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Lipopolysaccharides of Pseudomonas aeruginosa

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Pseudomonas

Abstract

The lipopolysaccharide (LPS) of Pseudomonas aeruginosa is a major constituent of the outer leaflet of the outer membrane of the Gram-negative bacterial cell wall. Due to its surface location, LPS plays a critical role in the structural integrity of the outer membrane and in the interaction of the bacterium with its environment. In the human host, LPS shed by bacteria is usually bound by LPS-binding protein106, 178, and is transferred to the CD14 receptor198 on macrophages inducing the release of proinflammatory cytokines including tumor necrosis factor-α, interleukin 1 (IL-1), IL-6, IL-8 and IL-10115. In addition, it has been shown that LPS of bacteria interacts with Toll-like receptor 4 on host membranes and induces the release of cytokines147. Properly regulated release of these inflammatory mediators is part of innate immunity against bacterial infections. However, excessive stimulation of the immune systems by LPS can result in septic shock and even death115. Therefore, a better understanding of the biosynthesis of P. aeruginosa LPS will provide the means to develop methods to block the interactions between LPS and host receptors.

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Authors and Affiliations

  1. Canadian Bacterial Diseases Network Department of Microbiology, University of Guelph, Guelph, ON, N1G 2W1, Canada

    Joseph S. Lam, Mauricia Matewish & Karen K. H. Poon

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  1. Joseph S. Lam
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  2. Mauricia Matewish
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  1. CSIC, Granada, Spain

    Juan-Luis Ramos

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Lam, J.S., Matewish, M., Poon, K.K.H. (2004). Lipopolysaccharides of Pseudomonas aeruginosa . In: Ramos, JL. (eds) Pseudomonas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9088-4_1

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  • DOI: https://doi.org/10.1007/978-1-4419-9088-4_1

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