Abstract
A strategy to deliver drugs to the posterior segment of the eye is via a combination of physical methods to place the drug adjacent to the target cell and to open the cell membrane so that the drug can pass into the cell. Electric fields can be used to transport small and large charged molecules and to open pores in the plasma membrane. Here we review these physical methods and the progress to exploit electric fields in drug delivery.
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© 2011 American Association of Pharmaceutical Scientists
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Nickerson, J.M., Boatright, J.H. (2011). Drug and Gene Therapy Mediated by Physical Methods. In: Kompella, U., Edelhauser, H. (eds) Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9920-7_16
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DOI: https://doi.org/10.1007/978-1-4419-9920-7_16
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