Summary and Conclusion

Abstract

We have attempted to present a framework for translational evidence-based osteoimmunology and osteoimmunopathology. We have established the biological foundations of the emerging understanding of the interactions between the bone system and the immune system. We reviewed the cellular, molecular, and proteomic pathways that converge to bone metabolism on one hand, and cell-mediated immunity on the other. More importantly, we described and discussed the multiple cross-regulatory mechanisms through which osteology and immunology sustain each other, and on each other.