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Signaling Cross-Talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer

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Hedgehog signaling activation in human cancer and its clinical implications

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Abstract

Oncogenic transformation is the result of a complex process that involves multiple steps of genetic and cellular alterations, most notably the activation of oncogenes and the inactivation of tumor suppressor genes. Great advances have been made in identifying genetic alterations associated with various human cancers in recent years. The discovery of signaling cross-talk between KRAS and Hedgehog signaling, the two universally dysregulated pathways in pancreatic cancer, provides new insights into understanding the mechanism of pancreatic tumorigenesis and potential novel therapeutic strategy for treating this deadly disease.

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  1. Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0615, USA

    Xiaodong Cheng

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Correspondence to Xiaodong Cheng .

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  1. University of Texas Medical Branch, Galveston, 77555, Texas, USA

    Jingwu Xie

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Cheng, X. (2011). Signaling Cross-Talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer. In: Xie, J. (eds) Hedgehog signaling activation in human cancer and its clinical implications. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8435-7_5

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