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An Ethos of Genetic Testing

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Inherited Cancer Syndromes

Abstract

It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity, it was the season of light, it was the season of darkness, it was the spring of hope, it was the winter of despair, we had everything before us, we had nothing before us, we were all going direct to Heaven, we were all going direct the other way-in short, the period was so far like the present period, that some of its noisiest authorities insisted on its being received, for good or for evil, in the superlative degree of comparison only.

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References

  1. Dickens CJH. A tale of two cities (1859). New York: Everyman’s Library, P. Dutton, Publishers, 1948.

    Google Scholar 

  2. Starr P. The social transformation of American medicine. New York: Basic Books, Inc., 1982.

    Google Scholar 

  3. Pellegrino ED. Humanism and the physician. Knoxville, Tennessee: University of Tennessee Press, 1979.

    Google Scholar 

  4. Pellegrino ED, Thomasma DC. The virtues in medical practice. New York: Oxford University Press, 1993.

    Google Scholar 

  5. Orr RD, Chay A. Medical ethics. A primer for students. Bristol, Tennessee: Paul Tournier Institute, Christian Medical and Dental Association, 2000.

    Google Scholar 

  6. Plato. Res Publica (The Republic, 360 B.C.E.). Translator, Jowett B. In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; 295–441.

    Google Scholar 

  7. Aristotle. Ethica Nicomachea (Nicomachean Ethics, 350 B.C.E.). Translator, Ross WD. In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; 339–444.

    Google Scholar 

  8. Epictetus. Diatribai (Discourses, circa C.E. 138). Translator, Long G. In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; 105–252.

    Google Scholar 

  9. Cicero MT. De Re Publica (The Republic, 51 B.C.E.). Translator and Editor, Zetzel JEG. Cambridge, England: Cambridge Publishing Company, Ltd, 1995.

    Google Scholar 

  10. Seneca LA. Epistulae Morales ad Lucilium (Epistles Regarding Morals to Lucilium, C.E. 65). Latina Romono Bibliotheca, Latina Intra Text, 2006. http://info@intratext.com//.

    Google Scholar 

  11. Marcus Aurelius AA. Ta eis heauton (Meditations, C.E. 170–180). Translator, Long G. Cambridge, Massachusetts: Harvard Classics, 1862.

    Google Scholar 

  12. Augustine S. De Civitate Dei (The City of God, C.E. 426). Translator, Dods M. New York: Modem Library Paperback Classics, Random House Publishers, 2000.

    Google Scholar 

  13. Aquinas S.T. Summa Theologica (Systematic Theology, 1265–1274). Translators and Publishers, Fathers of the English Dominican Province, 1920.

    Google Scholar 

  14. Lucretius. De Rerum Natura (On the Nature of Things, 94 B.C.E.). Translator, Latham RE. Revised Edition, New York: Penguin Classics, 1994.

    Google Scholar 

  15. Locke J. An Essay Concerning Human Understanding (1690). Collator and Annotator, Froyer AC. In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; 85–402.

    Google Scholar 

  16. Kant L. Kritik der Reinen Vernuft (Critique of Pure Reason, 1781). Translators and Editors, Guyer P, Wood AW. Cambridge, England: Cambridge University Press, 1998.

    Google Scholar 

  17. Kant L. Kritik, der Praktischen Vernuft (Critique of Practical Reason, 1788). Translator, Abbott JK. Cambridge, England: Cambridge University Press, 1998.

    Google Scholar 

  18. Kant L. Grundlegung zur Metaphysik der Sitten (Groundwork of Metaphysics and Morals, 1785). Translator, Abbott JK. Orchard Park, New York: Broadview Press, 2005.

    Google Scholar 

  19. Hobbes T. Leviathan, Or, Matter, Forme and Power of a Commonwealth Ecclesiastical and Civil (1651). In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; 39–283.

    Google Scholar 

  20. Machiavelli N. The Prince (1513). Translator, Marriott WK. In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; 1–37.

    Google Scholar 

  21. Bentham J. Deontology; or, The Science of Morality (Bowring J, Editor). London: Longman Publishers, Ltd., 1834.

    Google Scholar 

  22. Mill JS. Utilitarianism (1863). In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; 445–76.

    Google Scholar 

  23. Weber M. Politik als Beruf (Essays in Sociology, 1919). Translators, Gerth HH and Mills CW. Oxford, England: Oxford University Press, 1946.

    Google Scholar 

  24. Dewey J. The study of ethics: a syllabus. Ann Arbor, Michigan: Register Publishing Co., 1894.

    Google Scholar 

  25. Ross WO. The right and the good. Oxford, England: Clarendon Press, 1930.

    Google Scholar 

  26. Editorial Board. The Nuremberg code. J Am Med Assoc. 1996;276:1691.

    Article  Google Scholar 

  27. Editorial Board. World Medical Association. Declaration of Helsinki. J Am Med Assoc. 1997;277:925–6.

    Article  Google Scholar 

  28. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report. Washington, DC: U.S. Government Printing Office, 1979.

    Google Scholar 

  29. Council for International Organizations of Medical Sciences (C.I.O.M.S.). International ethical guidelines for biomedical research involving human subjects. Geneva, Switzerland: C.I.O.M.S, 1993.

    Google Scholar 

  30. Levine RJ. Ethics and regulations of clinical research. Second Edition, New Haven, Connecticut: Yale University Press, 1988.

    Google Scholar 

  31. Emanuel EJ, Wendler D, Grady C. What makes clinical research ethical? J Am Med Assoc. 2000;283:2701–11.

    Article  CAS  Google Scholar 

  32. William of Ockham. Exposito Aurea et Admodum Utilis Super Artem Veterem Aristotelis, (1323). Bologna, Italy: Benedictus Hectoris, 1496.

    Google Scholar 

  33. Taylor HJ. The story of the 4-way test. Rotary International, 1954–1955.

    Google Scholar 

  34. President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Screening and Counseling for Genetic Conditions: A Report on the Ethical, Social, and Legal Implications of Genetic Screening, Counseling, and Education Programs. Washington, DC: U.S. Government Printing Office, 1983.

    Google Scholar 

  35. Hippocrates. Oath. Hippocratic Writings (400 B.C.E.). Translator, Adams F. In: Great Books of the Western World (Hutchins RM, Editor-in-Chief). Chicago: Encyclopaedia Britannica, Inc., 1952; xiii.

    Google Scholar 

  36. Wertz DC, Fletcher JC, Berg K. Review of Ethical Issues in Medical Genetics, Report of Consultants to WHO. Human Genetics Programme. Management of Noncommunicable Diseases. Geneva, Switzerland: World Health Organization, 2003.

    Google Scholar 

  37. American Society of Human Genetics Board of Directors, American College of Medical Genetics Board of Directors. Points to consider: ethical, legal and psychosocial implications of genetic testing in children and adolescents. Am J Hum Genet. 1995;57:1233–41.

    Google Scholar 

  38. Wertz DC, Fanos JH, Reilly PR. Genetic testing for children and adolescents: who decides? J Am Med Assoc. 1994;272(11):875–81.

    Article  CAS  Google Scholar 

  39. Duncan RE, Belmett F, Martin BD. Refusing to provide a prenatal test: can it ever be ethical? Br Med J. 2006;333:1066–8.

    Article  Google Scholar 

  40. Clinical Genetics Society. The genetic testing of children. Working Party of the Clinical Genetics Society (UK). J Med Genet. 1994;31:785–97.

    Article  Google Scholar 

  41. Human Genetics Society of Australia. Predictive testing in children and adolescents (version 2, April 2005). http://www.hgsa.com.au//.

  42. Offit K, Kohut K, Clagett B, et al. Cancer genetic testing and assisted reproduction. J Clin Reprod. 2006;24(29):4775–82.

    Google Scholar 

  43. Ethics Committee Report, American Society for Reproductive Medicine. Fertility preservation and reproduction in cancer patients. Fertil Steril. 2005;83(6):1622–8.

    Article  Google Scholar 

  44. Verlinsky Y, Cohen J, Santiago M, et al. Over a decade of experience with preimplantation genetic diagnosis: a multicenter report. Fertil Steril. 2004;82(2):292–4.

    Article  PubMed  Google Scholar 

  45. Williams C, Ehrich K, Farsides B, et al. Facilitating choice, framing choice: staff views on widening the scope of preimplantation genetics diagnosis in the UK. Soc Sci Med. 2007;65(6):1094–1105[au8].

    Google Scholar 

  46. Oftit K, Sagi M, Hurley K. Preimplantation genetic diagnosis for cancer syndromes: a new challenge for preventive medicine. J Am Med Assoc. 2006;296(22):2727–2730.

    Article  Google Scholar 

  47. Verlinsky Y, Rechitsky S, Schoolcraft W, et al. Preimplantation diagnosis for Fanconi anemia combined with HLA matching. J Am Med Assoc. 2001;285:3130–3.

    Article  CAS  Google Scholar 

  48. Kevles DJ. In the name of eugenics: genetics and the uses of human heredity. Cambridge, Massachusetts: Harvard University Press, 1985; 1995.

    Google Scholar 

  49. Stein AM. Eugenic nation: faults and frontiers of better breeding in modern America. Berkeley, California: University of California Press, 2005.

    Google Scholar 

  50. Lombardo PA. Three Generations, No Imbeciles: Virginia Eugenics and Buck v. Bell. Sixth Annual Kenneth R. Crispell Memorial History Lecture, Health Sciences Library, University of Virginia, Charlottesville, Virginia, April 23, 2002. http://www.healthsystem.virginia.edu//.

  51. Shute N. Unraveling your DNA’s secrets. US News & World Report. January 8, 2007; 51–58.

    Google Scholar 

  52. The Hastings Center, College of Physicians and Surgeons/Columbia University. Genetic Dilemmas in Primary Care. http://www.geneticdilemmas.org//.

  53. Pope A. Essay on man (1733–1734). In: Selected Works of Alexander Pope. New York: Modern Library, Random House Publishers, 1948.

    Google Scholar 

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Acknowledgements

The authors gratefully acknowledge and commend the chapter written by T. F. Ackerman entitled “Ethical Issues in Genetic Testing for Cancer Susceptibility” in the First Edition of this monograph. We also express appreciation to Ms. Betty J. Young-Pledger, Secretary V, and Ms. Patricia A. Dickinson, Word Processing Specialist, Department of Surgery, College of Medicine and Medical Center University of South Alabama, Mobile, Alabama, for superbly typing our manuscript.

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Correspondence to Roy E. Gandy .

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Gandy, R.E., Rodning, C.B. (2011). An Ethos of Genetic Testing. In: Ellis, C. (eds) Inherited Cancer Syndromes. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6821-0_3

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  • DOI: https://doi.org/10.1007/978-1-4419-6821-0_3

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