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Abortive Apoptosis and Sperm Chromatin Damage

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Sperm Chromatin

Abstract

The term apoptosis refers to a morphologically distinct form of cell death that plays a major role during the normal development and homeostasis of multicellular organisms. This mode of cell death is a tightly regulated series of energy-dependent molecular and biochemical events orchestrated by a genetic program. Apoptosis is either developmentally regulated (launched in response to specific stimuli, such as deprivation of survival factors, exposure to ionizing radiation and chemotherapeutic drugs, or activation by various death factors and their ligands) or induced in response to cell injury or stress. Apoptosis is also being recognized in the pathogenesis of many diverse human diseases including cancer, acquired immune deficiency syndrome, neurodegenerative disorders, atherosclerosis, and cardiomyopathy. Maintaining the homeostatic relationship between apoptosis and cell proliferation is important for tissue development and degeneration. Decreased apoptosis may lead to neoplasia, whereas increased apoptosis may lead to a dystrophic condition.

The online version of the original chapter can be found at http://dx.doi.org/10.1007/978-1-4419-6857-9_20

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-1-4419-6857-9_38

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Authors and Affiliations

  1. Department of Dermatology, STD’s and Andrology, Al-Minya University, 61519, Al-Minya, Egypt

    Hasan M. El-Fakahany MD

  2. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

    Denny Sakkas PhD

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  1. Hasan M. El-Fakahany MD
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  2. Denny Sakkas PhD
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Correspondence to Hasan M. El-Fakahany MD .

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Editors and Affiliations

  1. St. Mary's Hospital, Div. Urology, McGill University, Lacombe Avenue 3830, Montreal, H3T 1M5, Québec, Canada

    Armand Zini

  2. Lerner College of Medicine, Center for Reproductive Medicine, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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El-Fakahany, H.M., Sakkas, D. (2011). Abortive Apoptosis and Sperm Chromatin Damage. In: Zini, A., Agarwal, A. (eds) Sperm Chromatin. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6857-9_20

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  • DOI: https://doi.org/10.1007/978-1-4419-6857-9_20

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