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The Physics of Aerosol Droplet and Particle Generation from Inhalers

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Controlled Pulmonary Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

The three major aerosolization systems comprised of nebulizers, ­propellant based systems, and dry powder inhalers, each has unique physical ­principles. A good understanding of these physical principles is required for the successful development. Therefore, in this chapter, several important empirical and scientific principles that include the particle generation, the formulation implication, and drug aerosolization mechanisms of each aerosolization systems are highlighted. Examples of particle engineering to achieve aerodynamically favorable dry powder aerosols are briefly discussed. Next generation inhaler products will be expedited if these physical mechanisms are understood.

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  1. Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599-7360, USA

    Anthony J. Hickey

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  1. Zhen Xu
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  1. , Pharmaceutics Division - PHR 4.214, University of Texas, University Station 1, Austin, 78712, USA

    Hugh D.C. Smyth

  2. Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, 27599, North Carolina, USA

    Anthony J. Hickey

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Xu, Z., Hickey, A.J. (2011). The Physics of Aerosol Droplet and Particle Generation from Inhalers. In: Smyth, H., Hickey, A. (eds) Controlled Pulmonary Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9745-6_4

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