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Alginate Biosynthesis

  • Chapter
Pseudomonas

Abstract

Alginate was first isolated from marine algae in the 19th century, and was first identified from a bacterial source, namely mucoid Pseudomonas aeruginosa, in the 1960s75. Alginate is also synthesized by Azotobacter vinelandii as part of the encystment process54. Alginate is a simple unbranched polysaccharide that is composed of two kinds of uronic acid residues: β-D-mannuronic acid (M), and its C5 epimer, α-L-guluronic acid (G) (Figure 1A). Excellent reviews on alginate research have been offered by the late Peter Gacesa in 199046 and 199845. The pathogenesis of mucoid, alginate-producing P. aeruginosa in cystic fibrosis (CF) patients was also reviewed in 1996 by Govan and Deretic56. The following chapter presents highlights from these previous reviews and new studies that have recently been described.

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  1. Medical College of Virginia, Campus of Virginia Commonwealth University, Richmond, Virginia, USA

    Sumita Jain & Dennis E. Ohman

  2. McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA

    Sumita Jain & Dennis E. Ohman

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  1. Sumita Jain
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  1. CSIC, Granada, Spain

    Juan-Luis Ramos

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Jain, S., Ohman, D.E. (2004). Alginate Biosynthesis. In: Ramos, JL. (eds) Pseudomonas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9088-4_2

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