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Biological Horizons for Targeting Brain Malignancy

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Frontiers in Brain Repair

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 671))

Abstract

Though currently available clinical treatments and therapies have clearly extended the survival of patients with brain tumors, many of these advances are short lived, particularly with respect to high grade gliomas such as glioblastoma multiforme. The missing link to an efficacious treatment of high grade gliomas is a more complete understanding of the basic molecular and cellular origin of brain tumors. However, new discoveries of stem cell and developmental neurobiology have now borne the cancer stem cell hypothesis, drawing off of intriguing similarities between benign and malignant cells within the central nervous system. Investigation of cancer stem cell hypothesis and brain tumor propagation is the current frontier of stem cell and cancer biology. Neurosurgery is also watching closely this promising new area of focus. “Molecular neurosurgery”, glioma treatments involving biologics using neural stem cells to target the cancer at the level of individual migratory cell, is a rapidly evolving field. This coming progression of applied cancer stem cell research, coupled with current modalities, promises more comprehensive brain cancer interventions.

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Authors and Affiliations

  1. Department of Neurological Surgery, Oregon Health and Sciences University, Portland, Oregon, USA

    Samuel A. Hughes

  2. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Pragathi Achanta

  3. Harvard Medical School, Boston, Massachusetts, USA

    Allen L. Ho

  4. Del E. Webb Neuroscience, Aging and Stem Cell Research Center, Burnham Institute for Regenerative Medicine, La Jolla, California, USA

    Vincent J. Duenas

  5. Department of Neurosurgery, Neuroscience and Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, Maryland, USA

    Alfredo Quiñones-Hinojosa

Authors
  1. Samuel A. Hughes
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  2. Pragathi Achanta
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  3. Allen L. Ho
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  4. Vincent J. Duenas
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  5. Alfredo Quiñones-Hinojosa
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Corresponding author

Correspondence to Alfredo Quiñones-Hinojosa .

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Editors and Affiliations

  1. Division of Neurosurgery, City of Hope Comprehensive Cancer Center & Beckman Research Institute, Duarte, California, USA

    Rahul Jandial MD, PhD

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Hughes, S.A., Achanta, P., Ho, A.L., Duenas, V.J., Quiñones-Hinojosa, A. (2010). Biological Horizons for Targeting Brain Malignancy. In: Jandial, R. (eds) Frontiers in Brain Repair. Advances in Experimental Medicine and Biology, vol 671. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5819-8_8

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