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Surgical Methods to Induce Brain Preconditioning

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Innate Tolerance in the CNS

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Surgical methods to induce preconditioning are among the most common techniques used to experimentally induce ischemic preconditioning. In effect, when someone approaches this field of research, the most intuitive method that comes into the researcher’s mind to induce preconditioning is to use a short subliminal occlusion of the artery that will undergo subsequent harmful occlusion. Despite the relatively simpleness of the idea, the definition of the surgical techniques that can be used in animals to induce brain ischemic preconditioning is not that easy. In this chapter, we will review the most relevant surgical methods used to induce brain preconditioning.

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Author information

Authors and Affiliations

  1. Division of Pharmacology, Department of Neuroscience, School of Medicine, “Federico II” University of Naples, Via Pansini, 5, 80131, Naples, Italy

    Giuseppe Pignataro M.D., Ph.D., Ornella Cuomo Ph.D. & Antonio Vinciguerra Ph.D. student

Authors
  1. Giuseppe Pignataro M.D., Ph.D.
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  2. Ornella Cuomo Ph.D.
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  3. Antonio Vinciguerra Ph.D. student
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Editor information

Editors and Affiliations

  1. , Departments of Neurosurgery, Washington University School of Medicine, South Kingshighway Boulevard, St. Louis, 63110, Missouri, USA

    Jeffrey M. Gidday

  2. , Department of Neurology, University of Miami Miller School of Med, Miami, 33136, Florida, USA

    Miguel A. Perez-Pinzon

  3. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Pignataro, G., Cuomo, O., Vinciguerra, A. (2013). Surgical Methods to Induce Brain Preconditioning. In: Gidday, J., Perez-Pinzon, M., Zhang, J. (eds) Innate Tolerance in the CNS. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9695-4_10

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  • DOI: https://doi.org/10.1007/978-1-4419-9695-4_10

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-9694-7

  • Online ISBN: 978-1-4419-9695-4

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