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Stroke Preconditioning to Identify Endogenous Protective or Regenerative Mechanisms

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Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Many neuroprotectants have shown effectiveness by reducing infarction and improving neurologic functions in animal models of stroke, but few of these neuroprotectants have been successful in clinical scenario. In clinical trials, pharmacological agents have shown to be either ineffective or have potential adverse effects. Consequently, efforts have been directed toward understanding and enhancing the endogenous protective mechanisms by which the brain protects itself against noxious stimuli in an attempt to recover from the damage encountered. Preconditioning-induced ischemic tolerance is an effective approach to understand how the brain protects itself. In this chapter, we summarize the development of preconditioning followed by discussion of various stimuli that can induce brain preconditioning and the downstream signaling pathways involved in preconditioning-induced protection. Specifically, we discuss the potential clinical application of preconditioning for brain injuries such as stroke.

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Authors and Affiliations

  1. Department of Hematology, Navy General Hospital, Fucheng Road, Beijng, China

    Liren Qian

  2. Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA

    Prativa Sherchan

  3. Department of Hematology, Navy General Hospital, Fucheng Road, Beijng, 100048, China

    Xuejun Sun

  4. Department of Diving Medicine, Second Military Medical University, Shanghai, 200433, China

    Xuejun Sun

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  1. Liren Qian
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  2. Prativa Sherchan
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  3. Xuejun Sun
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Correspondence to Xuejun Sun .

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Editors and Affiliations

  1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA

    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Qian, L., Sherchan, P., Sun, X. (2012). Stroke Preconditioning to Identify Endogenous Protective or Regenerative Mechanisms. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_16

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