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Synaptic Signaling in Ischemic Tolerance

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Innate Tolerance in the CNS

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

While a role of glutamate receptors in mediating the harmful effects of stroke was reported over 20 years ago, the role of the synapse in mediating ischemia and ischemic tolerance have been relatively less well studied. In this chapter, I will discuss the role of the major excitatory and inhibitory systems in the brain in mediating either the induction of tolerance following preconditioning or the effect of tolerance, i.e., neuroprotection. Finally, we will review exciting new work which highlights the dynamic nature of the synapse and rapid remodeling events in the synapse that may identify novel approaches for neuroprotection.

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Acknowledgments

Robert Meller is currently funded by the NIH (NS59588). Institutional support at the Neuroscience Institute at Morehouse School of Medicine was provided by NIH/NCRR/RCMI grants G12-RR03034, U54 NS060659, and S21MD000101–10. Previous funding support provided by NIH grants NS050669 and NS054023 (Meller), NS024728 (Roger Simon), and the American Heart Association 0465430Z (Meller). Dr. Meller would like to thank collaborators and colleagues both past and present.

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  1. Department of Neurobiology/Pharmacology, Neuroscience Institute, Morehouse School of Medicine, Moorehouse University, 720 Westview Drive SW, Atlanta, GA, 30310-1495, USA

    Robert Meller D.Phil.

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  1. Robert Meller D.Phil.
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Correspondence to Robert Meller D.Phil. .

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  1. , Departments of Neurosurgery, Washington University School of Medicine, South Kingshighway Boulevard, St. Louis, 63110, Missouri, USA

    Jeffrey M. Gidday

  2. , Department of Neurology, University of Miami Miller School of Med, Miami, 33136, Florida, USA

    Miguel A. Perez-Pinzon

  3. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Meller, R. (2013). Synaptic Signaling in Ischemic Tolerance. In: Gidday, J., Perez-Pinzon, M., Zhang, J. (eds) Innate Tolerance in the CNS. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9695-4_17

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