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Biological Model

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Advanced Abnormal Psychology

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Abstract

Within the biological models of behavior, there are various major themes about what determines or underlies both normal and abnormal behavior. The most widely accepted premise is that the nervous system is the center of control for all behavior. Therein lies the content of this chapter. What controls the development of the nervous system, and what elements combine to determine its state and function at any given time? To answer these questions, the following must be considered: (1) genetic determinants of the development of the nervous system, (2) how environmental factors interact with genetics to influence neural development; and (3) the dynamics of change in the developed nervous system.

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References

  • Akbarian, S., Kim, J. J., Potkin, S. G., Hagman, J. O., Tafazzoli, A., Bunney, W. E., Jr., & Jones, E. G. (1995). Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Archives of General Psychiatry, 52, 267–278.

    Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: Author.

    Google Scholar 

  • Andreasen, N. C, Rezai, K., Alliger, R., Swayze, V. W., II, Flaum, M., Kirchner, P., Cohen, G., & O’Leary, D. S. (1992). Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London. Archives of General Psychiatry, 49, 943–958.

    PubMed  Google Scholar 

  • Andreason, N. C. (1994). Changing concepts of schizophrenia and the ahistorical fallacy. American Journal of Psychiatry, 151, 1405–1407.

    Google Scholar 

  • Arriagada, P. V., Growdon, J. H., Hedley-Whyte, T., and Human, B. T. (1992). Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology, 42, 631–639.

    PubMed  Google Scholar 

  • Barlow, D. H. (1988). Anxiety and its disorders: The nature and treatment of anxiety and panic. New York: Guilford.

    Google Scholar 

  • Baron, M, Risch, N., Hamburger, R., Mandel, B., Kushner, S., Newman, M., Drumer, D., Belmaker, R. H. (1987). Genetic linkage between X-chromosome markers and bipolar affective illness. Nature, 326, 289–292.

    PubMed  Google Scholar 

  • Benes, F. M. (1993). The relationship between structural brain imaging and histopathologic findings in schizophrenia research. Harvard Review of Psychiatry, 1, 100–109.

    PubMed  Google Scholar 

  • Berman, K. F., & Weinberger, D. R. (1990). The prefrontal cortex in schizophrenia and other neuropsychiatrie diseases: In vivo physiological correlates of cognitive deficits. Progress in Brain Research, 85, 521–536.

    PubMed  Google Scholar 

  • Bierer, L. M., Hof, P. R., Purohi, D. P., Carlin, L., Schmeider, J., Davis, K. L., Perl, D. P. (1995). Neocortical neurofibrillary tangle correlate with dementia severity in Alzheimer’s disease. Archives of Neurology, 52, 81–88.

    PubMed  Google Scholar 

  • Bindra, D. A. (1970). Emotion and behavior theory: Current research in historical perspective. In P. Black (Ed.), Physiological correlates of emotion (pp. 3–20). New York: Academic.

    Google Scholar 

  • Bird, T. D., Lampe, T. H., Wijsman, E. M., & Schellenberg, G. D. (1998). Familial Alzheimer’s disease: genetic studies. In M. F. Folstein (Ed.), Neurobiology of primary dementia. Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Breier, A., Su, T. P., Saunders, R., Carson, R. E., Kolachana, B. S., DeBartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C, & Pickar, D. (1997). Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission method. Proceedings of the National Academy of Sciences USA, 94, 2569–2574.

    Google Scholar 

  • Breiter, H. C, Rauch, S. L., Kwong, K. K., Baker, J. R., Weisskoff, R. M., Kennedy, D. N., Kendrick, A. D., Davis, T. L., Jiang, A. P., Cohen, M. S., Stern, C. E., Belliveau, J. W, Baer, L., O’Sullivan, R. L., Savage, C. R., Jenike, M. A., & Rosen, B. R. (1996). Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder. Archives of General Psychiatry, 53, 595–606.

    PubMed  Google Scholar 

  • Brown, R. P., Kocsis, J. H., & Frazer A. (1985). Serum melatonin in affective disorders. American Journal of Psychiatry, 142, 811–816.

    PubMed  Google Scholar 

  • Bunney, W. E., Jr., & Davis, J. M. (1965). Norepinephrine in depressive reactions: A review. Archives of General Psychiatry, 13, 483–494.

    PubMed  Google Scholar 

  • Cannon, W. B. (1920). Bodily changes in pain, fear, and rage. New York: Appleton.

    Google Scholar 

  • Cardoret, R. J., & Winokur, G. (1975). X-linkage in manic-depressive illness. Annual Review of Medicine, 26, 21–25.

    Google Scholar 

  • Cartwright, R. D., & Wood, E. (1991). Adjustment disorders of sleep: The sleep effects of a major stressful event and its resolution. Psychiatry Research, 39, 199–209.

    PubMed  Google Scholar 

  • Cassens, G., Wolfe, L., & Zola, M. (1990). The neuropsychology of depression. Journal of Neuropsychiatry and Clinical Neurosciences, 2, 202–213.

    PubMed  Google Scholar 

  • Cichon, S., Noethen, N. M, Catalano, M., Di Bella, D., et al. (1995). Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene. Psychiatric Genetics, 5(3), 97–103.

    PubMed  Google Scholar 

  • Conrad, A. J., Abebe, T., Austin, R., Forsythe, S., & Scheibel, A. B. (1991). Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Archives of General Psychiatry, 48, 413–417.

    PubMed  Google Scholar 

  • Crow, T. J. (1991). The search of the psychosis gene. British Journal of Psychiatry, 158, 611–614.

    PubMed  Google Scholar 

  • Crow, T. J., Delisi, L. E., Lofthouse, R., Poulter, M., Lehner, T., Bass, N., Shah, T., Walsh, C, Boccio-Smith, A., & Shields, G. (1994). An examination of linkage of schizophrenia and schizoaffective disorder to the pseudoauto-somal region (Xp22.3). British Journal of Psychiatry, 164, 159–164.

    PubMed  Google Scholar 

  • Curtis, G. C, Nesse, R., Buxton, M., & Lippman, D. (1979). Plasma growth hormone: Effect of anxiety during flooding in vivo. American Journal of Psychiatry, 136(4-A), 410–414.

    PubMed  Google Scholar 

  • Curtis, G. C, Nesse, R. M, Buxton, M, & Lippman, D. (1979). Plasma growth hormone: Effect of anxiety during flooding in vivo. American Journal of Psychiatry, 136, 410–414.

    PubMed  Google Scholar 

  • Dalack, G. W., Glassman, A. H., Rivelli S., Covey, L., & Stetner, F. (1995). Mood, major depression, and fluoxetine response in cigarette smokers. American Journal of Psychiatry, 752(3), 398–403.

    Google Scholar 

  • Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991). Dopamine in schizophrenia: A review and reconceptualization. American Journal of Psychiatry, 148, 1474–1486.

    PubMed  Google Scholar 

  • Dickson, D. W, Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D, Davies, P., Yen, S. H., & Arson, M. K. (1992). Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiology of Aging, 13, 179–189.

    PubMed  Google Scholar 

  • Dilsaver, S. C. (1986). Cholinergic mechanisms in depression. Brain Research Reviews, 11(3), 285–316.

    Google Scholar 

  • Duman, R. S. (1998). Novel therapeutic approaches beyond the serotonin receptor. Biological Psychiatry, 44(5), 324–335.

    PubMed  Google Scholar 

  • Egeland, J. A., Gerhard, D. S., Pauls, D. L., Sussex, J. N., et. al. (1987). Bipolar affective disorder linked to DNA markers on chromosome 11. Nature, 325(6101), 783–787.

    PubMed  Google Scholar 

  • Ehlers, A., Margraf, J., Roth, W. T., Taylor, C. B., Maddock, R. J., Sheik, J., Kobell, M. L., McClenahan, K. L., Gossard, D., Blowers, G. H., Agras, W. S., & Kopell, B. S. (1986). Lactate infusions and panic attacks: Do patients and controls respond differently? Psychiatry Research, 17, 295–308.

    PubMed  Google Scholar 

  • Forstl, H., & Levy, R. (1991). Foreword to the translation of“On certain peculiar diseases of old age” (by Alois Alzheimer). History of Psychiatry, ii, 71–74.

    Google Scholar 

  • Goedert, M., Wischik, C. M, Crowther, R. A., Walker, J. E., & Klug, A. (1988). Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer’s disease: Identification as the microtubule-associated protein tau. Proceedings of the National Academy of Sciences USA, 85, 4051–4055.

    Google Scholar 

  • Goldman-Rakic, P. S. (1996). Dissolution of cerebral cortical mechanisms in subjects with schizophrenia. In S. J. Watson (Ed.), Biology of schizophrenia and affective disease (pp. 113–128). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Golomb, J., deLeon, M. J., George, A. E., Kluger, A., Convit, A., Rusinek, H., deSanti, S., Litt, A., Foo, S. H., & Ferris, S. H. (1994). Hippocampal atrophy correlates with severe cognitive impairment in elderly patients with suspected normal pressure hydrocephalus. Journal of Neurology, Neurosurgery and Psychiatry, 57, 590–593.

    Google Scholar 

  • Gooding, D., & lacono, W. (1995). Schizophrenia through the lens of a developmental psychopathology perspective. In Developmental psychopathology, Vol. 2: Risk, disorder, and adaptation. Wiley Series on Personality Processes (pp. 535–580). New York: Wiley.

    Google Scholar 

  • Gottesman, I. L. (1995). Schizophrenia genes: The origins of madness. New York: Freeman.

    Google Scholar 

  • Grahme-Smith, D. G., Green, A. R., & Costain, D. W. (1978). Mechanism of the anti-depressant action of electroconvulsive therapy. Lancet, 1, 254–256.

    Google Scholar 

  • Green, A. R. (1978). ECT—How does it work? Trends in Neuroscience, 1, 53–54.

    Google Scholar 

  • Haass, C, Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C, Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., & Selkoe, D. (1992). Amyloid beta peptide is produced by cultured cells during abnormal metabolism. Nature, 359, 322–325.

    PubMed  Google Scholar 

  • Hall, M. H., Dahl, R. E., Dew, M. A., & Reynolds, C. F. (1995). Sleep patterns following major negative life events. Directions in Psychiatry, 15, 1–10.

    Google Scholar 

  • Hyde, T. M., & Weinberger, D. R. (1990). The brain in schizophrenia. Seminars in Neurology, 10, 276–286.

    PubMed  Google Scholar 

  • Imamura, M., & Prasad, C. (1998). Increased GABA-gated chloride ion influx in the hypothalamus of low anxiety rats. Physiological Behavior, 64(3), 415–417.

    Google Scholar 

  • Jablensky, A., Sartorius, N., Ernberg, G., Anker, M., Körten, A., Cooper, J. E., Day, R., & Bertelsen, A. (1992). Schizophrenia: Manifestations, incidence, and course in different cultures. Psychological Medicine, Monograph Supplement, 20.

    Google Scholar 

  • James, W. (1884). What is emotion? Mind, 9(Series I), 188–204.

    Google Scholar 

  • Kagan, J. (1997). Temperament and the reactions to unfamiliarity. Child Development, 68, 139–143.

    PubMed  Google Scholar 

  • Kalin, N. H., Dawson, G., Traiot, P., Shelton, S., Barksdale, C, Weiler, S., & Thienemann, M. (1987). Function of the adrenal cortex in patients with major depression. Psychiatry Research, 22, 117–125.

    PubMed  Google Scholar 

  • Kemali, D., Galderisi, M. S., Ariano, M. G., Cesarelli, M., Milici, N., Salvati, A., Valente, A., & Volpe, M. (1985). Clinical and neuropsychological correlates of cerebral ventricular enlargement in schizophrenia. Journal of Psychiatric Research, 19, 587–596.

    PubMed  Google Scholar 

  • Kety, S.S. (1983). Mental illness in the biological and adoptive families of schizophrenic adoptees: Findings relevant to genetic and environmental factors in etiology. American Journal of Psychiatry, 140, 720–727.

    PubMed  Google Scholar 

  • Kety, S. S., Wender, P. H., Jacobsen, B., Ingraham, L. J., Jansson, L., Faber, B., & Kinney, D. K. (1994). Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen study in the rest of Denmark. Archives of General Psychiatry, 51, 442–455.

    PubMed  Google Scholar 

  • Kovelman, J. A., & Scheibel, A. B. (1984). A neurohistological correlate of schizophrenia. Biological Psychiatry, 19, 1601.

    PubMed  Google Scholar 

  • Lacey, J. I., & Lacey, B. C. (1970). Some autonomie-central nervous system interrelationships. In P. Black (Ed.), Physiological correlates of emotion. New York: Academic.

    Google Scholar 

  • Lampe, T. H., Bird, T. D., Nochlin, D., Nemens, E., Risse, S. C, Sumi, S. M., Koerker, R., Leaird, B., Wier, M., & Raskind, M. A. (1994). Phenotype of chromosome 14-linked familial Alzheimer’s disease in a large kindred. Annals of Neurology, 36, 368–378.

    PubMed  Google Scholar 

  • Lang, P. J. (1995). The emotion probe: Studies of motivation and attention. American Psychologist, 50(5), 372–385.

    PubMed  Google Scholar 

  • Levy-Lahad, E., Wijsman, E. M., Nemens, E., Anderson, L., Goddard, K. A., Weber, J. L., Bird, T. D., & Schellenberg, G. D. (1995). A familial Alzheimer’s disease locus on chromosome 1. Science, 269, 970–973.

    PubMed  Google Scholar 

  • Loosen, P. T. (1985). The TRH-induced TSH response in psychiatric patients: A possible neuroendocrine marker. Psychoneuroendocrinology, 10, 237–260.

    PubMed  Google Scholar 

  • Loosen, P. T., & Prange A. J., Jr. (1982). Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: A review. American Journal of Psychiatry, 139, 405–416.

    PubMed  Google Scholar 

  • Machon, R. A., Mednick, S. A., & Huttunen, M. O. (1997). Adult major affective disorder after prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 54, 322–328.

    PubMed  Google Scholar 

  • Mann, J. J., & Stanley, M. (Eds.). (1986). Psychobiology of suicidal behavior. Annals of the New York Academy of Science, 487, 1–357.

    Google Scholar 

  • Mann, J. J., & Kupfer, D. J. (Eds.). (1993). Biology of depressive disorders, Part A: A systems perspective. In The depressive illness (p. 272). New York: Plenum.

    Google Scholar 

  • Marx, J. L. (1985). “Anxiety peptide” found in brain. Science, 227, 934.

    PubMed  Google Scholar 

  • Mednick, S. A., Huttunen, M. O., & Machon, R. A. (1994). Prenatal influenza infections and adult schizophrenia. Schizophrenia Bulletin, 20, 263–267.

    PubMed  Google Scholar 

  • Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., van Belle, G., & Berg, L. (1991). The consortium to establish a registry for Alzheimer’s disease. Neurology, 41, 479–486.

    PubMed  Google Scholar 

  • Moldin, S. O., Reich, T., & Rice, J. P. (1991). Current perspectives on the genetics of unipolar depression. Behavior Genetics, 21, 211–242.

    PubMed  Google Scholar 

  • Morris, R. G. (1996). The cognitive neuropsychology of Alzheimer-type dementia. Oxford, England: Oxford University Press.

    Google Scholar 

  • Nemeroff, C. B. (1996). The corticotropin-releasing factor (CRF) hypothesis of depression: New findings and new directions. Molecular Psychiatry, 1(4), 336–342.

    PubMed  Google Scholar 

  • Ockel, M., Lewin, G. R., & Barde, Y.A. (1996). In vivo effects of neurotrophin-3 during sensory neurogenesis. Development, 122(1), 301–307.

    PubMed  Google Scholar 

  • Oppenheim, R. W. (1991). Cell death during development of the nervous system. Annual Review of Neuroscience, 14, 453–501.

    PubMed  Google Scholar 

  • Owens, M. J., & Nemeroff, C. B. (1994). The role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter. Clinical Chemistry, 40, 288–295.

    PubMed  Google Scholar 

  • Redmond, D. E. (1979). New and old evidence for the involvement of a brain norepinephrine system in anxiety. In W. E. Fann, I. Karacan, & A. Pokorny (Eds.), Phenomenology and the treatment of anxiety (pp. 152–203). New York: SP Medical and Scientific Books.

    Google Scholar 

  • Reynolds, C. F., & Kupfer, D. J. (1987). Sleep research in affective illness: State of the art circa. Sleep, 10(3), 199–215.

    PubMed  Google Scholar 

  • Rocca, W. A., Hofman, A., Brayne, C, Breteler, M. M., Clarke, M., Copeland, J. R., Dartigues, J. F., Engedal, K., Hagneil, O., Heeren, T. J., et al. (1991). The prevalence of vascular dementia in Europe: Facts and fragments from 1980-1990 studies. Annals of Neurology, 30, 817–824.

    PubMed  Google Scholar 

  • Rosenzweig, M. R., Leiman, A. L., & Breedlove, S. M. (1999). Biological psychology: An introduction to behavioral, cognitive, and clinical neuroscience. Sunderland, MA: Sinaur Associates.

    Google Scholar 

  • Roses, A. D. (1994). Apolipoprotein E affects the rate of Alzheimer disease expression: J-Amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. Journal of Neuwpathology and Experimental Neurology, 53, 429–437.

    Google Scholar 

  • Rubin, R. T. (1989). Pharmacoendocrinology of major depression. European Archives of Psychiatry and Neurological Sciences, 238(5-6), 259–267.

    PubMed  Google Scholar 

  • Rubin, R. T., Ananth, J., Villanueva-Meyer, J., Trajmar, P. G., & Mena, I. (1995). Regional 133 Xenon cerebral blood flow and cerebral 99m Tc-HM-PAO uptake in patients with obsessive-compulsive disorder before and during treatment. Biological Psychiatry, 38, 429–437.

    PubMed  Google Scholar 

  • Rubin, R. T., Poland, R. E., Lesser, I. M., & Martin, D. J. (1989). Neuroendocrine aspects of primary endogenous depression: V. Serum prolactin measures in patients and matched control subjects. Biological Psychiatry, 25(1), 4–21.

    PubMed  Google Scholar 

  • Saeb, J. P., Jagust, W. J., Wong, S. T. S., et al. (1988). Quantitative NMR measurements of hippocampal atrophy in Alzheimer’s disease. Magnetic Resonance Imaging, 8, 200–208.

    Google Scholar 

  • Schildkraut, J. J. (1965). The catecholamine hypothesis of affective disorders: A review of supporting evidence. American Journal of Psychiatry, 139, 471–475.

    Google Scholar 

  • Schildkraut, J. J., & Kety, S. S. (1967). Biogenic amines and emotion. Science, 156, 21–30.

    PubMed  Google Scholar 

  • Schwartz, M. W., Peskind, E., Raskind, M., Boyoko, E. J., & Porte, D. (1996). Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nature Medicine, 2, 589–593.

    PubMed  Google Scholar 

  • Seeman, P., Guan, H. C, & Van Tol, H. H. (1993). Dopamine D4 receptors elevated in schizophrenia. Nature, 365, 441–445.

    PubMed  Google Scholar 

  • Selye, H. (1978). The stress of life. New York: McGraw-Hill.

    Google Scholar 

  • Siever, L. J., & Uhde, T. W. (1984). New studies and perspectives on the noradrenergic receptor system in depression: Effects of the alpha-2 adrenergic agonist clonidine. Biological Psychiatry, 142, 184–187.

    Google Scholar 

  • Shields, J. (1962). Monozygotic twins brought up apart and brought up together. London: Oxford University Press.

    Google Scholar 

  • Siever, L. J., & Davis, K. L. (1985). Overview: Toward a dysregulation hypothesis of depression. American Journal of Psychiatry, 142(9), 1017–1031.

    PubMed  Google Scholar 

  • Slater, B., & Shields, J. (1969). Genetical aspects of anxiety. In British Journal of Psychiatry Special Publication No. 3: Studies of Anxiety. Ashford, Kent: Headly Bros.

    Google Scholar 

  • Slater, E., & Roth, M. (1960). Clinical Psychiatry, 1st ed. London: Bailliere, Tindall, and Cassel.

    Google Scholar 

  • Smith, R., Cubis J., Brinsmead, M., Lewin, T., Singh, B., Ownes, P., Chan, E. C, Hall, C, Adler, R., Lovelock, M., Hurt, D., Rowley, M., & Nolan, M. (1990). Mood changes, obstetric experiences and alterations in plasma Cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium. Journal of Psychosomatic Research, 34(1), 53–69.

    PubMed  Google Scholar 

  • St. George-Hyslop, P. H. (1993). Recent advances in the molecular genetics of Alzheimer’s disease. Neuroscience, 1, 171–175.

    Google Scholar 

  • St. George-Hyslop, P. H., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Nee, L., Watkins, P. C, Meyers, R. H., Feldman, R. G., Pollen, D., Drachman, D., Growdon, J., Bruni, A., Jean-Francois, F., Salmon, D., Frommelt, P., Amaducci, L., Sorbi, S., Piacentini, S., Stewart, G. D., Hobbs, W. J., Conneally, M., & Gusella, J. F. (1987). The genetic defect causing familial Alzheimer’s disease maps on chromosome 21. Science, 235, 885–890.

    PubMed  Google Scholar 

  • Stokes, P. E. (1995). The potential role of excessive Cortisol induced by HPA hyperfunction in the pathogenesis of depression. European Neuropsychopharmacology, 5(Suppl.), 77–82.

    PubMed  Google Scholar 

  • Swedo, S. E., Leonard, H. L., Kraesi, M. J. P., Rettew, D. C, Listwak, S. J., Berrettini, W., Stipetic, M., Hamburger, S., Gold, P. W., Potter, W. Z., & Rapoport, J. L. (1992). CSF neurochemistry in children and adolescents with obsessive-compulsive disorder. Archives of General Psychiatry, 49, 29–36.

    PubMed  Google Scholar 

  • Thinakaran, G., Regard, J. B., Bouton, C. M., Harris, C. L., Price, D. L., Borchelt, D. R., & Sisodia, S. S. (1998). Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiology of Disease, 4, 438–453.

    PubMed  Google Scholar 

  • Torrey, E. F., Bowler, A. E., Taylor, E. H., & Gottesman, 1.1. (1994). Schizophrenia and manic depressive disorder. New York: Basic Books.

    Google Scholar 

  • Trimble, M. R. (1996). Schizophrenia. In Biological psychiatry (pp. 183–225). New York: Wiley.

    Google Scholar 

  • Tsuang, M. T. (1993). Genotypes, phenotypes, and the brain. British Journal of Psychiatry, 163, 299–307.

    PubMed  Google Scholar 

  • Ungerstedt, U. (1979). Central dopamine mechanisms and unconditioned behaviour. In A. S. Horn, J. Korf, & B. H. C. Westerink (Eds.), The neurobiology of dopamine (pp. 577–596). New York: Academic.

    Google Scholar 

  • Van Bockstaele, E. J. (1998). Morphological substrates underlying opoiod, epinephrine and gamma-aminobutyric acid inhibitory actions in rat locus coeruleus. Brain Research Bulletin, 47, 1–15.

    PubMed  Google Scholar 

  • Wainer, B. H., Steininger, T. L., Roback, J. D., Burke-Watson, M. A., Mufson, E. J., & Kordower, J. (1993). Ascending cholinergic pathways: Functional organization and implications for disease models. Progress in Brain Research, 98, 9–30.

    PubMed  Google Scholar 

  • Watson, S. J. (1996). Biology of schizophrenia and affective disease. Washington, D.C.: American Psychiatric Press.

    Google Scholar 

  • Weinberger, D. R., Aloia, M. S., Goldberg, T. E., & Berman, K. F. (1994). The frontal lobes and schizophrenia. Journal of' Neuropsychiatry and Clinical Neurosciences, 6, 419–427.

    Google Scholar 

  • Wible, C. C, Shenton, M. E., Hokama, H., Kikinis, R., Jolesz, F. A., Metcalf, D., & McCarley, R. W. (1995). Prefrontal cortex and schizophrenia. A quantitative magnetic resonance imaging study. Archives of General Psychiatry, 52, 279–288.

    PubMed  Google Scholar 

  • Wilson, J. (1988). Anxiety disorders: Current treatments and controversies. Paper presented at Annual Convention of the American Psychological Association, Atlanta, GA, August, 1988.

    Google Scholar 

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  1. Center for Psychological Studies, Nova Southeastern University, Fort Lauderdale, 33314, Florida, USA

    Doil D. Montgomery & Pamela M. Planthara

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  1. Pacific University, Forest Grove, Oregon, USA

    Michel Hersen

  2. Nova Southeastern University, Fort Lauderdale, Florida, USA

    Vincent B. Van Hasselt

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Montgomery, D.D., Planthara, P.M. (2001). Biological Model. In: Hersen, M., Van Hasselt, V.B. (eds) Advanced Abnormal Psychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8497-5_6

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