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Reprogramming of Somatic Cells to Pluripotency

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The Cell Biology of Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 695))

Abstract

Reprogramming of somatic cells into pluripotent stem cells has been achieved by introducing four transcription factors, Sox2, Oct3/4, Klf4 and c-Myc, in 2006. These induced pluripotent stem (iPS) cells have raised hopes for a new era of regenerative medicine because they can avoid the ethical problems and innate immune rejection associated with embryonic stem cells. However, the underlying molecular mechanism of reprogramming still remains unclear. In this chapter, we look back at the history of reprogramming research ranging from amphibian to mammalian cells and discuss our recent understanding of the molecular mechanisms of reprogramming and the possibility of utilizing reprogrammed cells for regenerative medicine.

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Author information

Authors and Affiliations

  1. Center for iPS Research and Application Institute for Integrated Cell-Material Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Masato Nakagawa & Shinya Yamanaka

Authors
  1. Masato Nakagawa
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  2. Shinya Yamanaka
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Correspondence to Masato Nakagawa .

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Editors and Affiliations

  1. Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

    Eran Meshorer PhD

  2. Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California, USA

    Kathrin Plath PhD

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Nakagawa, M., Yamanaka, S. (2010). Reprogramming of Somatic Cells to Pluripotency. In: Meshorer, E., Plath, K. (eds) The Cell Biology of Stem Cells. Advances in Experimental Medicine and Biology, vol 695. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7037-4_14

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