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Essential Fatty Acids and Atopic Dermatitis

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References

  • Arikawa J, Ishibashi M, Kawashima M, et al. Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus. J Invest Dermatol. 2002;119:433–9.

    Article  PubMed  CAS  Google Scholar 

  • Bieber T. Atopic dermatitis. N Engl J Med. 2008;358:1483–94.

    Article  PubMed  CAS  Google Scholar 

  • Bleck O, Abeck D, Ring J, et al. Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of non-lesional skin of atopic eczema. J Invest Dermatol. 1999;113:894–900.

    Article  PubMed  CAS  Google Scholar 

  • Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758:2080–95.

    Article  PubMed  CAS  Google Scholar 

  • Bouwstra JA, Gooris GS, Dubbelaar FE, et al. Role of ceramide 1 in the molecular organization of the stratum corneum lipids. J Lipid Res. 1998;39:186–96.

    PubMed  CAS  Google Scholar 

  • Brod J, Traitler H, Studer A, et al. Evolution of lipid composition in skin treated with blackcurrant seed oil. Int J Cosmet Sci. 1988;10:149–59.

    Article  PubMed  CAS  Google Scholar 

  • Brosche T, Platt D. Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people. Arch Gerontol Geriatr. 2000;30:139–50.

    Article  PubMed  CAS  Google Scholar 

  • Brown WR, Hansen AE. Atachidonic acid and linoleic acid of the serum in normal and eczematous human subjects. Proc Soc Exp Biol Med. 1937;36:113–6.

    CAS  Google Scholar 

  • Brown SJ, Irvine AD. Atopic eczema and the filaggrin story. Semin Cutan Med Surg. 2008;27:128–37.

    Article  PubMed  CAS  Google Scholar 

  • Burr GO, Burr MM. A new deficiency disease produced by the rigid exclusion of fat from the diet. J Biol Chem. 1929;82:345–67.

    CAS  Google Scholar 

  • Burr GO, Burr MM. On the nature and role of the fatty acids essential in nutrition. J Biol Chem. 1930;86:587–621.

    CAS  Google Scholar 

  • Callard RE, Harper JI. The skin barrier, atopic dermatitis and allergy: a role for langerhans cells? Trends Immunol. 2007;28:294–8.

    Article  PubMed  CAS  Google Scholar 

  • Callaway J, Schwab U, Harvima I, et al. Efficacy of dietary hempseed oil in patients with atopic dermatitis. J Dermatolog Treat. 2005;16:87–94.

    Article  PubMed  CAS  Google Scholar 

  • Cameron DJ, Tong Z, Yang Z, et al. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int J Biol Sci. 2007;3:111–9.

    PubMed  CAS  Google Scholar 

  • Chung S, Kong S, Seong K, et al. Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. J Nutr. 2002;132:3090–7.

    PubMed  CAS  Google Scholar 

  • Colarow L. Quantification of ceramides with essential fatty acids moieties in the human skin surface and blood plasma lipids. J Planar Chromatogr. 1990;3:126–32.

    CAS  Google Scholar 

  • Conti A, Rogers J, Verdejo P, et al. Seasonal influences on stratum corneum ceramide 1 fatty acids and the influence of topical essential fatty acids. Int J Cosmet Sci. 1996;18:1–12.

    Article  PubMed  CAS  Google Scholar 

  • Cork MJ, Danby S. Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009;18:872. 4, 6–7.

    PubMed  Google Scholar 

  • Cork MJ, Robinson DA, Vasilopoulos Y, et al. New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene environment interactions. J Allergy Clin Immunol. 2006;118:3–21.

    Article  PubMed  CAS  Google Scholar 

  • Cork MJ, Danby SG, Vasilopoulos Y, et al. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009;129:1892–908.

    Article  PubMed  CAS  Google Scholar 

  • Darmstadt GL, Mao-Qiang M, Chi E, et al. Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries. Acta Paediatr. 2002;91:546–54.

    Article  PubMed  CAS  Google Scholar 

  • De Pascale MC, Bassi AM, Patrone V, et al. Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes. Arch Biochem Biophys. 2006;447:97–106.

    Article  PubMed  CAS  Google Scholar 

  • Descargues P, Deraison C, Prost C, et al. Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome. J Invest Dermatol. 2006;126:1622–32.

    Article  PubMed  CAS  Google Scholar 

  • Di Nardo A, Wertz P, Giannetti A, et al. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol. 1998;78:27–30.

    Article  PubMed  Google Scholar 

  • Elias PM, Steinhoff M. “Outside-to-inside” (and now back to “outside”) pathogenic mechanisms in atopic dermatitis. J Invest Dermatol. 2008;128:1067–70.

    Article  PubMed  CAS  Google Scholar 

  • Elias PM, Wood LC, Feingold KR. Epidermal pathogenesis of inflammatory dermatoses. Am J Contact Dermat. 1999;10:119–26.

    Article  PubMed  CAS  Google Scholar 

  • Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol. 2008;121:1337–43.

    Article  PubMed  CAS  Google Scholar 

  • Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr. 1998;128:1411–4.

    PubMed  CAS  Google Scholar 

  • Fartasch M, Bassukas ID, Diepgen TL. Disturbed extruding mechanism of lamellar bodies in dry non-eczematous skin of atopics. Br J Dermatol. 1992;127:221–7.

    Article  PubMed  CAS  Google Scholar 

  • Farwanah H, Raith K, Neubert RH, et al. Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin. Arch Dermatol Res. 2005;296:514–21.

    Article  PubMed  CAS  Google Scholar 

  • Foster RH, Hardy G, Alany RG. Borage oil in the treatment of atopic dermatitis. Nutrition. 2010;26:708–18.

    Article  PubMed  CAS  Google Scholar 

  • Fulmer AW, Kramer GJ. Stratum corneum lipid abnormalities in surfactant-induced dry scaly skin. J Invest Dermatol. 1986;86:598–602.

    Article  PubMed  CAS  Google Scholar 

  • Galli E, Picardo M, Chini L, et al. Analysis of polyunsaturated fatty acids in newborn sera: a screening tool for atopic disease? Br J Dermatol. 1994;130:752–6.

    Article  PubMed  CAS  Google Scholar 

  • Gehring W, Bopp R, Rippke F, et al. Effect of topically applied evening primrose oil on epidermal barrier function in atopic dermatitis as a function of vehicle. Arzneimittelforschung. 1999;49:635–42.

    PubMed  CAS  Google Scholar 

  • Hansen AE. Study of iodine number of serum fatty acids in infantile eczema. Proc Soc Exp Biol Med. 1933;30:1198–9.

    Google Scholar 

  • Hansen AE, Wiese HF. Essential fatty acids and human nutrition II. Serum level for unsaturated fatty acids in poorly nourished infants and children. J Nutr. 1954;52:367–74.

    PubMed  CAS  Google Scholar 

  • Hansen AE, Haggard ME, Boelesche AN, et al. Essensial fatty acids in infant nutrition III. Clinical manifestations of linoleic acid deficiency. J Nutr. 1958;66:565–76.

    PubMed  CAS  Google Scholar 

  • Hansson L, Backman A, Ny A, et al. Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis. J Invest Dermatol. 2002;118:444–9.

    Article  PubMed  CAS  Google Scholar 

  • Hara J, Higuchi K, Okamoto R, et al. High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol. 2000;115:406–13.

    Article  PubMed  CAS  Google Scholar 

  • Harding CR, Rawlings AV. Effects of natural moisturizing factor and lactic acid isomers on skin function. In: Loden M, Maibach HI, editors. Dry skin and moisturizers. 2nd ed. 2006. p. 187–200. Chapter 18.

    Google Scholar 

  • Harding CR, Watkinson A, Rawlings AV, et al. Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci. 2000;22:21–52.

    Article  PubMed  CAS  Google Scholar 

  • Harding CR, Long S, Richardson J, et al. The cornified cell envelope: an important marker of stratum corneum maturation in healthy and dry skin. Int J Cosmet Sci. 2003;25:157–67.

    Article  PubMed  CAS  Google Scholar 

  • Hartop PJ, Prottey C. Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to skin of essential fatty acid-deficient rats. Br J Dermatol. 1976;95:255–64.

    Article  PubMed  CAS  Google Scholar 

  • Higuchi K, Hara J, Okamoto R, et al. The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. Biochem J. 2000;350(Pt 3):747–56.

    Article  PubMed  CAS  Google Scholar 

  • Hirao T, Denda M, Takahashi M. Identification of immature cornified envelopes in the barrier-impaired epidermis by characterization of their hydrophobicity and antigenicities of the components. Exp Dermatol. 2001;10:35–44.

    Article  PubMed  CAS  Google Scholar 

  • Hirao T, Terui T, Takeuchi I, et al. Ratio of immature cornified envelopes does not correlate with parakeratosis in inflammatory skin disorders. Exp Dermatol. 2003;12:591–601.

    Article  PubMed  Google Scholar 

  • Horrobin DF. Essential fatty acids in clinical dermatology. J Am Acad Dermatol. 1989;20:1045–53.

    Article  PubMed  CAS  Google Scholar 

  • Horrobin DF. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr. 2000;71:367S–72.

    PubMed  CAS  Google Scholar 

  • Houtsmuller UM, van der Beek A. Effects of topical application of fatty acids. Prog Lipid Res. 1981;20:219–24.

    Article  PubMed  CAS  Google Scholar 

  • Illi S, von Mutius E, Lau S, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004;113:925–31.

    Article  PubMed  Google Scholar 

  • Imokawa G. A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. J Dermatol Sci. 2009;55:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Imokawa G, Abe A, Jin K, et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol. 1991;96:523–6.

    Article  PubMed  CAS  Google Scholar 

  • Innis SM. Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr. 2003;143:S1–8.

    PubMed  CAS  Google Scholar 

  • Ishibashi M, Arikawa J, Okamoto R, et al. Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis. Lab Invest. 2003;83:397–408.

    PubMed  CAS  Google Scholar 

  • Ishikawa J, Narita H, Kondo N, et al. Changes in the ceramide profile of atopic dermatitis patients. J Invest Dermatol. 2010;130(10):2511–4.

    Article  PubMed  CAS  Google Scholar 

  • Janssens M, van Smeden J, Gooris GS, et al. Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema. J Invest Dermatol. 2011 Jun 30. doi:10.1038/jid.2011.175.

    Article  PubMed  CAS  Google Scholar 

  • Jiang WG, Redfern A, Bryce RP, et al. Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. Prostaglandins Leukot Essent Fatty Acids. 2000;62:119–27.

    Article  PubMed  CAS  Google Scholar 

  • Johansson A, Isolauri E, Salminen S. Alpine currant seed oil as a source of polyunsaturated fatty acids in the treatment of atopic eczema. Budapest: Publishing Company of TUB; 1999.

    Google Scholar 

  • Jungersted JM, Scheer H, Mempel M, et al. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy. 2010;65:911–8.

    Article  PubMed  CAS  Google Scholar 

  • Kanehara S, Ohtani T, Uede K, et al. Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. J Dermatol. 2007a;34:811–5.

    Article  PubMed  Google Scholar 

  • Kanehara S, Ohtani T, Uede K, et al. Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children. Eur J Dermatol. 2007b;17:448–9.

    PubMed  Google Scholar 

  • Kashibuchi N, Hirai Y, O’Goshi K, et al. Three-dimensional analyses of individual corneocytes with atomic force microscope: morphological changes related to age, location and to the pathologic skin conditions. Skin Res Technol. 2002;8:203–11.

    Article  PubMed  Google Scholar 

  • Kato A, Fukai K, Oiso N, et al. Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. Br J Dermatol. 2003;148:665–9.

    Article  PubMed  CAS  Google Scholar 

  • Kezic S, Kemperman PM, Koster ES, et al. Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol. 2008;128:2117–9.

    Article  PubMed  CAS  Google Scholar 

  • Kikuchi K, Kobayashi H, O’Goshi K, et al. Impairment of skin barrier function is not inherent in atopic dermatitis patients: a prospective study conducted in newborns. Pediatr Dermatol. 2006;23:109–13.

    Article  PubMed  Google Scholar 

  • Kitz R, Rose MA, Schonborn H, et al. Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. Pediatr Allergy Immunol. 2006;17:112–7.

    Article  PubMed  Google Scholar 

  • Komatsu N, Suga Y, Saijoh K, et al. Elevated human tissue kallikrein levels in the stratum corneum and serum of peeling skin syndrome-type B patients suggests an over-desquamation of corneocytes. J Invest Dermatol. 2006;126:2338–42.

    Article  PubMed  CAS  Google Scholar 

  • Komatsu N, Saijoh K, Kuk C, et al. Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients. Exp Dermatol. 2007;16:513–9.

    Article  PubMed  CAS  Google Scholar 

  • Krahn-Bertil E, Hazane-Puch F, Lassel T, et al. Skin moisturization by dermonutrition. In: Rawlings AV, Leyden JJ, editors. Skin moisturization. 2nd ed. 2009. p. 411–25. Chapter 27.

    Chapter  Google Scholar 

  • Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol. 2000;105:860–76.

    Article  PubMed  CAS  Google Scholar 

  • Linnamaa P, Savolainen J, Koulu L, et al. Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomized, double-blind, placebo-controlled trial. Clin Exp Allergy. 2010;40:1247–55.

    Article  PubMed  CAS  Google Scholar 

  • Macheleidt O, Kaiser HW, Sandhoff K. Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol. 2002;119:166–73.

    Article  PubMed  CAS  Google Scholar 

  • Man MQ, Hatano Y, Lee SH, et al. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol. 2008;128:79–86.

    Article  PubMed  CAS  Google Scholar 

  • Manku MS, Horrobin DF, Morse N, et al. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. Prostaglandins Leukot Med. 1982;9:615–28.

    Article  PubMed  CAS  Google Scholar 

  • Marquardt A, Stohr H, White K, et al. CDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000;66:175–83.

    Article  PubMed  CAS  Google Scholar 

  • Matsumoto M, Umemoto N, Sugiura H, et al. Difference in ceramide composition between “dry” and “normal” skin in patients with atopic dermatitis. Acta Derm Venereol. 1999;79:246–7.

    Article  PubMed  CAS  Google Scholar 

  • McMahon A, Butovich IA, Mata NL, et al. Retinal pathology and skin barrier defect in mice carrying a stargardt disease-3 mutation in elongase of very long chain fatty acids-4. Mol Vis. 2007;13:258–72.

    PubMed  CAS  Google Scholar 

  • Melnik B, Hollmann J, Plewig G. Decreased stratum corneum ceramides in atopic individuals–a pathobiochemical factor in xerosis? Br J Dermatol. 1988;119:547–9.

    Article  PubMed  CAS  Google Scholar 

  • Muggli R. Systemic evening primrose oil improves the biophysical skin parameters of healthy adults. Int J Cosmet Sci. 2005;27:243–9.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr. 2004;24:345–76.

    Article  PubMed  CAS  Google Scholar 

  • Nicollier M, Massengo T, Remy-Martin JP, et al. Free fatty acids and fatty acids of triacylglycerols in normal and hyperkeratotic human stratum corneum. J Invest Dermatol. 1986;87:68–71.

    Article  PubMed  CAS  Google Scholar 

  • Nikolovski J, Stamatas GN, Kollias N, et al. Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol. 2008;128:1728–36.

    Article  PubMed  CAS  Google Scholar 

  • Okamoto R, Arikawa J, Ishibashi M, et al. Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. J Lipid Res. 2003;44:93–102.

    Article  PubMed  CAS  Google Scholar 

  • Park WJ, Kothapalli KS, Lawrence P, et al. An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3. J Lipid Res. 2009;50:1195–202.

    Article  PubMed  CAS  Google Scholar 

  • Pilgram GS, Vissers DC, van der Meulen H, et al. Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol. 2001;117:710–7.

    Article  PubMed  CAS  Google Scholar 

  • Prottey C. Investigation of functions of essential fatty acids in the skin. Br J Dermatol. 1977;97:29–38.

    Article  PubMed  CAS  Google Scholar 

  • Puch F, Samson-Villeger S, Guyonnet D, et al. Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. Exp Dermatol. 2008;17:668–74.

    Article  PubMed  CAS  Google Scholar 

  • Rawlings AV. Trends in stratum corneum research and the management of dry skin conditions. Int J Cosmet Sci. 2003;25:63–95.

    Article  PubMed  CAS  Google Scholar 

  • Rawlings AV. Recent advances in skin ‘barrier’ research. J Pharm Pharmacol. 2010;62:671–7.

    PubMed  CAS  Google Scholar 

  • Rawlings AV, Krahn-Bertil F, et al. Skin moisturisation by dermonutrition: outcomes of a dairy matrix product. 2011;32–43.

    Google Scholar 

  • Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol. 2005;124:1099–110.

    Article  PubMed  CAS  Google Scholar 

  • Rawlings AV, Scott IR, Harding CR, et al. Stratum corneum moisturization at the molecular level. J Invest Dermatol. 1994;103:731–41.

    Article  PubMed  CAS  Google Scholar 

  • Redoules D, Tarroux R, Assalit MF, et al. Characterisation and assay of five enzymatic activities in the stratum corneum using tape-strippings. Skin Pharmacol Appl Skin Physiol. 1999;12:182–92.

    PubMed  CAS  Google Scholar 

  • Rogers J, Harding C, Mayo A, et al. Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res. 1996;288:765–70.

    Article  PubMed  CAS  Google Scholar 

  • Saaf AM, Tengvall-Linder M, Chang HY, et al. Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes. PLoS One. 2008;3:e4017.

    Article  PubMed  CAS  Google Scholar 

  • Schaeffer L, Gohlke H, Muller M, et al. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet. 2006;15:1745–56.

    Article  PubMed  CAS  Google Scholar 

  • Schafer L, Kragballe K. Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis. J Invest Dermatol. 1991;96:10–5.

    Article  PubMed  CAS  Google Scholar 

  • Scharschmidt TC, Man MQ, Hatano Y, et al. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol. 2009;124(496–506):e1–6.

    PubMed  Google Scholar 

  • Senapati S, Banerjee S, Gangopadhyay DN. Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. Indian J Dermatol Venereol Leprol. 2008;74:447–52.

    Article  PubMed  Google Scholar 

  • Sprecher H, Luthria DL, Mohammed BS, et al. Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J Lipid Res. 1995;36:2471–7.

    PubMed  CAS  Google Scholar 

  • Tagami H, Kobayashi H, O’Goshi K, et al. Atopic xerosis: employment of noninvasive biophysical instrumentation for the functional analyses of the mildly abnormal stratum corneum and for the efficacy assessment of skin care products. J Cosmet Dermatol. 2006;5:140–9.

    Article  PubMed  Google Scholar 

  • Taieb A. Hypothesis: from epidermal barrier dysfunction to atopic disorders. Contact Dermatitis. 1999;41:177–80.

    Article  PubMed  CAS  Google Scholar 

  • Tarroux R, Assalit MF, Licu D, et al. Variability of enzyme markers during clinical regression of atopic dermatitis. Skin Pharmacol Appl Skin Physiol. 2002;15:55–62.

    PubMed  CAS  Google Scholar 

  • Tokura Y. Extrinsic and intrinsic types of atopic dermatitis. J Dermatol Sci. 2010;58:1–7.

    Article  PubMed  CAS  Google Scholar 

  • Tsang M, Guy RH. Effect of aqueous cream BP on human stratum corneum in vivo. Br J Dermatol. 2010;163(5):954–8. doi:10.1111/j.1365-2133.2010.09954.x.

    Article  PubMed  CAS  Google Scholar 

  • Uchida Y, Holleran WM. Omega-O-acylceramide, a lipid essential for mammalian survival. J Dermatol Sci. 2008;51:77–87.

    Article  PubMed  CAS  Google Scholar 

  • van Gool CJ, Thijs C, Henquet CJ, et al. Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis–a randomized controlled trial in infants at high familial risk. Am J Clin Nutr. 2003;77:943–51.

    PubMed  Google Scholar 

  • van Gool CJ, Zeegers MP, Thijs C. Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. Br J Dermatol. 2004;150:728–40.

    Article  PubMed  CAS  Google Scholar 

  • Vasilopoulos Y, Cork MJ, Murphy R, et al. Genetic association between an AACC insertion in the 3′UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. J Invest Dermatol. 2004;123:62–6.

    Article  PubMed  CAS  Google Scholar 

  • Vasireddy V, Uchida Y, Salem Jr N, et al. Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Hum Mol Genet. 2007;16:471–82.

    Article  PubMed  CAS  Google Scholar 

  • Voegeli R, Doppler S, Joller P, et al. Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin. Int J Cosmet Sci. 2011 Jun 24. doi: 10.1111/j.1468-2494.2011.00671.x.

    Article  PubMed  CAS  Google Scholar 

  • Voegeli R, Rawlings AV, Breternitz M, et al. Increased stratum corneum serine protease activity in acute eczematous atopic skin. Br J Dermatol. 2009;161:70–7.

    Article  PubMed  CAS  Google Scholar 

  • Wertz PW, Downing DT. Metabolism of linoleic acid in porcine epidermis. J Lipid Res. 1990;31:1839–44.

    PubMed  CAS  Google Scholar 

  • White MI, Jenkinson DM, Lloyd DH. The effect of washing on the thickness of the stratum corneum in normal and atopic individuals. Br J Dermatol. 1987;116:525–30.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto A, Serizawa S, Ito M, et al. Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res. 1991;283:219–23.

    Article  PubMed  CAS  Google Scholar 

  • Ziboh VA. Essential fatty acids/eicosanoid biosynthesis in the skin: biological significance. Proc Soc Exp Biol Med. 1994;205:1–11.

    PubMed  CAS  Google Scholar 

  • Ziboh VA, Chapkin RS. Biologic significance of polyunsaturated fatty acids in the skin. Arch Dermatol. 1987;123:1686a–90.

    Article  PubMed  CAS  Google Scholar 

  • Ziboh VA, Miller CC. Essential fatty acids and polyunsaturated fatty acids: significance in cutaneous biology. Annu Rev Nutr. 1990;10:433–50.

    Article  PubMed  CAS  Google Scholar 

  • Ziboh VA, Cho Y, Mani I, et al. Biological significance of essential fatty acids/prostanoids/lipoxygenase-derived monohydroxy fatty acids in the skin. Arch Pharm Res. 2002;25:747–58.

    Article  PubMed  CAS  Google Scholar 

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Rawlings, A.V. (2011). Essential Fatty Acids and Atopic Dermatitis. In: Pappas, A. (eds) Nutrition and Skin. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7967-4_11

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  • DOI: https://doi.org/10.1007/978-1-4419-7967-4_11

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