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Structure-Function Relationship of the Extracellular Calcium-Sensing Receptor

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Calcium-Sensing Receptor

Part of the book series: Endocrine updates ((ENDO,volume 19))

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Abstract

The extracellular calcium (Ca2+ o)-sensing receptor (CaR), originally cloned from bovine parathyroid, is a G protein-coupled receptor (GPCR) (1). The CaR is expressed on the plasma membrane of a variety of cell types, including those involved in maintaining systemic calcium homeostasis, such as parathyroid chief cells, renal cells, as well as thyroid C-cells, and those not participating in systemic calcium homeostasis, such as brain and breast cells (2). The CaR is well conserved across species (3–8). For instance, the amino acid sequences of CaRs from human, rat, and rabbit are more than 90% identical to that of the bovine CaR.

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  1. Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Mei Bai Ph.D.

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  1. Endocrine-Hypertension Division Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Naibedya Chattopadhyay  & Edward M. Brown  & 

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Bai, M. (2003). Structure-Function Relationship of the Extracellular Calcium-Sensing Receptor. In: Chattopadhyay, N., Brown, E.M. (eds) Calcium-Sensing Receptor. Endocrine updates, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9256-7_2

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