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Liposomes and Polymers in Folate-Targeted Cancer Therapeutics

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Targeted Drug Strategies for Cancer and Inflammation

Abstract

In this chapter, we will address the therapeutic potential of targeting liposomes and polymers to the folate receptor for delivery of anticancer drugs and review the experimental data in this field. By exploiting the pharmacologic attributes of liposomes and polymers together with their cellular internalization by folate receptor-mediated endocytosis, these systems should allow for improved selectivity and control of drug delivery to folate receptor expressing cancers. Particularly, extension of circulation time and enhanced deposition in tumors coupled with reduced toxicity of liposome- and polymer-associated drugs are important assets of the nanomedicine platform when compared to free drugs or low-molecular weight conjugates. In addition, the high drug:ligand ratio of liposomes and some polymers enable the delivery of a high drug payload per ligand–receptor interaction. However these systems have also some in vivo limitations that will be discussed. It remains unclear whether folate-targeted nanomedicines can provide a significant added value in clinical applications vis-à-vis folate-targeted drug conjugates.

The online version of the original chapter can be found at http://dx.doi.org/10.1007/978-1-4419-8417-3_11

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-1-4419-8417-3_12

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Notes

  1. 1.

     Stealth is a registered trademark of Alza Corp., Mountain View, CA.

  2. 2.

     Actively targeted carriers may also be referred to simply as targeted carriers.

  3. 3.

     Formulation with 0.5% ligand-to-phospholipid molar ratio.

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Authors and Affiliations

  1. Shaare Zedek Medical Center, Oncology Institute, Jerusalem, Israel

    Alberto Gabizon

  2. Hebrew University–School of Medicine, Jerusalem, Israel

    Alberto Gabizon & Hilary Shmeeda

  3. Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Hemda Baabur-Cohen & Ronit Satchi-Fainaro

Authors
  1. Alberto Gabizon
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  2. Hilary Shmeeda
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  3. Hemda Baabur-Cohen
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  4. Ronit Satchi-Fainaro
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Corresponding author

Correspondence to Alberto Gabizon .

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Editors and Affiliations

  1. Section of Medicine, Institute of Cancer Research, Cotswold Road 15, Sutton, SM2 5NG, United Kingdom

    Ann L. Jackman

  2. Endocyte Inc., Kent Avenue 3000, West Lafayette, 47906, Indiana, USA

    Christopher P. Leamon

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Gabizon, A., Shmeeda, H., Baabur-Cohen, H., Satchi-Fainaro, R. (2011). Liposomes and Polymers in Folate-Targeted Cancer Therapeutics. In: Jackman, A., Leamon, C. (eds) Targeted Drug Strategies for Cancer and Inflammation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8417-3_11

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