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Mechanisms by Which Catecholamines Induce Growth in Gram-Negative and Gram-Positive Human Pathogens

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Microbial Endocrinology

Abstract

Iron is essential for the growth of most bacteria, and its availability can determine the outcome of an infection. Pathogenic bacteria have evolved a variety of mechanisms to acquire this essential nutrient from host iron sequestering proteins such as transferrin and lactoferrin. Recently, this array of bacterial iron scavenging mechanisms has also been shown to include opportunistic use of catecholamine stress hormones and inotropes to directly acquire iron from transferrin and lactoferrin. Other mechanisms include catecholamine induction of novel bacterial growth inducers. This chapter considers in detail the several mechanisms by which catecholamines can stimulate the growth of infectious bacteria.

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Authors and Affiliations

  1. Department of Infection, Immunity and Inflammation, School of Medicine, University of Leicester, University Road, Leicester, LE1 9HN, UK

    Primrose P. E. Freestone & Sara Sandrini

Authors
  1. Primrose P. E. Freestone
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  2. Sara Sandrini
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Correspondence to Primrose P. E. Freestone .

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Editors and Affiliations

  1. Health Sciences Center, School of Pharmacy, Texas Tech University, 4th Street 3601, Lubbock, 79430, USA

    Mark Lyte

  2. School of Medicine, Dept. Infection, Immunity & Inflammation, University of Leicester, Leicester, United Kingdom

    Primrose P.E. Freestone

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Freestone, P.P.E., Sandrini, S. (2010). Mechanisms by Which Catecholamines Induce Growth in Gram-Negative and Gram-Positive Human Pathogens. In: Lyte, M., Freestone, P. (eds) Microbial Endocrinology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5576-0_3

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