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Hedgehog Signaling in Mammary Gland Development and Breast Cancer

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Hedgehog signaling activation in human cancer and its clinical implications

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Abstract

The Hedgehog signal transduction network is an essential regulator of metazoan embryonic development and functions in tissue homeostasis in the adult. In the mammary gland, this network mediates epithelial–stromal interactions regulating branching morphogenesis and histoarchitecture of mammary ducts, and may control alveolar differentiation. Inappropriate activation of the Hedgehog network is associated with a wide variety of cancers, including breast. Genetic evidence in mice, as well as molecular biological studies in human cells, demonstrated that activated signaling can lead to mammary hyperplasia and, in some cases, tumor formation. However, the mechanism(s) by which Hedgehog signaling regulates normal gland development, and exactly how activated Hedgehog signaling contributes to development or progression of breast cancer remain unclear. Because evidence of inappropriate activation of Hedgehog signaling is observed in some breast cancers, and network activity is associated with breast cancer cell self-renewal, the Hedgehog network has become a leading candidate for the development of targeted therapeutics.

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Authors and Affiliations

  1. The Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, BCM600, Room N1210, Houston, TX, 77030, USA

    Michael T. Lewis

  2. Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, One Baylor Plaza, BCM600, Room N1210, Houston, TX, 77030, USA

    Michael T. Lewis

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  1. Adriana P. Visbal
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  1. University of Texas Medical Branch, Galveston, 77555, Texas, USA

    Jingwu Xie

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Visbal, A.P., Lewis, M.T. (2011). Hedgehog Signaling in Mammary Gland Development and Breast Cancer. In: Xie, J. (eds) Hedgehog signaling activation in human cancer and its clinical implications. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8435-7_9

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