Abstract
An increasing collection of chemical compounds is now prepared by MultiComponent Reactions (MCRs), since a synthesis by a MCR can be accomplished just by mixing their educts and their yields are usually much higher than by the multistep syntheses that correspond to sequences of many steps. The latter require much preparative work and their yield decreases with each step. With the exception of Passerini’s work, in the first century of the MCRs and chemistry of the isocyanides were not combined. These two parts of chemistry were combined in 1959 when the four component reaction of the isocyanides (U-4CR) was introduced.1 In the usual chemistry, their MCRs are less used than its normal reactions, whereas in the chemistry of the isocyanides more MCRs and their libraries are carried out than those of one or two components.
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Ugi, I., Roβ, G., Burdack, C. (2003). The Chemical Progress of Multicomponent Reactions. In: Geckeler, K.E. (eds) Advanced Macromolecular and Supramolecular Materials and Processes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8495-1_18
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