Skip to main content
SpringerLink
Log in

Genetics of Myocardial Infarction

  • Chapter
  • First Online:
Genes and Cardiovascular Function

  • 601 Accesses

Abstract

Numerous teams are trying to find a genetic determination of individuals with high risk of myocardial infarction. Originally more attention was paid to candidate genes of atherosclerosis risk factors – hypercholesterolemia and hypertension. Out of several hundreds of potential genes involved, only effect of polymorphism of apolipoprotein E was reproduced in different settings and populations. Attention was focused to genes involved in monocyte behavior, arterial wall metabolism, and thromboembolic process more recently. Still the significant effect of few genes is low (OR 1.2–1.7), and in addition reproducibility is very low. Genome-wide scan has been used recently and most discriminative part was identified in chromosome 9 (but without any known protein function). Low reproducibility in different projects is probably related to low number of cases and controls. On the other hand, project with several thousands of individuals in compared groups suffered from inadequate characteristics of individuals, and gene environment interaction might also have substantial effect in reproducibility. Participation of high number of candidate genes with very small or negligible effect is supposed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Austin MA, Thalmud PJ, Luong LA, et al. Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins. Am J Hum Genet. 1998;62:406–19.

    Article  PubMed  CAS  Google Scholar 

  2. Marenberg ME, Risch N, Berkman LF, et al. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med. 1994;330:1041–6.

    Article  PubMed  CAS  Google Scholar 

  3. Kathiresan S, melander O, Anevski D, et al. Polymor­phisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240–9.

    Article  PubMed  CAS  Google Scholar 

  4. Frikke-Schmidt R, Nordestgaard BG, Jensen GB, et al. Genetic variation in ABCA1 predicts ischemic heart disease in the general population. Arterioscler Thromb Vasc Biol. 2008;28:180–6.

    Article  PubMed  CAS  Google Scholar 

  5. Elder SJ, Lichtenstein AH, Pittas AG, et al. Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome. J Lipid Res. 2009;50:1917–26.

    Article  PubMed  CAS  Google Scholar 

  6. Després J-P, Lemieux I, Bergeron J, et al. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 2008;28:1039–49.

    Article  PubMed  Google Scholar 

  7. Arsenault BJ, Lemieux I, Despres J-P, et al. The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk Prospective Population Study. CMAJ. 2010;182:1427–32.

    Article  PubMed  Google Scholar 

  8. Talmud PJ, Smart M, Presswood E, et al. ANGPTL4 E40K and T266M effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk. Arterioscler Thromb Vasc Biol. 2008;28:2319–25.

    Article  PubMed  CAS  Google Scholar 

  9. Zimmermann E, Kring SI, Berentzen TL, et al. Fatness-associated FTO gene variant increases mortality independent of fatness – in cohorts of Danish men. PLoS ONE. 2009;4:e4428.

    Article  PubMed  Google Scholar 

  10. Poledne R, Lorenzova A, Staveke P, et al. Proinflammatory status, genetics and atherosclerosis. Physiol Res. 2009;25:S111–18.

    Google Scholar 

  11. Licastro F, Chiapellim M, Caldarera CM, et al. Acute myocardial infarction and proinflammatory gene variants. Ann N Y Acad Sci. 2007;1119:227–42.

    Article  PubMed  CAS  Google Scholar 

  12. Thompson SR, Macaskie PA, Beiby JP, et al. IL 188 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease. Clin Chem. 2007;53:2078–85.

    Article  PubMed  CAS  Google Scholar 

  13. Hubacek JA, Stamek V, Gebauerova M, et al. A FTO variant and risk of acute coronary syndrome. Clin Chim Acta. 2010;100:1069–72.

    Article  Google Scholar 

  14. Visvikis-Siest S, Marteau JB. Genetic variants predisposing to cardiovascular disease. Curr Opin Lipidol. 2006;17:139–51.

    Article  PubMed  CAS  Google Scholar 

  15. Humphries SE, Cooper JA, Thalmud PJ, et al. Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. Clin Chem. 2007;53:8–16.

    Article  PubMed  CAS  Google Scholar 

  16. Armendariz AD, Krauss RM. Hepatic nuclear factor 1-α:inflammation, genetics and atherosclerosis. Curr Opin Lipidol. 2009;20:106–11.

    Article  PubMed  CAS  Google Scholar 

  17. Poledne R, Hubacek JA, Stanek V, et al. Why we are not able to find the coronary heart disease gene – apoE as an example. Folia Biol (Praha). 2010;56:218–22.

    CAS  Google Scholar 

  18. Shiffman D, Kane JP, Louie JZ, et al. Analysis of 17,576 potentially functional SNP´s in three case-control studies of myocardial infarction. PLoS ONE. 2008;3:e2895.

    Article  PubMed  Google Scholar 

  19. Coronary Artery Disease Consortium. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol. 2009;29:774–80.

    Article  Google Scholar 

  20. McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488–91.

    Article  PubMed  CAS  Google Scholar 

  21. Humphries SE, Yinnakouris N, Talmud PJ, et al. Cardiovascular disease risk prediction using genetic information (gene scores): is it really informative? Curr Opin Lipidol. 2008;16:128–32.

    Article  Google Scholar 

  22. Samani NJ, Erdmann J, Hall AS, et al. Genome-wide association analysis of coronary artery disease. N Engl J Med. 2007;357:443–53.

    Article  PubMed  CAS  Google Scholar 

  23. Helgadottir A, Thorleifsson G, Manolescu A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316:1491–3.

    Article  PubMed  CAS  Google Scholar 

  24. Ordovas JM, Tai ES. Why study gene-environment interactions? Curr Opin Lipidol. 2008;19:158–67.

    Article  PubMed  CAS  Google Scholar 

  25. Talmud PJ. Gene-environment interaction and its impact on coronary heart disease risk. Nutr Metab Cardiovasc Dis. 2007;17:148–52.

    Article  PubMed  CAS  Google Scholar 

  26. Stephens JW, Bain SC, Humphries SE, et al. Gene-environment interaction and oxidative stress in cardiovascular disease. Atherosclerosis. 2008;200:229–38.

    Article  PubMed  CAS  Google Scholar 

  27. Hubacek JA, Stanek V, Gebauerova M, et al. Lack of an association between connexin-37, stromelysin-1, plasminogen activator-inhibitor type 1 and lymphotoxin-alpha genes and acute coronary syndrome in Czech Caucasians. Exp Clin Cardiol. 2010;15:e52–6.

    PubMed  CAS  Google Scholar 

  28. Liu S, Ma J, Ridker PM, et al. A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy men. Atherosclerosis. 2003;166:323–9.

    Article  PubMed  CAS  Google Scholar 

  29. Schmitz F, Mevissen V, Krantz C, et al. Robust association of the APOE ε4 allele with premature myocardial infarction especially in patients without hypercholesterolaemia: the Aachen study. Eur J Clin Invest. 2007;37:106–8.

    Article  PubMed  CAS  Google Scholar 

  30. Parnell LD, Lee YC, Lai CQ, et al. Adaptive genetic variation and heart disease risk. Curr Opin Lipidol. 2010;21:116–22.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Clinical and Experimental Medicine and Centre for Cardiovascular Research, Prague, Czech Republic

    Rudolf Poledne & Jaroslav A. Hubacek

Authors
  1. Rudolf Poledne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jaroslav A. Hubacek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rudolf Poledne .

Editor information

Editors and Affiliations

  1. Czech Republic, Institute of Physiology, Academy of Sciences of the, Videnska 1083, Prague, 142 20, Czech Republic

    Bohuslav Ostadal

  2. Jikei University School of Medicine, Shibuya-ku, Ebisu 3-31-6, Tokyo, 150-0013, Japan

    Makoto Nagano

  3. St. Boniface General Hospital, Research Centre, Institute of Cardiovascular Sciences, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Poledne, R., Hubacek, J.A. (2011). Genetics of Myocardial Infarction. In: Ostadal, B., Nagano, M., Dhalla, N. (eds) Genes and Cardiovascular Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7207-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-7207-1_11

  • Published:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-7206-4

  • Online ISBN: 978-1-4419-7207-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation