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Histamine in Allergic Rhinitis

  • Chapter
Histamine in Inflammation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 709))

Abstract

Histamine plays a major role in allergic rhinitis. In susceptible individuals, allergen induces nasal mast cell degranulation and the release of histamine into the nasal mucosa. Histamine has been detected after controlled challenges with allergen and, when administered into the nasal cavity, elicits signs and symptoms similar to those elicited by allergen. All four histamine receptors have been demonstrated in the nasal mucosa. The role of the four histamine receptors in the pathophysiology of allergic rhinitis are discussed.

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, Florida, 33612, USA

    Thomas Taylor-Clark

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Correspondence to Thomas Taylor-Clark .

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  1. Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, California, USA

    Robin L. Thurmond PhD

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Taylor-Clark, T. (2010). Histamine in Allergic Rhinitis. In: Thurmond, R.L. (eds) Histamine in Inflammation. Advances in Experimental Medicine and Biology, vol 709. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8056-4_4

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