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Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer

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Insulin Resistance and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 1))

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Abstract

Numerous lines of evidence indicate that insulin and its receptor regulate cell proliferation, survival and transformation, and thus, tumorigenesis [52]. Indeed, the fact that insulin has a potent tumor-promoting activity has been known for a long time. In wild-type animals, administration of exogenous insulin markedly enhances development of experimental breast and colon tumors [34, 68, 117]. In contrast, insulinopenia in animals with chemically-induced type 1 diabetes (T1D) results in a significantly reduced tumor growth, which is restored after insulin administration [29, 67, 112, 113]. Moreover, intraportal implantation of pancreatic islets in rats with T1D creates an insulin-enriched microenvironment, which promotes hepatocarcinogenesis [43]. The aforementioned studies thus link insulin and cancer mechanistically, and indicate that insulin plays the role of both a tumor initiator and promoter.

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Authors and Affiliations

  1. Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, 10029, USA

    Ruslan Novosyadlyy, Archana Vijayakumar, Yvonne Fierz & Derek LeRoith

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  1. Ruslan Novosyadlyy
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  2. Archana Vijayakumar
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  3. Yvonne Fierz
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  4. Derek LeRoith
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Correspondence to Derek LeRoith .

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  1. Mount Sinai Hospital, Dept. Medicine, University of Toronto, Murray St. 60, Toronto, M5T 3L9, Ontario, Canada

    I. George Fantus

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Novosyadlyy, R., Vijayakumar, A., Fierz, Y., LeRoith, D. (2011). Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer. In: Fantus, I. (eds) Insulin Resistance and Cancer. Energy Balance and Cancer, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9911-5_6

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