiatry. 2010;81(3):276–81.

    Article  PubMed  Google Scholar 

  67. Gandola M, Invernizzi P, Sedda A, Ferrè ER, Sterzi R, Sberna M, Paulesu E, Bottini G. An anatomical account of somatoparaphrenia. Cortex. 2012;48(9):1165–78.

    Article  PubMed  Google Scholar 

  68. Dumais A, Lesage AD, Alda M, Rouleau G, Dumont M, Chawky N, Roy M, Mann JJ, Benkelfat C, Turecki G. Risk factors for suicide completion in major depression: a case–control study of impulsive and aggressive behaviors in men. Am J Psychiatry. 2005;162(11):2116–24.

    Article  PubMed  CAS  Google Scholar 

  69. Baca-García E, Oquendo MA, Saiz-Ruiz J, Mann JJ, de Leon J. A pilot study on differences in aggression in New York City and Madrid, Spain, and their possible impact on suicidal behavior. J Clin Psychiatry. 2006;67(3):375–80.

    Article  PubMed  Google Scholar 

  70. Santos CO, Caeiro L, Ferro JM, Figueira ML. A study of suicidal thoughts in acute stroke patients. J Stroke Cerebrovasc Dis. 2012;21(8):749–54.

    Article  PubMed  Google Scholar 

  71. Fuller-Thomson E, Tulipano MJ, Song M. The association between depression, suicidal ideation, and stroke in a population-based sample. Int J Stroke. 2012;7(3):188–94.

    PubMed  Google Scholar 

  72. Forsström E, Hakko H, Nordström T, Räsänen P, Mainio A. Suicide in patients with stroke: a population-based study of suicide victims during the years 1988–2007 in northern Finland. J Neuropsychiatry Clin Neurosci. 2010;22(2):182–7.

    Article  PubMed  Google Scholar 

  73. Katayama M, Naritomi H, Oomura M, Nukata M, Yamamoto S, Araki K, et al. Case reports of unexpected suicides in patients within six months after stroke. Kobe J Med Sci. 2011;56(5):E184–94.

    PubMed  Google Scholar 

  74. Bogousslavsky J. “The adventure”: Charles-Ferdinand Ramuz’s extraordinary stroke diary. Front Neurol Neurosci. 2010;27:207–15.

    Article  PubMed  CAS  Google Scholar 

  75. Tang WK, Chen Y, Lu J, Liang H, Chu WC, Tong Mok VC, Ungvari GS, Wong KS. Frontal infarcts and anxiety in stroke. Stroke. 2012;43(5):1426–8.

    Article  PubMed  Google Scholar 

  76. Campbell Burton CA, Holmes J, Murray J, Gillespie D, Lightbody CE, Watkins CL, Knapp P. Interventions for treating anxiety after stroke. Cochrane Database Syst Rev. 2012;3, CD008390.

    Google Scholar 

  77. Klit H, Finnerup NB, Overvad K, Andersen G, Jensen TS. Pain following stroke: a population-based follow-up study. PLoS One. 2011;6(11):e27607. Cited 2011 Nov 28.

    Article  PubMed  CAS  Google Scholar 

  78. Naess H, Lunde L, Brogger J. The triad of pain, fatigue and depression in ischemic stroke patients: the Bergen Stroke Study. Cerebrovasc Dis. 2012;33(5):461–5.

    Article  PubMed  Google Scholar 

  79. Dromerick A, Reding M. Medical and neurological complications during inpatient stroke rehabilitation. Stroke. 1994;25(2):358–61.

    Article  PubMed  CAS  Google Scholar 

  80. Wetzels RB, Zuidema SU, de Jonghe JFM, Verhey FRJ, Koopmans RTCM. Course of neuropsychiatric symptoms in residents with dementia in nursing homes over 2-year period. Am J Geriatr Psychiatry. 2010;18(12):1054–65.

    Article  PubMed  Google Scholar 

  81. Staekenborg SS, Su T, van Straaten EC, Lane R, Scheltens P, Barkhof F, van der Flier WM. Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease. J Neurol Neurosurg Psychiatry. 2010;81(5):547–51.

    Article  PubMed  Google Scholar 

  82. Croquelois A, Bogousslavsky J. Stroke aphasia: 1,500 consecutive cases. Cerebrovasc Dis. 2011;31(4):392–9.

    Article  PubMed  Google Scholar 

  83. Azouvi P, Samuel C, Louis-Dreyfus A, Bernati T, Bartolomeo P, Beis JM, Chokron S, Leclercq M, Marchal F, Martin Y, De Montety G, Olivier S, Perennou D, Pradat-Diehl P, Prairial C, Rode G, Siéroff E, Wiart L, Rousseaux M, French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO). Sensitivity of clinical and behavioural tests of spatial neglect after right hemisphere stroke. J Neurol Neurosurg Psychiatry. 2002;73(2):160–6.

    Article  PubMed  CAS  Google Scholar 

  84. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308–14.

    Article  PubMed  CAS  Google Scholar 

  85. Paradiso S, Robinson RG, Arndt S. Self-reported aggressive behavior in patients with stroke. J Nerv Ment Dis. 1996;184(12):746–53.

    Article  PubMed  CAS  Google Scholar 

  86. Chan K-L, Campayo A, Moser DJ, Arndt S, Robinson RG. Aggressive behavior in patients with stroke: association with psychopathology and results of antidepressant treatment on aggression. Arch Phys Med Rehabil. 2006;87(6):793–8.

    Article  PubMed  Google Scholar 

  87. Santos CO, Caeiro L, Ferro JM, Albuquerque R, Luísa Figueira M. Anger, hostility and aggression in the first days of acute stroke. Eur J Neurol. 2006;13(4):351–8.

    Article  PubMed  CAS  Google Scholar 

  88. Botez SA, Carrera E, Maeder P, Bogousslavsky J. Aggressive behavior and posterior cerebral artery stroke. Arch Neurol. 2007;64(7):1029–33.

    Article  PubMed  Google Scholar 

  89. Ballard C, Corbett A. Management of neuropsychiatric symptoms in people with dementia. CNS Drugs. 2010;24(9):729–39.

    PubMed  Google Scholar 

  90. Miller DD, Caroff SN, Davis SM, Rosenheck RA, McEvoy JP, Saltz BL, Riggio S, Chakos MH, Swartz MS, Keefe RS, Stroup TS, Lieberman JA, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Extrapyramidal side-effects of antipsychotics in a randomised trial. Br J Psychiatry. 2008;193(4):279–88.

    Article  PubMed  Google Scholar 

  91. Uçok A, Gaebel W. Side effects of atypical antipsychotics: a brief overview. World Psychiatry. 2008;7(1):58–62.

    PubMed  Google Scholar 

  92. Salzman C, Wolfson AN, Schatzberg A, Looper J, Henke R, Albanese M, Schwartz J, Miyawaki E. Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. J Clin Psychopharmacol. 1995;15(1):23–9.

    Article  PubMed  CAS  Google Scholar 

  93. Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997;54(12):1081–8.

    Article  PubMed  CAS  Google Scholar 

  94. Pollock BG, Mulsant BH, Rosen J, Mazumdar S, Blakesley RE, Houck PR, Huber KA. A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. Am J Geriatr Psychiatry. 2007;15(11):942–52.

    Article  PubMed  Google Scholar 

  95. Pollock BG, Mulsant BH, Rosen J, Sweet RA, Mazumdar S, Bharucha A, Marin R, Jacob NJ, Huber KA, Kastango KB, Chew ML. Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. Am J Psychiatry. 2002;159(3):460–5.

    Article  PubMed  Google Scholar 

  96. Choi-Kwon S, Han SW, Kwon SU, Kang D-W, Choi JM, Kim JS. Fluoxetine treatment in poststroke depression, emotional incontinence, and anger proneness: a double-blind, placebo-controlled study. Stroke. 2006;37(1):156–61.

    Article  PubMed  CAS  Google Scholar 

  97. Fleminger S, Greenwood RJ, Oliver DL. Pharmacological management for agitation and aggression in people with acquired brain injury. Cochrane Database Syst Rev. 2006;4, CD003299.

    PubMed  Google Scholar 

  98. Glenn MB, Wroblewski B, Parziale J, Levine L, Whyte J, Rosenthal M. Lithium carbonate for aggressive behavior or affective instability in ten brain-injured patients. Am J Phys Med Rehabil. 1989;68(5):221–6.

    Article  PubMed  CAS  Google Scholar 

  99. Chang K, Zhang H, Xia Y, Chen C. Testing the effectiveness of knowledge and behavior therapy in patients of hemiplegic stroke. Top Stroke Rehabil. 2011;18(5):525–35.

    Article  PubMed  Google Scholar 

  100. Ramírez JM, Andreu JM. Aggression, and some related psychological constructs (anger, hostility, and impulsivity); some comments from a research project. Neurosci Biobehav Rev. 2006;30(3):276–91.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Center for Brain and Nervous System Disorders, Genolier Swiss Medical Network Neurocenter and Department of Neurology, Clinique Genolier, Rte du Muids 3 - CP 100, Genolier, CH-1272, Switzerland

    A. Carota

  2. Center for Brain and Nervous System Disorders, Genolier Swiss Medical Network Neurocenter and Department of Neurology and Neurorehabilitation, Clinique Valmont, Glion, Switzerland

    J. Bogousslavsky

  3. Division of Molecular and Cognitive Neuroscience, Basel University, Basel, Switzerland

    P. Calabrese

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  1. A. Carota
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  2. J. Bogousslavsky
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  3. P. Calabrese
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Correspondence to A. Carota .

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  1. , Serviço de Neurologia, Hospital de Santa Maria, Av. Prof. Egas Moniz, Lisboa, 1649-035, Portugal

    José M. Ferro

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Carota, A., Bogousslavsky, J., Calabrese, P. (2013). Poststroke Aggressiveness. In: Ferro, J. (eds) Neuropsychiatric Symptoms of Cerebrovascular Diseases. Neuropsychiatric Symptoms of Neurological Disease. Springer, London. https://doi.org/10.1007/978-1-4471-2428-3_8

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