Abstract
Microdialysis has been an instrumental sampling technique to study ocular pharmacokinetics without sacrificing a huge number of animals. It has undergone significant transformations in the last decade and several animal models have been established for sampling inaccessible posterior segment tissues such as vitreous humor. Remarkable progress has been made in the probe design and validation techniques. In the following chapter we have discussed the principle and development of various animal models related to posterior segments.
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Abbreviations
- ACV:
-
Acyclovir
- AZdU:
-
3′-Azido-2′,3′-dideoxyuridine
- AZT:
-
Zidovudine
- E17βG:
-
17-β-glucoronide
- GCV:
-
Ganciclovir
- PLGA:
-
Poly(dl-lactide-co-glycolide)
- PLGA-PEG-PLGA:
-
Poly(dl-lactide-co-glycolide)-poly(ethylene glycol)-poly(dl-lactide-co-glycolide)
- VACV:
-
Val-acyclovir
- VVACV:
-
Val-val-acyclovir
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Acknowledgment
Supported by National Institutes of Health grants R01EY 09171–16 and R01EY 10659–14.
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Vaishya, R.D., Ananthula, H.K., Mitra, A.K. (2011). Microdialysis for Vitreal Pharmacokinetics. In: Kompella, U., Edelhauser, H. (eds) Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9920-7_2
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DOI: https://doi.org/10.1007/978-1-4419-9920-7_2
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