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Calcium Signaling at the Blood–Brain Barrier in Stroke

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Metal Ion in Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

The blood–brain barrier (BBB) is a critical player in the regulation of the brain’s microenvironment. In a number of pathological disease states, including Alzheimer’s disease, multiple sclerosis, and stroke, this barrier is disrupted, allowing free diffusion of molecules and water into the brain parenchyma. In stroke, the BBB loosens, and ions freely diffuse across the walls of the brain capillaries into the central nervous system. This is followed by passive movement of water, leading to edema formation which contributes to neuronal damage. Disruption of the BBB has been linked to a number of mechanisms, including increases in intracellular calcium and activation of calcium-sensitive signaling cascades. This review outlines some potential routes for hypoxia-stimulated calcium influx and explores some of the calcium signaling cascades and subsequent molecular events that have been linked to BBB disruption.

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Authors and Affiliations

  1. Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St, Houston, TX, 77030, USA

    Rachel C. Brown

  2. Institute for Pharmacological Sciences, King’s College London, Blood-Brain Barrier Group, Franklin Wilkins Building, London, SE1 9NH, UK

    Rachel C. Brown

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  1. Rachel C. Brown
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Correspondence to Rachel C. Brown .

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  1. , Department of Biomedical Sciences, Ohio University, 346 Irvine Hall, Athens, 45701, Ohio, USA

    Yang V. Li

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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© 2012 Springer Science+Business Media New York

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Brown, R.C. (2012). Calcium Signaling at the Blood–Brain Barrier in Stroke. In: Li, Y., Zhang, J. (eds) Metal Ion in Stroke. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9663-3_6

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