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Neuroendocrine Regulation

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Epidemiology of Obesity in Children and Adolescents

Part of the book series: Springer Series on Epidemiology and Public Health ((SSEH,volume 2))

Abstract

Obesity is a major problem in developed countries and the development of an effective treatment is an important area of research. In order to reach this goal, we must first know how metabolism and appetite are controlled, both in the periphery, as well as in the central nervous system. Due to the increased interest in this area of research, our understanding of the neuroendocrine control of food intake and energy expenditure has increased dramatically in recent years. New neuropeptides have been identified and new metabolic roles of previously known neuropeptides and neurotransmissors have been demonstrated. This chapter will briefly describe the various brain areas involved in metabolic control, concentrating on the hypothalamus and the specific nuclei of this brain area most intimately involved in the control of appetite and metabolism. Special attention will be paid to the hypothalamic neuronal populations that produce neuropeptide Y (NPY)/agouti-related protein (AgRP) and proopiomelanortin (POMC)/cocaine- and amphetamine-regulated transcript (CART). These two neuronal populations are central to metabolic and have been the subject of much investigation.

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Authors and Affiliations

  1. Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

    Vicente Barrios, Gabriel Ángel Martos-Moreno, Julie A. Chowen & Jesús Argente

  2. CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto Carlos III, Madrid, Spain

    Laura M. Frago & Jesús Argente

  3. Department of Pediatrics, Hospital Infantil Universitario Niño Jesús, Avda. Menéndez Pelayo, 65, E-28009, Madrid, Spain

    Vicente Barrios, Gabriel Ángel Martos-Moreno, Laura M. Frago, Julie A. Chowen & Jesús Argente

  4. Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain

    Jesús Argente

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  1. Vicente Barrios
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  2. Gabriel Ángel Martos-Moreno
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  3. Laura M. Frago
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  4. Julie A. Chowen
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  5. Jesús Argente
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Correspondence to Jesús Argente .

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  1. Fac. Ciencias, Inst. Ciencia de Materiales de Aragon, Universidad de Zaragoza, Zaragoza, 50009, Spain

    Luis A. Moreno

  2. FB Mathematik und Informatik, Inst. Statistik, Univ. Bremen, Bibliothekstr. 1, Bremen, 28359, Germany

    Iris Pigeot

  3. und Sozialmedizin (BIPS), Bremer Institut für Präventionsforschung, Linzer Str. 8-10, Bremen, 28359, Germany

    Wolfgang Ahrens

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Barrios, V., Martos-Moreno, G.Á., Frago, L.M., Chowen, J.A., Argente, J. (2011). Neuroendocrine Regulation. In: Moreno, L., Pigeot, I., Ahrens, W. (eds) Epidemiology of Obesity in Children and Adolescents. Springer Series on Epidemiology and Public Health, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6039-9_16

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